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A pragmatic approach to the use of inotropes for the management of acute and advanced heart failure: An expert panel consensus.

Abstract：

:Inotropes aim at increasing cardiac output by enhancing cardiac contractility. They constitute the third pharmacological pillar in the treatment of patients with decompensated heart failure, the other two being diuretics and vasodilators. Three classes of parenterally administered inotropes are currently indicated for decompensated heart failure, (i) the beta adrenergic agonists, including dopamine and dobutamine and also the catecholamines epinephrine and norepinephrine, (ii) the phosphodiesterase III inhibitor milrinone and (iii) the calcium sensitizer levosimendan. These three families of drugs share some pharmacologic traits, but differ profoundly in many of their pleiotropic effects. Identifying the patients in need of inotropic support and selecting the proper inotrope in each case remain challenging. The present consensus, derived by a panel meeting of experts from 21 countries, aims at addressing this very issue in the setting of both acute and advanced heart failure.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Farmakis D,Agostoni P,Baholli L,Bautin A,Comin-Colet J,Crespo-Leiro MG,Fedele F,García-Pinilla JM,Giannakoulas G,Grigioni F,Gruchała M,Gustafsson F,Harjola VP,Hasin T,Herpain A,Iliodromitis EK,Karason K,Kivikko M,Liau

doi

10.1016/j.ijcard.2019.09.005

subject

Has Abstract

pub_date

2019-12-15 00:00:00

pages

83-90

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(19)32502-1

journal_volume

297

pub_type

杂志文章

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