Abstract:
:This study was designed to investigate the effect of sarpogrelate hydrochloride on impaired endothelium-dependent relaxation (EDR) induced by high glucose in isolated rat aorta. Both acetylcholine-induced EDR and sodium nitroprusside-induced endothelium-independent relaxation (EIR) were measured after the rings were exposed to high glucose in the absence and presence of sarpogrelate hydrochloride. Co-incubation of aortic rings with high glucose for 24h resulted in a significant inhibition of EDR, but had no effects on EIR. After incubation of the rings in the co-presence of sarpogrelate hydrochloride with high glucose for 24h, sarpogrelate hydrochloride significantly attenuated impaired EDR. This protective effect of sarpogrelate hydrochloride was abolished by N(G)-nitro-L-arginine methyl ester. Sarpogrelate hydrochloride significantly decreased superoxide anion (O(2)(-)) production and increased superoxide dismutase (SOD) activity and the nitric oxide (NO) release. These results suggest that sarpogrelate hydrochloride can restore impaired EDR induced by high glucose in isolated rat aorta, which may be related to scavenging oxygen free radicals and enhancing NO production.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Sun YM,Su Y,Jin HB,Li J,Bi Sdoi
10.1016/j.ijcard.2009.09.539subject
Has Abstractpub_date
2011-03-17 00:00:00pages
383-7issue
3eissn
0167-5273issn
1874-1754pii
S0167-5273(09)01482-Xjournal_volume
147pub_type
杂志文章abstract:BACKGROUND:The management of heart disease in pregnancy is highly specialized. Guidelines are based on observational studies. This paper describes our experience of these patients, including adverse cardiac events, adherence to guidelines, and areas of suboptimal management. METHODS:Patients referred to the service be...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2007.11.084
更新日期:2009-03-20 00:00:00
abstract:AIMS:To better understand relationship between histological medial degenerative changes (MDC), pathological status [thoracic aorta aneurysm (TAA), thoracic aorta dissection (TAD), bicuspid aortic valve (BAV), and non-BAV] and aortic size at imaging. METHODS AND RESULTS:We collected 496 ascending aorta surgical specime...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2020.04.011
更新日期:2020-07-15 00:00:00
abstract:BACKGROUND:The role of serum uric acid (SUA) as a risk factor for cardiovascular disease (CVD) remains controversial. Little is known about its predictive value for mortality from congestive heart failure (CHF) and stroke, particularly in elderly, post-menopausal women. METHODS:The relation of SUA to risk of death fro...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2007.11.094
更新日期:2008-04-10 00:00:00
abstract::We examined serial changes in serum levels of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) measured by ELISAs in 45 patients with acute myocardial infarction (AMI) who received heparin intravenously for 3 to 5 days after the onset and in 30 control subjects with an old myocardial...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(98)00251-4
更新日期:1998-11-30 00:00:00
abstract::An anatomical study of 34 specimens presenting with tricuspid atresia, in which particular emphasis was devoted to the atrioventricular junctional area, revealed 5 cases with an imperforate valve. In 1 heart the valve was completely committed to the right ventricle. In the other 4, however, the membrane was related no...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(84)90006-8
更新日期:1984-11-01 00:00:00
abstract:BACKGROUND:Little is known if the levels of physical activity required for the prevention of incident heart failure (HF) and other cardiovascular events vary in community-dwelling older adults. METHODS:We studied 5503 Cardiovascular Health Study (CHS) participants, age ≥ 65 years, free of baseline HF. Weekly metabolic...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2012.12.053
更新日期:2013-10-03 00:00:00
abstract:BACKGROUND:Progressive thinning and dilation of the LV due to ischemic heart failure (IHF) increases wall stress and myocardial oxygen consumption. Injectable biopolymers implanted in the myocardial wall have been used to increase wall thickness to reduce chamber volume, decrease wall stress, and improve cardiac functi...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.09.179
更新日期:2018-03-15 00:00:00
abstract:BACKGROUND:The aim of the study was to report the impact of our hypothermia protocol on survival and neurological outcome. Furthermore, we were interested in the risk of bleeding complications in patients with acute myocardial infarction (AMI) being treated with percutaneous coronary revascularisation (PCI) and therape...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2007.12.008
更新日期:2009-03-06 00:00:00
abstract:BACKGROUND:Exome sequencing is an established strategy to identify causal variants in families with two or more members affected by congenital heart disease (CHD). This unbiased approach, in which both rare and common variants are identified, makes it suitable to research complex, heterogeneous diseases such as CHD. M...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.12.024
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:To clarify the influence of hemoglobin concentration and platelet count on adverse outcomes of Japanese patients with non-valvular atrial fibrillation (NVAF), a post hoc analysis of the J-RHYTHM Registry was performed. METHODS:A consecutive series of outpatients with atrial fibrillation were enrolled from 1...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2019.11.127
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:In general, women have lower risk for cardiovascular disease. We tested whether this sex-specific protection persists also in the presence of hypertensive left ventricular hypertrophy (LVH). METHODS:12,329 women and men with hypertension and free from prevalent cardiovascular disease enrolled in the prospec...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.12.086
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Abnormal left ventricular (LV) structure and diastolic function are frequently detected in a variety of heart diseases, and insulin resistance has been suggested to be associated with LV diastolic dysfunction (LVDD). The aims of this study were to determine the association between LVDD or LV structure and me...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2011.02.039
更新日期:2012-08-23 00:00:00
abstract:BACKGROUND:Angiotensin receptor antagonists (ARBs) improve outcomes in patients with heart failure (HF) with reduced left ventricular ejection fraction, but may induce hyperkalemia (HK) and/or a worsening of renal function (WRF). METHODS AND RESULTS:The incidence and risk factors of HK and its inter-relationship with ...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ijcard.2014.02.034
更新日期:2014-05-15 00:00:00
abstract::We report on a case of acute non-cardiogenic negative-pressure pulmonary edema developed during an ablation procedure of an accessory pathway in a patient with no structural heart disease. That potentially serious complication has not been previously reported during an interventional cardiology procedure. ...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2009.04.038
更新日期:2009-11-12 00:00:00
abstract:AIM:To determine whether right atrial (RA) function has prognostic value in patients with idiopathic pulmonary arterial hypertension (PAH). METHODS AND RESULTS:Overall, 104 patients (70 female, mean age 58±13years) with idiopathic PAH underwent standard Doppler echocardiography and strain and strain rate (SR) analysis...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.08.047
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:CSR-CSA is frequent in patients with CHF. Dilated cardiomyopathy (DCM) is a structural heart disease with strong genetic background, yet one of the leading etiological causes of CHF. Studies have showed that the HSPB7 gene is associated with DCM. OBJECTIVES:We aimed to explore the prevalence of polymorphism...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.07.107
更新日期:2016-10-15 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the prognostic value of myocardial focal fibrosis quantified by late gadolinium enhanced (LGE) magnetic resonance imaging (MRI) in patients with heart failure with preserved ejection fraction (HFpEF). METHODS:One-hundred eleven HFpEF patients (mean age: 70 ± 14 years...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2015.05.048
更新日期:2015-07-15 00:00:00
abstract::Clear guidelines are lacking for the management of the clinical pattern of first-episode type atrial fibrillation (AF). We retrospectively analysed the clinical evolution of patients with self-limited first episode AF identified from among from 200 patients who had been hospitalised in our cardiology ward with AF. Of ...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2006.08.090
更新日期:2007-10-01 00:00:00
abstract::A case of severe valvar pulmonary stenosis in a 60-year-old woman is described. Percutaneous balloon valvoplasty was performed without complication and reduced the right ventricular outflow pressure gradient from 95 mm Hg to 25 mm Hg. Balloon valvoplasty is an effective alternative to surgical valvotomy in adults as w...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(86)90184-1
更新日期:1986-05-01 00:00:00
abstract::Common arterial trunk is a rare congenital anomaly, usually found in the setting of a concordant atrioventricular connexion. The association of a common arterial trunk with absence of the right atrioventricular connexion is very rare, having, as far as we know, been reported only twice in the literature. In the case r...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(90)90298-j
更新日期:1990-06-01 00:00:00
abstract:BACKGROUND:The risk of adverse events in patients with left ventricular non-compaction cardiomyopathy (LVNC) is substantial. This study was designed to determine the prognostic value of NT-proBNP, left ventricular ejection fraction (LVEF), NYHA class, and exercise capacity in LVNC patients. METHODS:Cox regression anal...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.02.064
更新日期:2017-06-01 00:00:00
abstract::This study was performed to evaluate whether transoesophageal atrial pacing could also stop ventricular tachycardias with low rates and no haemodynamic impairment. Prior to resorting to ventricular endocardial pacing, seven male patients, aged between 15 and 73 years, were treated by transoesophageal atrial pacing for...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(90)90318-y
更新日期:1990-09-01 00:00:00
abstract:BACKGROUND:Several studies have reported that hepatitis B virus (HBV) infection affects the risk of coronary heart disease. However, its association is controversial. Thus, we conducted a systematic review and meta-analysis to better understand it. METHODS:Relevant studies published before October 2017 were identified...
journal_title:International journal of cardiology
pub_type: 杂志文章,meta分析
doi:10.1016/j.ijcard.2018.04.059
更新日期:2018-08-15 00:00:00
abstract:BACKGROUND:We previously investigated the prognostic utility of red blood cell (RBC) n-3 fatty acids (FAs) in survivors of an acute myocardial syndrome (ACS) but found no relationship with all-cause mortality and cardiac death or MI after two years. Here we extend our follow-up to 7years, focusing on the potential pred...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.09.202
更新日期:2017-12-15 00:00:00
abstract::The effects of disopyramide on the atrial fibrillation threshold (AFT) in the human atrium were investigated. To evaluate atrial vulnerability, the following electrophysiologic parameters were measured before and after the administration of disopyramide (2 mg/kg) in 12 patients with paroxysmal atrial fibrillation: The...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
doi:10.1016/0167-5273(95)02467-b
更新日期:1995-11-24 00:00:00
abstract:BACKGROUND:Syncope has been associated with increased risk of sudden cardiac arrest (SCA) in specific patient populations, such as hypertrophic cardiomyopathy, heart failure, and long QT syndrome, but data are lacking on the risk of SCA associated with syncope among patients with coronary artery disease (CAD), the most...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2016.12.021
更新日期:2017-03-15 00:00:00
abstract::The relationship between transoesophageal Doppler pulmonary venous flow pattern and spontaneous left atrial contrast was studied in 23 patients with isolated severe mitral stenosis (mitral valve area = 0.8 +/- 0.2 cm2). The patients with none or minimal (1+) spontaneous contrast (n = 15, group I) were compared with th...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(92)90307-o
更新日期:1992-09-01 00:00:00
abstract::The Ross procedure has been considered in children as an optimal surgical procedure due to potential growth of the aortic annulus, lack of anticoagulation requirement, very low morbidity rate and excellent survival. Five-hundred-thirty-six (366 male, mean age 29.4 ± 11.1 years) underwent Ross procedure between 1990 an...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2020.07.009
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Detection of pulmonary vasoreactivity is important for the evaluation of patient with pulmonary arterial hypertension (PAH). The present study aimed to investigate the acute hemodynamic responses to adenosine and iloprost in patients with congenital heart defects (CHDs) and severe PAH. PATIENTS AND METHODS:...
journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijcard.2010.04.093
更新日期:2011-03-17 00:00:00
abstract:BACKGROUND:Handgrip strength (HGS) and gait speed (GS) are objective components of the frailty syndrome in the elderly, and are associated with increased all-cause mortality. However, their association with cardiovascular (CVD) mortality is less lucid. The present systematic review aims to summarize the available liter...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2016.04.068
更新日期:2016-07-15 00:00:00