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Reference values for left and right ventricular trabeculation and non-compacted myocardium.

Abstract：

BACKGROUND:Since the differentiation between physiological and pathological trabeculation is challenging, we assessed its distribution in a reference population of selected healthy volunteers. METHODS:We studied 117 subjects (58 males) stratified into age tertiles and by gender. Cardiovascular magnetic resonance images were acquired using a standard SSFP-sequence. Left and right ventricular (LV/RV) end-diastolic (EDV), end-systolic (ESV) and trabeculated volumes indexed to the body surface area as well as ejection fraction (EF) were quantified in short-axis views. The maximum non-compacted-to-compacted (NC/C) ratio was measured in long-axis views. RESULTS:The trabeculated volumes were significantly larger in men than in women and decreased with age. The correlation between both was moderate (r=0.46; p<0.001). LV trabeculated volume was positively associated with EDV and ESV (r=0.74; r=0.59; both p<0.001) and negatively with EF (r=-0.27; p<0.005). It was no independent predictor for EF. The maximum NC/C ratio was >2.3 in 46.2% and >2.5 in 37.6% of the subjects, which is regarded as abnormal in current literature. The fraction of subjects with a maximum NC/C ratio >2.3 and the mean maximum NC/C ratio differed significantly between gender but not between age groups. An increasing NC/C ratio was associated with a significant decrease in EF (r=-0.21; p<0.05). CONCLUSION:A considerable amount of healthy volunteers fulfils the current diagnostic criteria of LV noncompaction with female subjects showing a higher fraction of false-positive results than males. LV trabeculated volume is more pronounced in young subjects and declines with age. The use of age- and gender-specific reference values as provided in this study may facilitate the delineation of physiological and pathological findings.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

André F,Burger A,Loßnitzer D,Buss SJ,Abdel-Aty H,Gianntisis E,Steen H,Katus HA

doi

10.1016/j.ijcard.2015.03.065

subject

Has Abstract

pub_date

2015-04-15 00:00:00

pages

240-7

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(15)00303-4

journal_volume

185

pub_type

杂志文章

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Reference values for left and right ventricular trabeculation and non-compacted myocardium.