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Allopurinol, benzbromarone and risk of coronary heart disease in gout patients: A population-based study.

Abstract：

BACKGROUND:The effect of gout on the risk of developing coronary artery disease (CAD) is uncertain. Some studies have found that gout is a risk factor for acute myocardial infarction. This study examined the changes in risk of CAD in gout patients taking allopurinol and/or benzbromarone, and analyzed the dose-response relationship of both drugs with CAD incidence. METHODS:The medical records of one million subjects from 2000 to 2011 were provided by the Taiwan National Health Insurance Research Database. Cox proportional hazard ratio was used to compare the risk of CAD in gout patients taking allopurinol or/and benzbromarone with those taking neither drug. Hazard ratios (HR) were adjusted for possible confounding factors, including age, gender, hypertension, hyperlipidemia, diabetes mellitus, chronic kidney disease, and relevant medications. RESULTS:Of 8047 gout patients, 1422 were treated with allopurinol (Group A), 4141 with benzbromarone (Group B), and 2484 with both drugs (Group A/B) during the follow-up period. Our results showed the incidence of CAD after adjusting for covariates for Group A, Group B, and Group A/B did not significantly differ from the comparison group. However, after adjustment for covariates in dose-response analyses, treatment with over 270 defined daily doses (DDDs) of allopurinol, and over 360 DDDs of benzbromarone, was associated with a significantly reduced risk of CAD. CONCLUSION:We found that the use of allopurinol and benzbromarone, whether alone or in combination, had a linear dose-response relationship between the numbers of defined daily doses and the risk of CAD, especially in higher DDDs.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Lin HC,Daimon M,Wang CH,Ho Y,Uang YS,Chiang SJ,Wang LH

doi

10.1016/j.ijcard.2017.02.013

subject

Has Abstract

pub_date

2017-04-15 00:00:00

pages

85-90

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(17)30691-5

journal_volume

233

pub_type

杂志文章,随机对照试验

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