Abstract:
BACKGROUND:The characteristics of unique ECG findings in the Brugada syndrome have not been well explained. METHODS:To clarify their characteristics and mechanisms, body surface maps (BSM) were recorded from patients with the Brugada syndrome (13 cases; a mean age of 48 years) before and after administration of isoproterenol (ISP) or Na channel blockers (12 cases). RESULTS:ST elevation in V1-V3 was decreased by 0.1 mV or more after ISP infusion in 8 of 11 cases and elevated after Na channel blockers in 8 of 12. In ventricular activation time (VAT) isochronal map, delayed conduction was noted on upper anterior chest in 11 and on anterior left chest in two. Delayed conduction areas were decreased by ISP and expanded by Na channel blockers. QRST isointegral map showed normal findings in baseline with minimal changes after ISP or Na channel blockers. Activation recovery interval (ARI) isochronal map showed prolonged area on upper anterior chest in baseline, being reduced by ISP and expanded by Na channel blockers. ARI dispersion (ARI-d), defined as difference between the maximum and minimum value of ARI, was larger in Brugada patients than that of normal subjects in baseline, and decreased after ISP and increased after Na channel blockers. CONCLUSION:ST elevation in the Brugada syndrome is primarily caused by abnormality in depolarization rather than in repolarization. BSM can provide better information to clarify a mechanism of ECG changes adding its diagnostic value for this unique syndrome.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Izumida N,Asano Y,Doi S,Wakimoto H,Fukamizu S,Kimura T,Ueyama T,Sakurada H,Kawano S,Sawanobori T,Hiraoka Mdoi
10.1016/j.ijcard.2003.05.025subject
Has Abstractpub_date
2004-06-01 00:00:00pages
261-8issue
2-3eissn
0167-5273issn
1874-1754pii
S0167527303004224journal_volume
95pub_type
杂志文章abstract::Pulmonary arterial hypertension is an obstructive pulmonary vasculopathy that leads to increased pulmonary vascular resistance, right ventricular overload and failure, and death. Patients' clinical status and prognosis depend mostly on the capability of the right ventricle to adapt to the increased afterload, maintain...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2019.10.043
更新日期:2020-02-15 00:00:00
abstract:BACKGROUND:Heart failure with preserved ejection fraction (HFpEF) is among the most common forms of heart failure (HF). We aimed to investigate the prognostic significance of serum potassium levels and its interaction with type-2 diabetes mellitus in patients with HFpEF. METHODS:Consecutive HFpEF patients were prospec...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2020.04.029
更新日期:2020-10-15 00:00:00
abstract:BACKGROUND:In addition to lowering lipid profile, statins have pleiotropic effects on improving vascular function. Changes of these pleiotropic effects and their relationship to lipid profile after withdrawal of statin treatment remained unclear. METHODS:We investigated the changes of lipid profile and plasma concentr...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2003.11.023
更新日期:2005-02-28 00:00:00
abstract:AIMS:Heart failure (HF) is the most common complication of patients with atrial fibrillation (AF), but possible risk factors or health consequences are not well described. Low kidney function is a risk factor for both AF and HF. We evaluated estimated glomerular filtration rate (eGFR) as a predictor of HF in patients w...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2020.08.003
更新日期:2020-12-01 00:00:00
abstract::A large family with a new phenotype of conduction system disease including heart blocks and preexcitation associated with hypertrophic cardiomyopathy and transmitted in an autosomal dominant pattern is described. ...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2006.12.050
更新日期:2008-04-25 00:00:00
abstract::An analysis of the Coronary Artery Surgery Registry (CASS) was performed to determine the occurrence of stroke after coronary artery bypass surgery in patients entered into the Coronary Artery Surgery Study Registry. Of the 10,098 patients having coronary artery bypass surgery at the Coronary Artery Surgery Study part...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/0167-5273(92)90009-r
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND:Previous studies have shown that control of cardiovascular risk factors deteriorates among residents after a natural disaster. This study assessed the hypothesis that the prevalence of atrial fibrillation (AF) increased among residents in the evacuation zone of Fukushima prefecture after the Great East Japan...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2015.06.151
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to assess stressechocardiography (SE) for risk stratification of asymptomatic type 2 diabetic patients (DM2) without known coronary artery disease CAD. METHODS:A total of 211 consecutive, asymptomatic DM2 patients underwent exercise (n=177) or dobutamine (n=34) SE and were foll...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2007.07.085
更新日期:2009-01-09 00:00:00
abstract::The present study was performed to evaluate how to assess cardiac resynchronization therapy (CRT) efficacy in chronic heart failure (CHF) through clinical, echocardiographic and exercise analysis. We analyzed 41 stable CHF (NYHA III) patients with: left bundle-branch-block, ejection fraction <35%, left-ventricular dis...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2008.04.052
更新日期:2009-08-14 00:00:00
abstract:BACKGROUND:Limited data are available to assess whether access to and quality of cardiovascular disease (CVD) care are comparable among men and women in India. We analyzed data from the American College of Cardiology's PINNACLE (Practice Innovation and Clinical Excellence) India Quality Improvement Program (PIQIP) to e...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.04.058
更新日期:2016-07-15 00:00:00
abstract:BACKGROUND:While some case-control studies have showed the correlation between the hypertriglyceridemic waist (HTGW) phenotype (increased WC and hypertriglyceridemia) and cardiovascular disease (CVD) events, there are few data regarding this correlation in cohort studies, especially in Asian populations that have a hig...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.03.177
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Early angiotensin-converting enzyme (ACE) inhibition is able to re-program spontaneously hypertensive rats (SHR) to express an attenuated form of disease in adulthood. METHODS:Three groups of animals (n=5 each) were studied: Wistar male rats, SHR males, and SHR males obtained from dams treated with enalapri...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2004.03.029
更新日期:2005-05-25 00:00:00
abstract:BACKGROUND:It is known that coronary heart surgery leads to varying degrees of cardiac autonomic derangement, clinically detectable as depression of heart rate variability (HRV) parameters. Few studies report that also surgical replacement of the aortic valve (SAVR) may lead to HRV abnormalities, while very little is k...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2015.06.004
更新日期:2015-10-15 00:00:00
abstract:BACKGROUND:Proximal aortic dilatation in certain congenital heart diseases (CHD) prompts concerns about dissection and consideration of prophylactic surgery. To evaluate contemporary prophylactic practice, we determined incidence of aortic dissection and prophylactic surgery in aortopathy-associated CHD, compared to Ma...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.09.038
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:The prevalence of congenital heart disease (CHD) in the adult population is steadily increasing. A substrate of prosthetic material and residual lesions, constantly evolving as surgical techniques change over time, predispose these patients to the potentially devastating complication of infective endocarditi...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.08.035
更新日期:2017-12-15 00:00:00
abstract:UNLABELLED:To determine the clinical value of several parameters derived by application of the proximal isovelocity surface area method in the assessment of mitral regurgitation (MR), 28 consecutive patients with angiographic diagnosis of MR underwent color Doppler echocardiography within 48 h of cardiac catheterizatio...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(98)00355-6
更新日期:1999-02-28 00:00:00
abstract::Left ventricular outflow tract obstruction can occur at the supravalvular, valvular, or subvalvular level. Each level of obstruction is associated with distinct symptomatology, natural history, and operative approach. We describe a case of asymptomatic double site of left ventricular outflow tract obstruction: subvalv...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.08.107
更新日期:2009-03-20 00:00:00
abstract:PURPOSE:It is thought that the mechanisms responsible for impaired chronotropic response to exercise are related to disturbance of cardiovascular autonomic regulation such as the baroreflex. However, it is still unclear whether the baroreflex mechanisms modulate heart rate (HR) responses to exercise via vagal and/or sy...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2003.12.007
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:Drug eluting balloons (DEB) have been developed to overcome the limitations of drug eluting stents (DES), but clinic results of various DEB studies are still not consistent. Thus, we performed a meta-analysis to compare outcomes of DEB and DES for the treatment of coronary artery disease (CAD). METHODS:Medl...
journal_title:International journal of cardiology
pub_type: 杂志文章,meta分析
doi:10.1016/j.ijcard.2013.07.161
更新日期:2013-10-12 00:00:00
abstract:OBJECTIVE:Angiotensin-converting enzyme inhibitor (ACEI) is beneficial in patients with congestive heart failure (CHF). Some, but not all, angiotensin receptor blocker (ARB) was demonstrated to be effective as "add-on" therapy. We investigated whether irbesartan is useful as an add-on therapy in CHF. DESIGN:Randomized...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.ijcard.2007.02.016
更新日期:2008-03-28 00:00:00
abstract::The objective of this study was to prospectively investigate various clinical and echocardiographic variables to predict the left atrial and left atrial appendage clot and spontaneous echo contrast in patients with severe rheumatic mitral stenosis. We studied 200 consecutive patients (112 males and 88 females; mean ag...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(00)00235-7
更新日期:2000-05-31 00:00:00
abstract::A 78-year-old man was admitted with sudden onset of dyspnea followed by syncope. Contrast-enhanced computed tomography showed embolism in the right main pulmonary artery and left upper pulmonary artery. Echocardiography revealed a large, free-floating thrombus and cine magnetic resonance imaging showed highly mobile, ...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.06.140
更新日期:2008-09-26 00:00:00
abstract:BACKGROUND:To investigate the contribution of individual and population factors to Coronary Heart Disease (CHD) mortality rates in Ireland between 2000 and 2015. METHODS:The Irish IMPACT CHD model was utilized with CHD Deaths Prevented or Postponed (DPPs) as outcome. RESULTS:CHD mortality rates in Ireland in those ag...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2020.03.067
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Metabolic syndrome (MetS) is associated with a substantially increased risk for cardiovascular disease and diabetes. We examined the contribution of length of residence, socioeconomic position and lifestyle-related factors to the differences in the prevalence of MetS among migrants compared with Finns. METH...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2017.01.051
更新日期:2017-04-01 00:00:00
abstract::A case of left parasternal systolic lift due to isolated infarction of the right ventricular anterior wall is reported. This cause of a left parasternal lift should also be considered while examining a case of myocardial infarction. ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(93)90106-q
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND:Coronary heart disease (CHD) development is complex in origin, with contributions from well-defined lifestyle and not well-determined genetic risk factors. The aim of this study is to report the relationship between certain SNPs and the risk of cardiovascular (CV) complications in patients with CAD confirmed...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.11.060
更新日期:2017-02-01 00:00:00
abstract:AIMS:Vascular smooth muscle cell (VSMC) migration, proliferation and remodeling of the extracellular matrix contribute to lumen loss after arterial injury leading to restenosis. Several studies indicated the role of the cyclic guanosine monophosphate signaling in neointimal formation. Cinaciguat, the novel soluble guan...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2012.01.032
更新日期:2013-07-31 00:00:00
abstract:BACKGROUND:The associations between autonomic function and biventricular function in patients with the indeterminate form of Chagas disease remains to be elucidated. METHODS:In 42 asymptomatic patients and 19 healthy volunteers, the autonomic function was assessed by time domain indices of heart rate variability (HRV)...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2005.11.010
更新日期:2006-11-10 00:00:00
abstract:BACKGROUND:Adenosine administered as an adjunct to reperfusion can reduce coronary no-reflow and limit myocardial infarct (MI) size in ST-segment elevation myocardial infarction (STEMI) patients. Whether adjunctive adenosine therapy can improve clinical outcomes in reperfused STEMI patients is not clear and is investig...
journal_title:International journal of cardiology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.ijcard.2015.09.005
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:The glycoprotein IIb/IIIa antagonists (GPAs) represent a new class of drugs to prevent platelet aggregation in the acute treatment of non-ST-elevation acute coronary syndromes (NSTE-ACS). Systematic reviews have identified serious limitations in published cost-effectiveness analyses, including a lack of UK-s...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2004.08.042
更新日期:2005-04-20 00:00:00