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Vessel dilator is associated with survival after acute myocardial infarction.

Abstract：

:To assess whether infarct size, ischemic area and/or survival correlates with circulating atrial natriuretic peptides (long acting sodium stimulator, vessel dilator, or atrial natriuretic factor), these peptides were measured in a canine model of acute myocardial infarction. Elevations in the circulating concentrations of atrial natriuretic factor, vessel dilator, and long acting sodium stimulator were significant (P < 0.05) within 6 min of coronary occlusion of the left anterior descending coronary artery. The percentage of ischemic myocardium ranged from 20 to 67% with a mean of 37 +/- 17%. The area of infarction ranged from 1 to 13% with the infarcted area of non-survivors being twice that of survivors. Both the ischemic and infarcted areas correlated (P < 0.05) with the circulating concentrations of these atrial natriuretic peptides. Survival correlated also with the circulating plasma concentrations of vessel dilator, atrial natriuretic factor and long acting sodium stimulator (P < 0.05). When these circulating concentrations were evaluated, however, by determining their area under their respective concentrations curves and expressing each as the log area under plasma concentration-time curve (area under the curve) per kg of weight (Y = 58.48X-23.62; r = 0.825; P = 0.0009), vessel dilator was the only atrial natriuretic peptide that correlated with survival.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Ackerman BH,Wyeth RP,Soulsby ME,Pappas AA,Vesely DL

doi

10.1016/0167-5273(94)02192-l

subject

Has Abstract

pub_date

1995-01-06 00:00:00

pages

235-44

issue

3

eissn

0167-5273

issn

1874-1754

pii

016752739402192L

journal_volume

47

pub_type

杂志文章

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