Abstract:
BACKGROUND:Since the body of evidence addressing the coagulation derangements caused by Coronavirus disease (COVID-19) has been constantly growing, we investigated whether pre-hospitalization oral anticoagulation (OAC) or in-hospital heparin treatment could have a protective role among COVID-19 patients. METHOD:In this cohort study, consecutive COVID-19 patients admitted to four different Italian Institutions were enrolled. Baseline demographic, clinical, laboratory, and radiological characteristics, as well as in-hospital treatment and outcomes were evaluated. The primary outcome was mortality. RESULTS:A total of 844 COVID-19 patients were enrolled as study cohort, n = 65 (7.7%) taking OACs prior to hospitalization. Regarding clinical outcomes, OAC patients developed acute hypoxemic respiratory failure (AHRF) more frequently than non-OAC patients as well as presenting a higher mortality rate (44.6% vs 19.8%, p < 0.001). At overall multivariate logistical regression, use of heparin (n = 394, 46.6%) was associated with a better chance of survival to hospital discharge (OR 0.60 [0.38-0.94], p < 0.001), in particular in patients with AHRF, with no association found with the use of OACs. In a sub-analysis, the highest mortality rate was found for AHRF patients when heparin was not administered. CONCLUSION:In our cohort, OACs appeared to be ineffective in reducing mortality rate, while heparin resulted to be a useful treatment when lung disease was sufficiently severe, potentially suggesting a crucial role of microthrombosis in severe COVID-19. Due to the relatively small number of COVID-19 patients treated with OACs included in our analysis and their higher number of comorbidities, larger studies are needed in order to confirm our findings.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Schiavone M,Gasperetti A,Mancone M,Curnis A,Mascioli G,Mitacchione G,Busana M,Sabato F,Gobbi C,Antinori S,Galli M,Forleo GBdoi
10.1016/j.ijcard.2020.09.001subject
Has Abstractpub_date
2021-01-15 00:00:00pages
276-280eissn
0167-5273issn
1874-1754pii
S0167-5273(20)33735-9journal_volume
323pub_type
杂志文章,多中心研究abstract:BACKGROUND:The long-term prognosis of vasospastic angina (VSA) patients presenting with aborted sudden cardiac death (ASCD) is still unknown. We sought to compare the long-term clinical outcomes between VSA patients presenting with and without ASCD by retrospective analysis of a nationwide population-based database. M...
journal_title:International journal of cardiology
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journal_title:International journal of cardiology
pub_type: 杂志文章,评审
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doi:10.1016/j.ijcard.2006.07.012
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abstract::A 37-yr-old woman with an 8-month history of chest pain, unrelated to exercise, was successfully resuscitated from out-of-hospital cardiac arrest due to ventricular fibrillation. Cardiac catheterisation revealed minor coronary artery disease. Ergometrine injection was associated with complete occlusion of the left ant...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2008.11.106
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pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2014.06.027
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journal_title:International journal of cardiology
pub_type: 信件
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journal_title:International journal of cardiology
pub_type: 信件
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 杂志文章
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journal_title:International journal of cardiology
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doi:10.1016/j.ijcard.2014.03.176
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journal_title:International journal of cardiology
pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1016/j.ijcard.2006.11.013
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doi:10.1016/j.ijcard.2016.12.027
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(92)90022-u
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(96)02872-0
更新日期:1997-02-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,评审
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更新日期:2017-02-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2015.07.057
更新日期:2015-11-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(98)00251-4
更新日期:1998-11-30 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2003.05.025
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