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Drug eluting balloon versus drug eluting stent in percutaneous coronary interventions: insights from a meta-analysis of 1462 patients.

Abstract：

BACKGROUND:Drug eluting balloons (DEB) have been developed to overcome the limitations of drug eluting stents (DES), but clinic results of various DEB studies are still not consistent. Thus, we performed a meta-analysis to compare outcomes of DEB and DES for the treatment of coronary artery disease (CAD). METHODS:Medline/Web databases were searched for studies comparing DEB and DES for obstructive CAD, reporting late lumen loss (LLL) and rates for overall mortality, myocardial infarction (MI), stent thrombosis (ST) and target lesion revascularization (TLR). RESULTS:8 studies (1462 patients) were included in the meta-analysis. Compared with DES, DEB treated patients showed non-significantly higher LLL (weighted mean difference [WMD] 0.32, 95% confidence interval [CI] -0.15 to 0.78, P=0.18) and non-significantly higher rate of binary restenosis (odds ratio [OR] 1.40 [0.68-2.48], P=0.36). Mortality (OR 1.13[0.54-2.37], P=0.74), MI (OR 0.95, [0.50-1.80], P=0.87), ST (OR 1.12, [0.34-4.19], P=0.77) and TLR rates (OR 1.19[0.60-2.38], P=0.61) were similar between the 2 treatments. A pre-specified meta-regression analysis showed that LLL WMD and TLR OR were inversely correlated to the prevalence of diabetes (P<0.0001) and directly correlated to reference coronary diameters (P<0.001). CONCLUSIONS:The present meta-analysis showed that compared to DES, DEB use resulted in similar clinical efficacy and safety. Thus DEB could be considered a reasonable alternative to DES for the treatment of CAD in selected clinical settings (Clinicaltrials.gov identifier: NCT01760200).

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Lupi A,Rognoni A,Secco GG,Porto I,Nardi F,Lazzero M,Rossi L,Parisi R,Fattori R,Genoni G,Rosso R,Stella PR,Sheiban I,Bolognese L,Liistro F,Bongo AS,Agostoni P

doi

10.1016/j.ijcard.2013.07.161

subject

Has Abstract

pub_date

2013-10-12 00:00:00

pages

4608-16

issue

5

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(13)01386-7

journal_volume

168

pub_type

杂志文章,meta分析

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