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Prognostic power of NT-proBNP in left ventricular non-compaction cardiomyopathy.

Abstract：

BACKGROUND:The risk of adverse events in patients with left ventricular non-compaction cardiomyopathy (LVNC) is substantial. This study was designed to determine the prognostic value of NT-proBNP, left ventricular ejection fraction (LVEF), NYHA class, and exercise capacity in LVNC patients. METHODS:Cox regression analyses were performed for evaluating the prognostic value of NT-proBNP, LVEF, NYHA class, and exercise capacity on the occurrence of death or heart transplantation. 153 patients were included. RESULTS:During 1013 person-years (longest follow-up 18.5years) 23 patients (15%) died or underwent heart transplantation. We observed a significant relationship of NT-proBNP (adjusted HR 2.44, 95% CI 1.45-4.09, for every NT-proBNP doubling, p=0.0007) and LVEF (adjusted HR for age 60years: 2.68, 95% CI 1.62-4.41, p=0.0001) with the risk of death or heart transplantation. Combined covariate analysis indicated a strong influence of NT-proBNP (adjusted 2.89, 95% CI 1.33-6.26, p=0.007), whereas LVEF was no longer significant (adjusted HR 0.82, 95% CI 0.42-1.67, p=0.66) demonstrating a favorable prognostic power of NT-proBNP over LVEF. An increase in NYHA class was associated with a worse outcome, and exercise capacity revealed a trend in the same direction. For all the abovementioned analyses, similar results were obtained when assessing the values at first presentation. CONCLUSION:This study provides evidence that an increase in NT-proBNP is a strong predictor of outcome in patients with LVNC. The prognostic power of NT-proBNP is at least as good as that of LVEF, indicating that routine NT-proBNP measurement may improve risk assessment in LVNC.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Stämpfli SF,Erhart L,Hagenbuch N,Stähli BE,Gruner C,Greutmann M,Niemann M,Kaufmann BA,Jenni R,Held L,Tanner FC

doi

10.1016/j.ijcard.2017.02.064

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

321-327

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(16)32865-0

journal_volume

236

pub_type

杂志文章

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