Abstract：
BACKGROUND:Our previous findings revealed that increased oxidative stress, apoptosis and necrosis were implicated in acute fluoride (F-) induced cardiac dysfunction apart from hypocalcemia and hyperkalemia. Cardiac intermediate filaments (desmin and vimentin) and cytoskeleton linker molecule vinculin plays an imperative role in maintaining the architecture of cardiac cytoskeleton. In addition, AMPK is a stress activated kinase that regulates the energy homeostasis during stressed state. The present study was aimed to examine the role of cytoskeletal proteins and AMPK signaling molecules in acute F- induced cardiotoxicity in rats. METHODS:In order to study this, male Wistar rats were treated with single oral doses of 45 and 90mg/kgF- for 24h. RESULTS:Acute F- intoxicated rats showed declined cytoskeletal protein expression of desmin, vimentin and vinculin in a dose dependent manner compared to control. A significant increase in phosphorylation of AMPKα (Thr172), AMPKß1 (Ser108) and Acetyl-coA carboxylase (ACC) (Ser79) in the myocardium and associated ATP deprivation were found in acute F- intoxicated rats. Further, ultra-structural studies confirmed myofibril lysis with interruption of Z lines, dilated sarcoplasmic reticulum and damaged mitochondrion were observed in both the groups of F- intoxicated rats. CONCLUSION:Taken together, these findings reveal that acute F- exposure causes sudden heart failure by altering the expression of cytoskeletal proteins and AMPK signaling molecules.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Panneerselvam L,Raghunath A,Perumal Edoi
10.1016/j.ijcard.2016.11.221subject
Has Abstractpub_date
2017-02-15 00:00:00pages
96-101eissn
0167-5273issn
1874-1754pii
S0167-5273(16)32094-0journal_volume
229pub_type
杂志文章abstract：BACKGROUND:Aortic stenosis (AS) is an active disease, but the determinants of AS progression remain largely unknown. Low levels of Fetuin-A, a powerful inhibitor of ectopic calcification, have been linked to ectopic calcium tissue deposition but its role in AS progression has not been clearly evaluated. METHODS:In our...
journal_title：International journal of cardiology
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journal_title：International journal of cardiology
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：International journal of cardiology
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journal_title：International journal of cardiology
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journal_title：International journal of cardiology
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pub_type： 临床试验,信件,随机对照试验
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pub_type： 杂志文章
doi：10.1016/s0167-5273(01)00626-x
更新日期：2002-03-01 00:00:00
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journal_title：International journal of cardiology
pub_type： 杂志文章
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journal_title：International journal of cardiology
pub_type： 杂志文章
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journal_title：International journal of cardiology
pub_type： 杂志文章
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journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2009.03.054
更新日期：2010-09-03 00:00:00
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journal_title：International journal of cardiology
pub_type： 信件
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更新日期：2011-05-19 00:00:00
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pub_type： 信件
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journal_title：International journal of cardiology
pub_type： 杂志文章
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pub_type： 杂志文章
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