Abstract:
BACKGROUND:In addition to lowering lipid profile, statins have pleiotropic effects on improving vascular function. Changes of these pleiotropic effects and their relationship to lipid profile after withdrawal of statin treatment remained unclear. METHODS:We investigated the changes of lipid profile and plasma concentrations of human soluble vascular cell adhesion molecule-1 (sVCAM-1) and human tissue type plasminogen activator (tPA) after withdrawal of statin treatment. Twenty-two patients (14 F, 8 M, aged 63+/-13 years) with hypercholesterolemia were treated with atorvastatin (ATOR; 10 mg/day) for 12 weeks. Blood samplings for serum lipid and markers were collected before, after and withdrawal of statin treatment. RESULTS:The total cholesterol, LDL-cholesterol and sVCAM-1 (from 394.4+/-251.7 to 321.0+/-198.9 ng/ml, p<0.05) all decreased significantly and the tPA (from 9.47+/-3.57 to 11.62+/-3.99 ng/ml, p<0.05) increased significantly after atorvastatin treatment. During the following 3 days after withdrawal of atorvastatin, the total cholesterol and LDL-cholesterol did not show any significant change. However, the plasma sVCAM-1 significantly elevated on day 2 (from 321.0+/-198.9 to 371.2+/-220.4 ng/ml, p<0.05) and the plasma tPA significantly decreased on day 1 (from 11.62+/-3.99 to 10.52+/-3.55 ng/ml, p<0.05) and day 3 (from 11.62+/-3.99 to 10.27+/-3.69 ng/ml, p<0.05). Both the significant elevation of sVCAM-1 and decrease of tPA after withdrawal of atorvastatin treatment occurred within 3 days, while the serum cholesterol and LDL-chol levels did not have any significant change and were still within the therapeutic range. CONCLUSIONS:After 12 weeks of atorvastatin treatment, the beneficial pleiotropic effects can be demonstrated simultaneously with lowering the lipid profile. However, after withdrawal of atorvastatin, the beneficial pleiotropic effects are abrogated rapidly within days and are independent on elevation of serum cholesterol.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Lai WT,Lee KT,Chu CS,Voon WC,Yen HW,Tsai LY,Sheu SHdoi
10.1016/j.ijcard.2003.11.023subject
Has Abstractpub_date
2005-02-28 00:00:00pages
459-64issue
3eissn
0167-5273issn
1874-1754pii
S0167527304001305journal_volume
98pub_type
杂志文章abstract::Left ventricular outflow tract obstruction caused by a discrete subaortic membrane in a young female was successfully dilated using an Inoue balloon catheter. The Inoue balloon catheter was used in a retrograde manner via the femoral artery. ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(96)02579-x
更新日期:1996-04-19 00:00:00
abstract:BACKGROUND:This study aims to assess time trends in first hospitalization for heart failure (HF) in a community-based population over the period from 1977 to 2014. METHODS:Population-based cohort study using resources from the "Martignacco project" started in 1977 and promoted by the WHO. Three thousand and sixty-six ...
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journal_title:International journal of cardiology
pub_type: 杂志文章
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abstract::We evaluated characteristics and prevalence of ST-segment depression and/or T-wave inversion in the resting electrocardiogram of 244 consecutive patients with acute ischemic stroke, but without ischemic heart disease. The prevalence of ST-T changes ranged from 13% to 16% and this is what to expect in the background po...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.05.055
更新日期:2008-08-01 00:00:00
abstract::Pregnancy can precipitate cardiac arrhythmias not previously present in seemingly well individuals. Risk of arrhythmias is relatively higher during labor and delivery. Potential factors that can promote arrhythmias in pregnancy and during labor and delivery include the direct cardiac electrophysiological effects of ho...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/s0167-5273(02)00601-0
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abstract:BACKGROUND:Hemoconcentration is a surrogate marker of effective decongestion and diuresis therapy. Recently, hemoconcentration has been associated with decreased mortality and rehospitalization in heart failure (HF) patients. However, the prognostic power of hemoconcentration in a large sample-sized HF cohort was limit...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
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abstract::In this study, the effect of celiprolol (beta-1-antagonist with beta-2-agonistic activity) on hemodynamic and electrocardiographic parameters of patients with congestive heart failure due to ischemic (iCMP) and non-ischemic (niCMP) origin should be evaluated. Sixteen patients were included into the study, nine with iC...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
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更新日期:1999-03-15 00:00:00
abstract:BACKGROUND:QTc interval (QTc) prolongation is seen on the post-arrest electrocardiogram (ECG) of many out of hospital cardiac arrest (OHCA) survivors. It remains unclear whether this is a transient phenomenon or a manifestation of an underlying arrhythmic substrate. This observational study assessed the trend of QTc in...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2020.08.090
更新日期:2021-01-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2006-08-10 00:00:00
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2008.11.097
更新日期:2010-04-30 00:00:00
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journal_title:International journal of cardiology
pub_type: 历史文章,杂志文章,收录出版
doi:10.1016/j.ijcard.2009.04.045
更新日期:2010-02-04 00:00:00
abstract::In a retrospective study of 172 patients with juvenile rheumatoid arthritis, symptomatic cardiac involvement occurred in 13 (7.6%) patients (11 systemic and 2 polyarticular). There was predominance of the male sex and in most patients the involvement occurred in the initial years of the disease. Pericarditis occurred ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(92)90082-e
更新日期:1992-01-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,评审
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更新日期:2015-12-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 评论,信件
doi:10.1016/j.ijcard.2009.03.125
更新日期:2011-02-17 00:00:00
abstract:BACKGROUND:To distinguish left ventricular outflow tract (LVOT) from right ventricular outflow tract (RVOT) origin in idiopathic outflow tract premature ventricular contractions (IOT-PVCs) patients with precordial R/S transition at lead V3 is still a challenge. We sought to develop a new electrocardiography (ECG) metho...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.07.045
更新日期:2018-10-15 00:00:00
abstract:AIMS:Microvascular obstruction (MVO) is associated with a worse prognosis in patients with ST-elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PCI). However, data about incidence, clinical outcome and correlates of MVO in latecomers after STEMI are still lacking. METHODS:W...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.02.023
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Multiple studies have sought to determine variables associated with improved "response" to cardiac resynchronization therapy(CRT). Such variables, however, are often derived from inadequately controlled, single center cohort studies calling external validity into question. We sought to determine predictors o...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2016.09.078
更新日期:2016-12-15 00:00:00
abstract:BACKGROUND:The long-term prognosis of vasospastic angina (VSA) patients presenting with aborted sudden cardiac death (ASCD) is still unknown. We sought to compare the long-term clinical outcomes between VSA patients presenting with and without ASCD by retrospective analysis of a nationwide population-based database. M...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.09.082
更新日期:2018-12-15 00:00:00
abstract:OBJECTIVE:Free fatty acid inhibition with trimetazidine (TMZ) improves myocardial metabolism and myocardial ischemia in patients with coronary artery disease (CAD). Because of its effect on myocardial glucose utilization TMZ may represent a therapeutic option in diabetic patients with CAD. Aim of the present study was ...
journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijcard.2006.08.082
更新日期:2007-08-09 00:00:00
abstract::Vein of Galen Aneurismal Malformation (VGAM), a rare congenital anomaly, can lead to congestive heart failure (CHF) and persistent pulmonary hypertension (PHT). Inotropic drugs, diuretics, mechanical ventilation or inhaled nitric oxide (iNO) are the main therapeutic strategies but often do not suffice to control the s...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.08.020
更新日期:2009-02-20 00:00:00
abstract:OBJECTIVES:Assessment of the long term outcome of mechanical valve prosthesis at pulmonary position in a population of grown-up congenital heart disease patients from a tertiary referral center. METHODS:From 1977 to 2007, 22 consecutive patients underwent a total of 25 pulmonary valve replacements with mechanical pros...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2010.04.004
更新日期:2011-07-15 00:00:00
abstract:BACKGROUND:The choice of antithrombotic prophylaxis in the so-called "medium-risk" patients (i.e., CHA2DS2-VASc score = 1 in males or 2 in females) is one of the major enigmatic issues in clinical management of atrial fibrillation (AF). METHODS:We retrospectively evaluated 30-day and 1-year thromboembolic events in al...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2019.04.057
更新日期:2019-08-01 00:00:00
abstract::Acute stress-induced cardiomyopathy is a syndrome originally described in Japan but increasingly recognized all over the world. Patients typically present with chest pain triggered by an intense emotional or physiological stressor, electrocardiographic changes, and mild cardiac enzyme elevation. Patients typically ret...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.12.105
更新日期:2009-05-15 00:00:00
abstract:BACKGROUND:CT coronary angiography (CTA) with 64 slice multi-detector CT (64-MDCT) has assumed an increasing role in clinical practice; however the high radiation dose associated with retrospective ECG-gated CTA has led to suggestions that a low dose prospectively gated strategy may be more appropriate. This study aims...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2009.09.542
更新日期:2011-03-17 00:00:00
abstract:BACKGROUND AND AIM:The problem of a possible gender bias in coronary heart disease management is still controversial. We studied gender differences in secondary preventive drug prescriptions and in referral to cardiac rehabilitation after acute coronary events in France. METHODS:An observational survey was carried out...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2003.04.003
更新日期:2004-02-01 00:00:00
abstract:BACKGROUND:Myocardial infarction (MI) is one of the most common causes of cardiac morbidity and mortality. Many evidences suggest that hypothermia have a more pronounced impact as an adjunctive therapy for MI to reduce infarct size. However, the function of long non-coding RNAs (lncRNA) in therapeutic hypothermia for M...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.12.097
更新日期:2018-09-01 00:00:00
abstract::Several trials have targeted neutral endopeptidase to demonstrate benefits for patients with heart failure. In the PARADIGM-HF trial, a combination of sacubitril and valsartan was superior to enalapril in reducing the risk of death and of hospitalization for heart failure. In this editorial we apply the trial to heart...
journal_title:International journal of cardiology
pub_type: 社论
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更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Alterations in coronary vasomotor tone may participate in the pathogenesis of acute myocardial infarction (AMI). Vascular ATP-sensitive K(+) (KATP) channels, formed by Kir6.x/SUR2B, are key regulators of coronary tone and mutations in cardiac (Kir6.2/SUR2A) KATP channels result in heart disease. Here we expl...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2013.04.210
更新日期:2013-10-09 00:00:00
abstract:BACKGROUND:Postoperative new-onset atrial fibrillation (PNAF) is the most common complication following cardiac surgery. The inflammatory response, as a potential underlying mechanism, has been extensively studied. In small studies, the white blood cell count (WBC) has been shown to be the only consistent inflammatory ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.11.038
更新日期:2017-02-01 00:00:00