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Clinical outcome and correlates of coronary microvascular obstruction in latecomers after acute myocardial infarction.

Abstract：

AIMS:Microvascular obstruction (MVO) is associated with a worse prognosis in patients with ST-elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PCI). However, data about incidence, clinical outcome and correlates of MVO in latecomers after STEMI are still lacking. METHODS:We prospectively enrolled consecutive patients that were latecomers after STEMI (symptoms onset >12h) undergoing PCI. We performed an angiographic analysis to assess the occurrence of MVO [defined as TIMI flow grade ≤2 or 3 with a myocardial blush grade <2]. Moreover, we performed a clinical and echocardiographic follow-up to assess the occurrence of major adverse cardiovascular events (MACE), defined as the composite of cardiac death, myocardial infarction and rehospitalization for heart failure, and to evaluate left ventricle remodelling. RESULTS:Seventy-eight patients were enrolled [mean age 67.58±11.72years, 57 (73%) male; mean time of symptom onset 23.14±16.06h] with a mean follow-up time of 29.7±14.1months. MVO occurred in 39 (50%) patients. Patients with MVO had a higher rate of MACE [18 (46%) vs. 3 (8%), p<0.001] and LV remodelling [25 (64%) vs. 6 (15%), p<0.001] compared with patients without MVO. By multivariable Cox regression MVO and left anterior descending artery were independent predictors of MACE. CONCLUSIONS:Latecomers after STEMI have a high risk to develop MVO that is related to an adverse prognosis. Appropriate management and follow-up strategies should be implemented in such high-risk patients group.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Montone RA,Niccoli G,Minelli S,Fracassi F,Vetrugno V,Aurigemma C,Burzotta F,Porto I,Trani C,Crea F

doi

10.1016/j.ijcard.2017.02.023

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

30-35

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(16)34261-9

journal_volume

236

pub_type

杂志文章

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