Abstract:
BACKGROUND:The components of CHADS2 score were reported to be important risk factors for the development of atrial fibrillation (AF). The goal of the current study was to investigate whether the CHADS2 score was a useful scheme in predicting new-onset AF. Furthermore, we aimed to use the CHADS2 scoring system to estimate the individual risk in developing AF for patients with different comorbidities. METHODS:From January 1, 2000 to December 31, 2001, a total of 702,502 patients older than 18 years old and who had no history of cardiac arrhythmias were identified from the "National Health Insurance Research Database" released by the Taiwan National Health Research Institutes. The CHADS2 score was calculated for every patient. Finally, 628,807 (score 0), 47,039 (score 1), 15,655 (score 2), 6843 (score 3), 3315 (score 4), 790 (score 5) and 53 (score 6) patients were studied and followed for the occurrences of AF. RESULTS:During a follow-up of 9.0 ± 2.2 years, there were 9187 (1.3%) patients experiencing new-onset AF. The incidence of AF was 1.5 per 1000 patient-years. The incidence increased from 0.8 per 1000 patient-years for patients with a CHADS2 score of 0 to 34.6 per 1000 patient-years for those with a CHADS2 score of 6. After an adjustment for the gender and comorbidities, the hazard ratio (95% confidence interval) of each increment of the CHADS2 score in predicting AF was 2.342 (2.309-2.375; p<0.001). CONCLUSIONS:The CHADS2 score, consisting of an age >75 and several clinical risk factors was useful in risk estimation and stratification of new-onset AF.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Chao TF,Liu CJ,Chen SJ,Wang KL,Lin YJ,Chang SL,Lo LW,Hu YF,Tuan TC,Wu TJ,Chen TJ,Chen SAdoi
10.1016/j.ijcard.2012.12.011subject
Has Abstractpub_date
2013-09-30 00:00:00pages
1360-3issue
2eissn
0167-5273issn
1874-1754pii
S0167-5273(12)01639-7journal_volume
168pub_type
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