当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF CARDIOLOGY期刊下所有文献 > Clinical significance of myoglobin and troponin-T in short-lasting severe myocardial ischemia.

Clinical significance of myoglobin and troponin-T in short-lasting severe myocardial ischemia.

Abstract：

BACKGROUND:Myoglobin, cardiac troponin-T and creatine phosphokinase are biochemical indicators of acute coronary syndromes, however, the clinical significance in myocardial ischemia is not well established. Our aim was to elucidate their release kinetics in a well-defined short-lasting myocardial ischemia. METHODS:A coronary sinus lactate study with incremental atrial pacing was performed in 27 patients with significant coronary stenosis. Troponin-T, myoglobin and creatine phosphokinase samples were withdrawn from the coronary sinus and a peripheral vein before, 1, 5, 10, 30, 45 min and 1, 2, 3, 6, 12 h after pacing. RESULTS:Pacing stress induced a severe myocardial ischemia with a duration of 5.8+/-1.6 min, angina pectoris in 22/27, significant ST-segment depressions in 25/27 patients (0.34+/-0.11 mV) and a frank cardiac lactate production of 37.6+/-19.9%. Serum troponin-T levels as well as creatine phosphokinase were normal at baseline and remained unchanged. A transient rise of myoglobin after 1 h with a peak coronary sinus concentration after 2 h (101.5+/-39.0 microg/l) and peripheral venous concentration (90.5+/-32.5 microg/l) after 3 h (134.3% and 120.7%, respectively, of the upper normal limit, p<0.002) followed myocardial ischemia. In a control group of 20 patients without heart disease all variables remained unchanged. CONCLUSIONS:Severe short-lasting myocardial ischemia did not enhance troponin-T or creatine phoshokinase concentrations, whereas a transient slight cardiac release of myoglobin with a delay of 1 h and a coronary sinus peak concentration after 2 h was detected. This may be due to a rapid reperfusion effect on ischemic myocardium or minor damaged single myocardial cells.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Krüger D,Sheikhzadeh A,Stierle U,Simon R

doi

10.1016/j.ijcard.2003.12.010

subject

Has Abstract

pub_date

2005-02-15 00:00:00

pages

285-90

issue

2

eissn

0167-5273

issn

1874-1754

pii

S0167527304000701

journal_volume

98

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF CARDIOLOGY文献大全
  • Gender disparities in cardiovascular care access and delivery in India: Insights from the American College of Cardiology's PINNACLE India Quality Improvement Program (PIQIP).

    abstract：BACKGROUND:Limited data are available to assess whether access to and quality of cardiovascular disease (CVD) care are comparable among men and women in India. We analyzed data from the American College of Cardiology's PINNACLE (Practice Innovation and Clinical Excellence) India Quality Improvement Program (PIQIP) to e...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2016.04.058

    authors： Kalra A,Pokharel Y,Glusenkamp N,Wei J,Kerkar PG,Oetgen WJ,Virani SS,PINNACLE India Quality Improvement Program (PIQIP) Investigators.

    更新日期：2016-07-15 00:00:00

  • Comparative effectiveness and safety of apixaban, dabigatran, and rivaroxaban in patients with non-valvular atrial fibrillation.

    abstract：BACKGROUND:The comparative effectiveness and safety of individual direct oral anticoagulants (DOACs) in clinical practice is largely unknown. The study objectives were to compare effectiveness and safety of DOACs in patients with non-valvular atrial fibrillation (NVAF). METHODS:Based on nationwide registers we establi...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2018.03.047

    authors： Andersson NW,Svanström H,Lund M,Pasternak B,Melbye M

    更新日期：2018-10-01 00:00:00

  • Intra-aortic balloon counterpulsation: variations in use and complications.

    abstract：OBJECTIVE:To study variations in use of intra-aortic balloon counterpulsation (IABC) and their impact on complications by comparing aspects of its use in a Regional Cardiothoracic Centre with an international database. METHODS AND RESULTS:Indications, technique and complication rate in 764 consecutive patients treated...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2003.04.007

    authors： Azeem T,Stephens-Lloyd A,Spyt T,Hartshorne R,Gershlick AH

    更新日期：2004-04-01 00:00:00

  • Neutrophil-derived myeloperoxidase promotes atherogenesis and neointima formation in mice.

    abstract：BACKGROUND:Myeloperoxidase (MPO), expressed mainly in neutrophils, is an enzyme linked to inflammation and oxidative stress. MPO is an independent prognostic marker in healthy individuals as well as in patients with coronary artery disease. In this present study we analyze the role of MPO in experimental atherogenesis ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2015.11.128

    authors： Tiyerili V,Camara B,Becher MU,Schrickel JW,Lütjohann D,Mollenhauer M,Baldus S,Nickenig G,Andrié RP

    更新日期：2016-02-01 00:00:00

  • Distinct vascular and metabolic effects of different classes of anti-hypertensive drugs.

    abstract：BACKGROUND:ASCOT-BPLA study demonstrates that in hypertensive subjects, atenolol+bendroflumethiazide therapy is associated with higher incidence of adverse cardiovascular outcomes and developing diabetes than an amlodipine+perindopril regimen. This is not explained by changes in blood pressure alone. We hypothesized th...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ijcard.2008.11.017

    authors： Koh KK,Quon MJ,Han SH,Lee Y,Kim SJ,Koh Y,Shin EK

    更新日期：2010-04-01 00:00:00

  • Electrical storm is associated with impaired prognosis compared to ventricular tachyarrhythmias.

    abstract：BACKGROUND:Because data on electrical storm (ES) is limited, this study sought to compare the prognosis of patients with ES to those with ventricular tachyarrhythmias on mortality, rehospitalization and major adverse cardiac events (MACE). METHODS:In this retrospective study consecutive implantable cardioverter defibr...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2019.04.034

    authors： Behnes M,Müller J,Ellguth D,Schupp T,Taton G,Reiser L,Engelke N,Reichelt T,Bollow A,Kim SH,Barth C,Saleh A,Rusnak J,Weidner K,Nienaber CA,Mashayekhi K,Akin M,Bertsch T,Weiß C,Borggrefe M,Akin I

    更新日期：2019-10-01 00:00:00

  • Electrocardiographic measurement of infarct size compared to cardiac MRI in reperfused first time ST-segment elevation myocardial infarction.

    abstract：BACKGROUND:Myocardial infarct size (IS) following ST-segment elevation myocardial infarction (STEMI) is an important prognostic factor. We assessed the Selvester 32-point QRS score from the 12-lead ECG for measurement of IS in STEMI patients receiving reperfusion therapy compared to cardiac magnetic resonance imaging (...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2016.06.171

    authors： Holmes LE,Nguyen TL,Hee L,Otton J,Moses DA,French JK,Thomas L,Richards DA,Juergens CP

    更新日期：2016-10-01 00:00:00

  • The initial electrocardiogram pattern is a strong predictor of outcome in acute myocardial infarction.

    abstract：:We analyzed the significance of the initial electrocardiogram on the clinical outcome of 205 consecutive patients with a first myocardial infarction. Three different patterns of the electrocardiogram were defined: (A) Tall symmetric T waves in the involved leads; (B) ST segment elevation > 0.1 mV in two or more adjace...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(95)02436-z

    authors： García-Rubira JC,Pérez-Leal I,García-Martínez JT,Molano F,Hidalgo R,Gómez-Barrado JJ,Cruz JM

    更新日期：1995-10-01 00:00:00

  • Doppler echocardiographic evaluation of normal and thrombosed Björk-Shiley mitral prosthetic valves.

    abstract：:Doppler echocardiographic characteristics of 75 normally functioning Björk-Shiley mitral prostheses were studied in patients whose valvar function was considered normal by clinical and fluoroscopic evaluation. The mean Doppler peak and end-diastolic gradients were 9.01 +/- 3.23 mm Hg, and 2.36 +/- 1.0 mm Hg, respectiv...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(88)90293-8

    authors： Radhakrishnan S,Behl VK,Bajaj R,Bhatia ML,Shrivastava S

    更新日期：1988-09-01 00:00:00

  • Aortic valve surgery following previous coronary artery bypass grafting. Impact of calcification and leaflet movement.

    abstract：:We reviewed the reports of 27 patients who had an aortic valve replacement after previous coronary artery bypass grafting. The aortic valve disease -- mainly aortic stenosis -- showed a rapid rate of progression. In the time interval between coronary artery bypass grafting and aortic valve replacement of 4.6+/-2.2 yea...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/s0167-5273(98)00018-7

    authors： Eitz T,Kleikamp G,Minami K,Gleichmann U,Körfer R

    更新日期：1998-04-01 00:00:00

  • Inverse relation of haematocrit to cardiac index in mitral stenosis and atrial fibrillation.

    abstract：:We investigated the relationship between atrial fibrillation and the red cell parameters haematocrit, red cell concentration and mean corpuscular volume in 95 female patients with mitral stenosis (mean age 51+/-11 years, 38 patients in atrial fibrillation, 57 patients in sinus rhythm) who had undergone full blood exam...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/s0167-5273(99)00145-x

    authors： Peverill RE,Harper RW,Smolich JJ

    更新日期：1999-10-31 00:00:00

  • Cardiac fibrosis and vascular remodeling are attenuated by metformin in obese rats.

    abstract：BACKGROUND:Human obesity has been associated with alterations of vascular structure, especially in large and medium arteries, but the effects of insulin-sensitizers are not well known. METHODS:Twenty-five male Wistar rats received subcutaneous injections of monosodium glutamate (MSG) or an equivalent volume of vehicle...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2011.09.012

    authors： Burlá AK,Lobato NS,Fortes ZB,Oigman W,Neves MF

    更新日期：2013-05-25 00:00:00

  • Venticular expression of atrial and brain natriuretic peptides in patients with myocarditis.

    abstract：:We analyzed the ventricular expression of atrial and brain natriuretic peptides (ANP and BNP) in patients with myocarditis. Immunohistochemical analysis of endomyocardial biopsy specimens showed ANP and BNP immunoreactivity in the early myocarditis group (ANP in 4/10 and BNP in 3/10) and the late myocarditis group (AN...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(95)02468-9

    authors： Takemura G,Fujiwara H,Takatsu Y,Fujiwara T,Nakao K

    更新日期：1995-12-01 00:00:00

  • Predictors of permanent pacemaker requirement after transcatheter aortic valve implantation: insights from a Brazilian registry.

    abstract：BACKGROUND:The aim of this study is to evaluate the predictors of permanent pacemaker (PPM) implantation after TAVI. METHODS:Between January 2008 and February 2012, 418 patients with severe aortic stenosis underwent TAVI and were enrolled in a Brazilian multicenter registry. After excluding patients who died during th...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ijcard.2014.05.020

    authors： Gensas CS,Caixeta A,Siqueira D,Carvalho LA,Sarmento-Leite R,Mangione JA,Lemos PA,Colafranceschi AS,Caramori P,Ferreira MC,Abizaid A,Brito FS Jr,Brazilian Registry in Transcatheter Aortic Valve Implantation Investigators.

    更新日期：2014-08-01 00:00:00

  • The effect of configuration parameters of time-frequency maps in the detection of intra-QRS electrical transients of the signal-averaged electrocardiogram: impact in clinical diagnostic performance.

    abstract：:Time-frequency maps of signal-averaged electrocardiogram based on a short time Fourier transform (STFT) technique analysis was employed to assess the presence of high frequency electrical transients (turbulence) and arrhythmia risk assessment. The optimal configuration set of STFT variables aiming at risk stratificati...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2009.04.013

    authors： Benchimol-Barbosa PR,Nasario-Junior O,Nadal J

    更新日期：2010-11-05 00:00:00

  • Cannabis as a precipitant of cardiovascular emergencies.

    abstract：:Cannabis smoking is on the increase both in the United Kingdom and in the United States. For over three decades it has been known that cannabis has pathophysiological effects on the cardiovascular system, and previously an association with an increased risk of myocardial infarction has been reported. However, it is no...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2004.10.038

    authors： Lindsay AC,Foale RA,Warren O,Henry JA

    更新日期：2005-09-30 00:00:00

  • A predictive model for early mortality after surgical treatment of heart valve or prosthesis infective endocarditis. The EndoSCORE.

    abstract：BACKGROUND:The aim of this large retrospective study was to provide a logistic risk model along an additive score to predict early mortality after surgical treatment of patients with heart valve or prosthesis infective endocarditis (IE). METHODS:From 2000 to 2015, 2715 patients with native valve endocarditis (NVE) or ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ijcard.2017.03.148

    authors： Di Mauro M,Dato GMA,Barili F,Gelsomino S,Santè P,Corte AD,Carrozza A,Ratta ED,Cugola D,Galletti L,Devotini R,Casabona R,Santini F,Salsano A,Scrofani R,Antona C,Botta L,Russo C,Mancuso S,Rinaldi M,De Vincentiis C,

    更新日期：2017-08-15 00:00:00

  • Gain-of-function mutation in SCN5A causes ventricular arrhythmias and early onset atrial fibrillation.

    abstract：BACKGROUND:Mutations in SCN5A, the gene encoding the α-subunit of the cardiac sodium channel (NaV1.5), are associated with a broad spectrum of inherited cardiac arrhythmia disorders. The purpose of this study was to identify the genetic and functional determinants underlying a Dutch family that presented with a combine...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2017.01.113

    authors： Lieve KV,Verkerk AO,Podliesna S,van der Werf C,Tanck MW,Hofman N,van Bergen PF,Beekman L,Bezzina CR,Wilde AAM,Lodder EM

    更新日期：2017-06-01 00:00:00

  • Arterial pressure and aging.

    abstract：:Systolic arterial pressure increases with aging. This increase encompasses both the clinically normal and hypertensive ranges of pressure and is due in part to arterial stiffening. To what extent it may be modulated by life style changes that accompany aging is unknown. The stiffer arterial tree transmits the pulse wa...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/0167-5273(89)90097-1

    authors： Lakatta EG

    更新日期：1989-01-01 00:00:00

  • Aldosterone, atherosclerosis and vascular events in patients with stable coronary artery disease.

    abstract：BACKGROUND AND AIMS:Plasma aldosterone has been associated with all-cause and cardiovascular mortality in high-risk cardiovascular populations, including patients with heart failure, myocardial infarction and high-risk coronary artery disease (CAD) patients. In the present study, we evaluated the association of plasma ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2012.05.034

    authors： Hillaert MA,Lentjes EG,Kemperman H,van der Graaf Y,Nathoe HM,Beygui F,Montalescot G,Doevendans PA,Wassink AM,van Belle E,SMART Study Group.

    更新日期：2013-09-01 00:00:00

  • CCN2/CTGF attenuates myocardial hypertrophy and cardiac dysfunction upon chronic pressure-overload.

    abstract：BACKGROUND:Myocardial CCN2/CTGF (connective tissue growth factor) is strongly induced in heart failure (HF) and acts as a cardioprotective factor in ischemia/reperfusion injury. However, its functional role in myocardial hypertrophy remains unresolved. METHODS AND RESULTS:Transgenic mice with cardiac-restricted overex...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2013.01.165

    authors： Gravning J,Ahmed MS,von Lueder TG,Edvardsen T,Attramadal H

    更新日期：2013-10-03 00:00:00

  • Four years follow-up study in patients with Takayasu arteritis and severe aortic regurgitation; assessment by echocardiography.

    abstract：:We prospectively performed the follow-up study in 11 female patients with Takayasu arteritis and severe aortic regurgitation by echocardiography. A mean follow-up period was 4 years. The inflammatory state was controlled in all patients. Antihypertensive agents including beta-blocker were administered in nine patients...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/s0167-5273(96)88786-9

    authors： Hashimoto Y,Tanaka M,Hata A,Kakuta T,Maruyama Y,Numano F

    更新日期：1996-08-01 00:00:00

  • Evaluation of transient apical ballooning with cardiac magnetic resonance imaging and 31-phosphorous magnetic resonance spectroscopy.

    abstract：:Apical ballooning is an increasingly reported transient cardiomyopathy with yet unknown origin. In this study 2 cases of apical ballooning are described in whom we used a combined approach of cardiac magnetic resonance imaging (CMR) and 31-Phosphorous magnetic resonance spectroscopy (31P MRS). Electrocardiogram showed...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2006.06.060

    authors： Klug G,Wolf C,Trieb T,Frick M,Koehler A,Schocke MF,Jaschke W,Pachinger O,Metzler B

    更新日期：2007-05-31 00:00:00

  • Adherence to guidelines and mortality in atrial fibrillation.

    abstract：OBJECTIVE:Determining the adherence to ACC/AHA/ESC 2006 guidelines and its influence on the survival of patients with atrial fibrillation. METHODS:Prospective observational study of patients discharged during 2007 from an Internal Medicine department with a main or secondary diagnose of atrial fibrillation. The stroke...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2014.07.098

    authors： Díez-Manglano J,Gomes-Martín J,Al-Cheikh-Felices P,Pérez SI,Díez-Angulo R,Clemente-Sarasa C

    更新日期：2014-09-20 00:00:00

  • Diagnosis of recurrent rupture of interventricular septum during acute myocardial infarction by Doppler color flow mapping.

    abstract：:This report presents a 60-year-old female who had acute anteroseptal myocardial infarction and a grade 3/6 pansystolic murmur at left lower sternal border. Color Doppler echocardiographic examination revealed the presence of a ventricular septal defect which was later confirmed by contrast left ventriculography and at...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(91)90276-u

    authors： Fang BR,Chiang CW,Chang RP

    更新日期：1991-04-01 00:00:00

  • Prevalence of parameters of suboptimal scaffold deployment following angiographic guided bioresorbable vascular scaffold implantation in real world practice - an optical coherence tomography analysis.

    abstract：AIM:To assess the prevalence of suboptimal bioresorbable vascular scaffold (BVS, Abbott Vascular, Santa Clara, California) deployment in real world practice with intracoronary optical coherence tomography (OCT) imaging. METHODS:Consecutive patients who underwent percutaneous coronary intervention using BVS and the fin...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2016.06.096

    authors： Subban V,Sengottuvelu G,Uthayakumaran K,Rajendran R,Janakiraman E,Pakshirajan B,Thenpally JG,Kalidoss L,Victor SM,Kalarickal MS,Ajit MS

    更新日期：2016-10-01 00:00:00

  • Metabolic syndrome and insulin resistance are associated with abnormal left ventricular diastolic function and structure independent of blood pressure and fasting plasma glucose level.

    abstract：BACKGROUND:Abnormal left ventricular (LV) structure and diastolic function are frequently detected in a variety of heart diseases, and insulin resistance has been suggested to be associated with LV diastolic dysfunction (LVDD). The aims of this study were to determine the association between LVDD or LV structure and me...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ijcard.2011.02.039

    authors： Hwang YC,Jee JH,Kang M,Rhee EJ,Sung J,Lee MK

    更新日期：2012-08-23 00:00:00

  • Altered coronary endothelial function in a patient with asymptomatic left ventricular dysfunction.

    abstract：:Coronary endothelial dysfunction has been demonstrated in patients with symptomatic heart failure. Furthermore the endothelium has been implicated in the pathogensis of cardiomyopathy in patients with normal coronary angiograms and no other known causes of heart failure. Herein we describe an asymptomatic patient with...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(95)02513-8

    authors： Cannan CR,McGoon MD,Holmes DR Jr,Lerman A

    更新日期：1996-02-01 00:00:00

  • Anthracycline-induced cardiomyopathy: favourable effects of cardiac resynchronization therapy.

    abstract：:We report a case of severe refractory congestive heart failure after anthracycline chemotherapy in a patient with a narrow QRS interval on the electrocardiogram and echocardiographic evidence of left ventricular dyssynchrony, where cardiac resynchronization therapy resulted in normalization of left ventricular ejectio...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2008.11.194

    authors： Ahlehoff O,Galløe AM,Hansen PR

    更新日期：2010-07-09 00:00:00

  • Changes during exercise of ECG intervals related to increased risk for ventricular arrhythmia in repaired tetralogy of Fallot and their relationship to right ventricular size and function.

    abstract：PURPOSE:Our study aimed to assess pro-arrhythmogenic electrocardiographic changes during maximal physical exercise in patients operated for Tetralogy of Fallot (TOF). METHODS:TOF patients prospectively underwent: 1) bicycle ergometry, 2) cardiac MRI, and 3) 24-hour Holter. ECG data was analyzed at rest, at 60% of peak...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2007.02.009

    authors： van den Berg J,de Bie S,Meijboom FJ,Hop WC,Pattynama PM,Bogers AJ,Helbing WA

    更新日期：2008-03-14 00:00:00