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Angiotensin receptor-neprilysin inhibitors: A new paradigm in heart failure with reduced ejection fraction.

Abstract：

:Despite significant advances in the last 30 years in reducing morbidity and mortality from heart failure with reduced ejection fraction (HFrEF) with pharmacological and device-based therapies, patients remain at a high risk of adverse cardiovascular outcomes. Sacubitril/valsartan, a first-in-class angiotensin receptor-neprilysin inhibitors (ARNI), has been shown to reduce the risk of cardiovascular death or heart failure hospitalisation and improve symptoms in patients with chronic, ambulatory, symptomatic HFrEF in a large, phase 3, multicentre, international, randomised controlled trial, PARADIGM-HF, when compared to the gold-standard angiotensin converting enzyme inhibitor, enalapril. This article will review the development of sacubitril/valsartan, the evidence for its use and its current and future role in the management of HFrEF.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Docherty KF,McMurray JJV

doi

10.1016/j.ijcard.2018.05.124

subject

Has Abstract

pub_date

2019-04-15 00:00:00

pages

179-185

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(18)31989-2

journal_volume

281

pub_type

杂志文章,评审

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