Abstract:
BACKGROUND:The role of serum uric acid (SUA) as a risk factor for cardiovascular disease (CVD) remains controversial. Little is known about its predictive value for mortality from congestive heart failure (CHF) and stroke, particularly in elderly, post-menopausal women. METHODS:The relation of SUA to risk of death from total CVD, CHF, stroke and coronary heart disease (CHD) was examined prospectively in a large cohort of 28613 elderly Austrian women (mean age 62.3 years), followed-up for a median of 15.2 years. Adjusted Cox proportional hazards models were calculated to evaluate SUA as an independent predictor for fatal CVD events. RESULTS:SUA in the highest quartile (>or=5.41 mg/dL) was significantly associated with mortality from total CVD (p<0.0001), showing a clear dose-response relationship; the adjusted hazard ratio (95%CI) in comparison to the lowest SUA quartile was 1.35 (1.20-1.52). In subgroup analyses SUA was independently predictive for deaths from acute and subacute (p<0.0001) and chronic forms (p=0.035) of CHD, yielding adjusted hazard ratios for the highest versus lowest SUA quartile of 1.58 (1.19-2.10) and 1.25 (1.01-1.56), respectively. SUA was further significantly related to fatal CHF (p<0.0001) and stroke (p=0.018); the adjusted hazard ratios for the highest versus lowest SUA quartile were 1.50 (1.04-2.17) and 1.37 (1.09-1.74), respectively. CONCLUSIONS:These findings, for the first time, demonstrate that SUA is an independent predictor for all major forms of death from CVD including acute, subacute and chronic forms of CHD, CHF and stroke in elderly, post-menopausal women.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Strasak AM,Kelleher CC,Brant LJ,Rapp K,Ruttmann E,Concin H,Diem G,Pfeiffer KP,Ulmer H,VHM&PP Study Group.doi
10.1016/j.ijcard.2007.11.094subject
Has Abstractpub_date
2008-04-10 00:00:00pages
232-9issue
2eissn
0167-5273issn
1874-1754pii
S0167-5273(07)02133-Xjournal_volume
125pub_type
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journal_title:International journal of cardiology
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2011-10-06 00:00:00
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
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