Abstract:
OBJECTIVES:To examine the association between health-related quality of life (HRQoL) and mortality in patients with heart failure (HF). BACKGROUND:The potential association of HRQoL and mortality in patients with HF is unclear. We investigated this association in The Danish Study to Assess the Efficacy of Implantable Cardioverter Defibrillators (ICD) in Patients with Non-ischemic Systolic Heart Failure on Mortality (DANISH). METHODS:In DANISH, a total of 1116 patients with non-ischemic systolic HF on guideline-recommended therapy were randomized to ICD therapy or usual clinical care. HRQoL was assessed at randomization using the disease-specific Minnesota Living with Heart Failure Questionnaire (MLHFQ, 0-105, high score indicating worse HRQoL). Multivariable Cox proportional hazard models were used to compare hazard ratios (HR) for all-cause mortality according to MLHFQ above or below 45, as recommended by a recent meta-analysis, to identify patients with poor HRQoL. RESULTS:HRQoL was completed by 935 (84%) patients at baseline with a median follow-up of 67 months (IQR 47-83). Patients with poor HRQoL (MLHFQ score > 45, median 60 (IQR 53-71),n = 350) had a higher incidence of all-cause mortality than patients with moderate/good HRQoL (MLHFQ ≤45, median 23 (IQR 13-33), n = 585), respectively 26% vs. 18% with an unadjusted HR of 1.57 (95% CI 1.19-2.08, p = .002), and an adjusted HR of 1.39 (95% CI 1.01-1.91, p = .04). CONCLUSION:Poor HRQoL was associated with an increased risk of all-cause mortality after adjustment for traditional risk factors. CLINICAL TRIAL REGISTRATION:https: //clinicaltrials.gov/ct2/show/NCT00542945(DANISH).
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Bundgaard JS,Thune JJ,Gislason G,Fosbøl EL,Torp-Pedersen C,Aagaard D,Nielsen JC,Haarbo J,Thøgersen AM,Videbæk L,Jensen G,Olesen LL,Kristensen SL,Pedersen SS,Køber L,Mogensen UMdoi
10.1016/j.ijcard.2020.02.008subject
Has Abstractpub_date
2020-04-15 00:00:00pages
92-98eissn
0167-5273issn
1874-1754pii
S0167-5273(19)33648-4journal_volume
305pub_type
杂志文章abstract::Recent studies have demonstrated the potential for myocardial regeneration at the time of myocardial infarction. Our lab focuses on understanding how stem cells home to injured tissue. We believe that a detailed analysis of the biological responses to tissue injury not only gives us insight into how damage occurs, but...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(04)90007-1
更新日期:2004-06-01 00:00:00
abstract::Despite significant advances in the last 30 years in reducing morbidity and mortality from heart failure with reduced ejection fraction (HFrEF) with pharmacological and device-based therapies, patients remain at a high risk of adverse cardiovascular outcomes. Sacubitril/valsartan, a first-in-class angiotensin receptor...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2018.05.124
更新日期:2019-04-15 00:00:00
abstract:OBJECTIVE:Oxidative stress seems to play a role in impairing flow-mediated dilation (FMD) in patients with peripheral artery disease (PAD) but the underlying mechanism is still undefined. We evaluated whether NOX2, the catalytic core of NADPH oxidase, the most important producer of reactive oxidant species (ROS), is im...
journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijcard.2012.01.069
更新日期:2013-04-30 00:00:00
abstract:BACKGROUND:Multiple studies have sought to determine variables associated with improved "response" to cardiac resynchronization therapy(CRT). Such variables, however, are often derived from inadequately controlled, single center cohort studies calling external validity into question. We sought to determine predictors o...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2016.09.078
更新日期:2016-12-15 00:00:00
abstract::To examine whether smoking cessation would improve the short-term prognosis for patients with variant angina, 37 smokers with variant angina who were discharged after the complete disappearance of angina by medical treatment with calcium blockers were advised to stop smoking and were followed-up for 1 year. Urinary co...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(94)90019-1
更新日期:1994-04-01 00:00:00
abstract::We reviewed the reports of 27 patients who had an aortic valve replacement after previous coronary artery bypass grafting. The aortic valve disease -- mainly aortic stenosis -- showed a rapid rate of progression. In the time interval between coronary artery bypass grafting and aortic valve replacement of 4.6+/-2.2 yea...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(98)00018-7
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND:To determine the cardiological substrate in acute stroke patients presenting with a cardioembolic stroke subtype. METHODS:Data of 402 consecutive patients with cardioembolic stroke (cerebral infarction, n=347; transient ischaemic attack, n=55) were collected from a prospective hospital-based stroke registry...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2003.02.007
更新日期:2004-06-01 00:00:00
abstract::Serial electrocardiograms as well as echocardiographic studies of 51 pilgrims suffering from acute heat stroke (mean rectal temperature 41.6 degrees C) were performed. All patients were examined immediately after cooling and 24 h later whenever possible. Regional wall motion abnormalities were detected in 9 cases (17....
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(92)90202-e
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:Sleep disordered breathing (SDB) is common in patients with heart failure with reduced ejection fraction (HFrEF). An increased apnea-hypopnea index (AHI) is associated with poor outcomes. We examined whether an analysis of nocturnal desaturations (NDs) can improve the risk stratification. METHODS:Three-hund...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2015.11.108
更新日期:2016-01-15 00:00:00
abstract:BACKGROUND:Platelet hyperreactivity was reported in clopidogrel-naiotave carriers of the H2 haplotype of the P2Y(12) platelet ADP receptor. Here, we studied the influence of this genetic variant on clopidogrel responsiveness. METHODS:ADP-mediated (5 micromol/L) platelet aggregation was determined by impedance (Omega) ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2007.12.118
更新日期:2009-04-17 00:00:00
abstract::This study was designed to investigate the effect of sarpogrelate hydrochloride on impaired endothelium-dependent relaxation (EDR) induced by high glucose in isolated rat aorta. Both acetylcholine-induced EDR and sodium nitroprusside-induced endothelium-independent relaxation (EIR) were measured after the rings were e...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2009.09.539
更新日期:2011-03-17 00:00:00
abstract::Dilated cardiomyopathy is a rare cardiac disease characterized by left ventricular dilatation and systolic dysfunction leading to heart failure and sudden cardiac death. Currently, despite several conditions have been reported as aetiologies of the disease, a large number of cases remain classified as idiopathic. Rece...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2016.09.068
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Left ventricular (LV) global longitudinal strain (GLS) can detect an early dysfunction in arterial hypertension. We investigated regional LV patterns of longitudinal strain (LS) and base-to-apex behaviour in newly diagnosed, never-treated hypertensive patients (HTN) without LV hypertrophy. METHODS:180 HTN a...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2020.01.038
更新日期:2020-04-01 00:00:00
abstract::In the presence of 3-isobutyl-methylxanthine (IBMX), induction of cyclic 3',5'-guanosine monophosphate (GMP) production in human washed platelets (HWP) by nitric oxide donors (NOD) is followed by its accumulation in the surrounding medium in a time- and concentration-dependent manner. Thirty minutes incubation of HWP ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(95)02427-x
更新日期:1995-10-01 00:00:00
abstract::A case is described where severe hypophosphataemia was induced by a widely used protocol for glucose-insulin-potassium (GIK) infusion. Hypophosphataemia was found to be a universal sequel to the use of this infusion. A new regimen for administering this agent was designed, and shown to lack the potentially serious sid...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(88)90051-4
更新日期:1988-03-01 00:00:00
abstract:BACKGROUND:Quantitative flow ratio (QFR) is a novel, adenosine-free method for functional coronary lesion interrogation, which is based on 3-dimensional quantitative coronary angiography and computational algorithms. Data on QFR in all-comer patients with intermediate coronary lesions are scarce, and the diagnostic per...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.11.093
更新日期:2019-03-15 00:00:00
abstract::We examined the distributions of the activation recovery interval (ARI), which is correlated with the local action potential duration (APD), to clarify the origin of the repolarization changes in ASD. The ECGs, QRST isointegral maps and ARI isochronal maps of 21 children with ASD from 3 to 5 years old in age were stud...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
doi:10.1016/s0167-5273(00)00248-5
更新日期:2000-07-31 00:00:00
abstract:BACKGROUND:The components of CHADS2 score were reported to be important risk factors for the development of atrial fibrillation (AF). The goal of the current study was to investigate whether the CHADS2 score was a useful scheme in predicting new-onset AF. Furthermore, we aimed to use the CHADS2 scoring system to estima...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2012.12.011
更新日期:2013-09-30 00:00:00
abstract::Seventy-one patients submitted routinely to coronary artery bypass surgery were randomized into 2 groups. Group A (32 patients) received 24 hr after initiation of surgery an intravenous perfusion of 100 mg of acebutolol given over 24 hr (22 cases) or 600 mg administered orally (10 cases). On subsequent days, they rece...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0167-5273(85)90219-0
更新日期:1985-07-01 00:00:00
abstract::Tumors metastatic to the heart (cardiac metastases) are infrequent and few systematic studies on this topic have been published. Urothelial carcinomas are among the rarest associated with heart metastases and all cases reported to date concern autopsy examinations. We present the first report of urothelial carcinoma m...
journal_title:International journal of cardiology
pub_type: 信件,评审
doi:10.1016/j.ijcard.2008.11.012
更新日期:2010-04-01 00:00:00
abstract::We describe a case in which hyperventilation induced a junctional tachycardia with atrioventricular dissociation. The arrhythmia is interpreted as being due to changes in autonomic nervous tone provoked by the hyperventilation. ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(86)90168-3
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Hepatic and renal dysfunction have been observed in survivors of the Fontan procedure, however their incidence and associated factors remain poorly defined. METHODS:A total of 152 participants from a Registry of 1528 patients underwent abdominal ultrasound, transient elastography (FibroScan), serum fibrosis...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.07.118
更新日期:2018-12-15 00:00:00
abstract:BACKGROUND:After aortic valve replacement (AVR), bicuspid aortic valve (BAV) patients continue to be at risk of aortic complications. Therefore, knowledge of native valve anatomy is important for follow-up. We aimed to determine the extent of which the presence of BAV disease is known in a regional post-AVR population....
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.09.084
更新日期:2016-12-15 00:00:00
abstract:BACKGROUND:The potential role of hydration in prevention of contrast-induced nephropathy (CIN) still remains to be unclear. METHODS:Nine-hundred and thirty-six patients scheduled for percutaneous coronary intervention (PCI) were enrolled into the present study, and divided into normal (serum creatinine<1.5 mg/dl) and ...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ijcard.2007.05.004
更新日期:2008-06-06 00:00:00
abstract::We describe the case of a 91-year-old man who presented with a large pericardial effusion and an intrapericardial mass. Primary malignant pericardial sarcoma was diagnosed by percutaneous pericardial tumor biopsy. The patient died of multiple organ failure three months later. We also review the epidemiology, clinical ...
journal_title:International journal of cardiology
pub_type: 信件,评审
doi:10.1016/j.ijcard.2008.03.097
更新日期:2009-07-24 00:00:00
abstract:INTRODUCTION:Due to fixed dosing of direct oral anticoagulants (DOACs), uncertainty exists about their efficacy in a population of obese/overweight patients. PATIENTS AND METHODS:We retrospectively investigated a real-life cohort of 325 DOAC anticoagulated patients with atrial fibrillation [179 receiving dabigatran (5...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2019.10.035
更新日期:2020-02-15 00:00:00
abstract::Mycobacterium tuberculosis (TB) is a major cause of death globally. TB is capable of infecting every organ in the body, and the heart is no exception. Tuberculous endocarditis (TBE) was first reported in 1892 and subsequently many other cases have been described, highlighting the significant morbidity and mortality as...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2012.08.009
更新日期:2013-08-10 00:00:00
abstract:BACKGROUND:This study examined the accuracy of cardiopulmonary exercise testing (CPET) on a treadmill (TM) and recumbent ergometry (RE) in the predicting coronary artery disease (CAD) severity and prognosis. METHODS:Forty Caucasian subjects, mean age 63.5 ± 7.6, with significant coronary artery lesions (≥50%) were inc...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2019.03.012
更新日期:2019-06-15 00:00:00
abstract::We report a case of a hard lesion in the body of an aortocoronary saphenous vein graft, which developed 3 years after bypass surgery and was not amenable to dilation during percutaneous coronary angioplasty, despite multiple balloon inflations at pressures reaching 13 atm. Hard lesions in aortocoronary saphenous vein ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(95)02460-e
更新日期:1995-11-24 00:00:00
abstract::We describe the case of a 42-year-old woman with a rare combination of congenital pericardial absence, atrial septal defect within the fossa ovalis and sick sinus syndrome. The features of the different examinations performed (chest X-ray, ECG, ambulatory ECG-monitoring, echocardiography, and cardiac catheterization) ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(84)90091-3
更新日期:1984-04-01 00:00:00