当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF CARDIOLOGY期刊下所有文献 > Impaired baroreflex as a cause of chronotropic incompetence during exercise via autonomic mechanism in patients with heart disease.

Impaired baroreflex as a cause of chronotropic incompetence during exercise via autonomic mechanism in patients with heart disease.

Abstract：

PURPOSE:It is thought that the mechanisms responsible for impaired chronotropic response to exercise are related to disturbance of cardiovascular autonomic regulation such as the baroreflex. However, it is still unclear whether the baroreflex mechanisms modulate heart rate (HR) responses to exercise via vagal and/or sympathetic alteration. We therefore investigated the effects of baroreflex sensitivity (BRS) on the exercise HR response in the early phase of vagal deactivation and in the later phase of sympathetic excitation via metabolic stimulation. METHODS:Twenty-four patients (18 males and 6 females, age 59+/-9 years) with heart disease underwent symptom-limited treadmill exercise testing according to the Bruce protocol, and BRS was measured utilizing the phenylephrine method. Subjects were grouped by their resting BRS value: 12 with normal BRS (> or =6 ms/mmHg) and 12 with depressed BRS (<6 ms/mmHg). The HR response to exercise was assessed using two parameters: the increment in HR during exercise and the ratio of HR response to the metabolic reserve (chronotropic index). RESULTS:(1) In the patients with depressed BRS, the HR responses within 1 min after the start of exercise and from 1 min to peak exercise were attenuated compared with those having a normal BRS (15+/-8 vs. 24+/-8 bpm and 36+/-9 vs. 47+/-15 bpm, respectively). (2) The chronotropic index in the patients with depressed BRS was lower than in those with normal BRS (0.50+/-0.14 vs. 0.64+/-0.08). CONCLUSION:These findings suggest that impaired BRS modulates both the parasympathetic influence in early exercise and sympathetic effects in the later phase on HR response to exercise.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Fukuma N,Oikawa K,Aisu N,Kato K,Kimura-Kato YK,Tuchida T,Mabuchi K,Takano T

doi

10.1016/j.ijcard.2003.12.007

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

503-8

issue

3

eissn

0167-5273

issn

1874-1754

pii

S0167527304000543

journal_volume

97

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF CARDIOLOGY文献大全
  • Acute myocardial infarction in the young - National Trend Analysis with gender-based difference in outcomes.

    abstract：INTRODUCTION:Although acute myocardial infarction (AMI) is a disease predominantly affecting adults >60 years of age, a significant proportion of the young population who have different risk profiles, are also affected. We undertook a retrospective analysis using National Inpatient Sample (NIS) 2010 to 2014 to evaluate...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2019.11.096

    authors： Bandyopadhyay D,Chakraborty S,Amgai B,Patel N,Hajra A,Heise L,Sud K,Ghosh RK,Herzog E,Aronow WS,Fonarow GC,Lavie CJ

    更新日期：2020-02-15 00:00:00

  • Rethinking cardiac resynchronization therapy: the impact of ventricular dyssynchrony on outcome.

    abstract：OBJECTIVE:To analyze whether left ventricular dyssynchrony (LVD) at baseline is predictive for long-term outcome in heart failure (CHF) patients with left ventricular (LV) dysfunction and conduction disturbances treated with cardiac resynchronization therapy (CRT). METHODS:In 535 consecutive individuals with CHF sched...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2013.06.060

    authors： Prinz C,Felice CD,Lehmann R,Schwarz M,Prinz EM,Bitter T,Vogt J,Lamp B,Faber L,Horstkotte D

    更新日期：2013-10-09 00:00:00

  • Captopril cardioplegia on myocardial protection in the hypertrophied rat hearts.

    abstract：:Hearts with pressure-overload hypertrophy show an increased intracardiac activation of the renin-angiotensin system (RAS) which may contribute to myocardial ischemia and reperfusion injury. This study investigates whether the hypertrophied myocardium is more vulnerable to ischemia and reperfusion injury and whether th...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(94)90179-1

    authors： Zhang YH,Xu SC

    更新日期：1994-12-01 00:00:00

  • Differences in inflammatory and thrombotic markers between unstable angina and acute myocardial infarction.

    abstract：BACKGROUND:Unstable coronary syndromes are characterised by increased inflammatory process and endothelial activation. However, the underlying mechanisms of the acute coronary syndromes are still obscure. We evaluated the differences of inflammatory and thrombotic markers, at the acute phase of unstable angina (UA) and...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2006.03.011

    authors： Tousoulis D,Antoniades C,Bosinakou E,Kotsopoulou M,Tsoufis C,Marinou K,Charakida M,Stefanadi E,Vavuranakis M,Latsios G,Stefanadis C

    更新日期：2007-02-07 00:00:00

  • Biventricular pacemaker implantation in a patient with isolated noncompaction of the right ventricular myocardium.

    abstract：:Isolated noncompaction of the ventricular myocardium is an unclassified cardiomyopathy and is thought to be due to arrest of myocardial morphogenesis. Fetal arrhythmias may occur in approximately half of the patients and account for the death in this disorder. We describe a patient with isolated noncompaction of the r...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2007.07.037

    authors： Ying ZQ,Ma J,Chen S,Xu G,Chen MY,You XD

    更新日期：2008-12-17 00:00:00

  • Predictors of response to cardiac resynchronization therapy: A systematic review.

    abstract：BACKGROUND:Multiple studies have sought to determine variables associated with improved "response" to cardiac resynchronization therapy(CRT). Such variables, however, are often derived from inadequately controlled, single center cohort studies calling external validity into question. We sought to determine predictors o...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijcard.2016.09.078

    authors： Rickard J,Michtalik H,Sharma R,Berger Z,Iyoha E,Green AR,Haq N,Robinson KA

    更新日期：2016-12-15 00:00:00

  • The impact of a 21-day ultra-endurance ride on the heart in young, adult and older adult recreational cyclists.

    abstract：BACKGROUND:This study assessed the acute effect of 21 days of challenging exercise on heart structure and function in recreationally active people across a range of age categories. METHODS:15 recreationally active people completed a 21-day fundraising cycling ride (MADRIDE) over a distance of 3515 km. Twenty-four hour...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2019.03.016

    authors： Wundersitz D,Williamson J,Nadurata V,Nolan K,Lavie C,Kingsley M

    更新日期：2019-07-01 00:00:00

  • Effect of exercise training on skeletal muscle fibre characteristics in men with chronic heart failure. Correlation between skeletal muscle alterations, cytokines and exercise capacity.

    abstract：BACKGROUND:In patients with congestive heart failure (CHF) there is a shift from aerobic type I muscle fibres to less aerobic type II fibres. Exercise training has been shown to have beneficial effects on exercise performance, peripheral pathology and the neurohumoral profile in stable patients with CHF. This study eva...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/s0167-5273(02)00014-1

    authors： Larsen AI,Lindal S,Aukrust P,Toft I,Aarsland T,Dickstein K

    更新日期：2002-04-01 00:00:00

  • Continuation of hormone replacement therapy during acute myocardial infarction after the women's health initiative study. Is it the time for change?

    abstract：:Hormone replacement therapy (HRT) was given for many years in order to relieve menopausal symptoms and was used for as long as symptom control was necessary. The Heart and Estrogen/Progestin Replacement Study (HERS) and Women's Health Initiative (WHI) studies showed that HRT should not be given for primary or secondar...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijcard.2005.04.002

    authors： Yosefy C,Feingold M

    更新日期：2006-03-08 00:00:00

  • Clinical outcome of patients undergoing multivessel coronary stent implantation.

    abstract：OBJECTIVES:To evaluate the outcome of patients undergoing multivessel coronary stent implantation. BACKGROUND:Percutaneous transluminal coronary angioplasty has been shown to be an effective treatment for multivessel coronary artery disease, although the need for repeat revascularization continues to be a limitation. ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/s0167-5273(97)00333-1

    authors： Mathew V,Rihal CS,Berger PB,Bell MR,Garratt KN,Holmes R Jr

    更新日期：1998-03-13 00:00:00

  • Remodeling in acute coronary syndromes: expectations and frustrations for risk assessment and therapy.

    abstract：:Matrix metalloproteinases are involved in the development of acute coronary syndromes, but they are not reliable clinical markers of the occurrence or the outcome of this syndrome. Many limitations in their assessment account for such failure. Functional genetic polymorphisms, as alternatives to plasma levels, might b...

    journal_title：International journal of cardiology

    pub_type： 评论,信件

    doi：10.1016/j.ijcard.2008.04.005

    authors： Fiotti N,Altamura N,Giansante C

    更新日期：2009-05-29 00:00:00

  • Is it safe to use TNF-α blockers for systemic inflammatory disease in patients with heart failure? Importance of dosage and receptor specificity.

    abstract：:Tumor necrosis factor-alpha (TNF-α) blockers are widely used in the treatment of chronic inflammatory diseases, especially chronic arthritis. Current guidelines advise against the use of such agents in patients who have a concomitant heart failure. Consequently, a group of patients with a devastating inflammatory dise...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijcard.2012.11.112

    authors： Diamantopoulos AP,Larsen AI,Omdal R

    更新日期：2013-09-01 00:00:00

  • Heart failure decreases passive tension generation of rat diaphragm fibers.

    abstract：BACKGROUND:Diaphragm dysfunction is well-known to limit quality of life and prognosis of patients with heart failure (HF), but its underlying mechanisms are not well understood. In an animal model for HF we recently showed that impaired diaphragm contractility arises at the single fiber level and is associated with sar...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2008.12.042

    authors： van Hees HW,Ottenheijm CA,Granzier HL,Dekhuijzen PN,Heunks LM

    更新日期：2010-06-11 00:00:00

  • Isoproterenol enhancement of I(Ks) current in amiodarone-induced long QT syndrome.

    abstract：:The response over time of the QT interval and the Transmural Dispersion of Repolarization (TDR) to Isoproterenol infusion (ISO) in an 85 year-old-man with severe and syntomatic bradycardia, in the setting of an Amiodarone-induced Long QT Syndrome (LQTS) is the subject of this communication. ISO shortened the QT and de...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2007.07.175

    authors： Raviña T,Raviña M,Gutierrez J

    更新日期：2009-04-17 00:00:00

  • Early effects of kidney transplantation on the heart - A cardiac magnetic resonance multi-parametric study.

    abstract：:Increased native myocardial T1 times in chronic kidney disease (CKD) may be due to diffuse interstitial myocardial fibrosis (DIF) or due to interstitial edema/inflammation. Concerns relating to nephrogenic systemic fibrosis with gadolinium-based contrast agents (GBCA) limit their use in end-stage kidney disease (ESKD)...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2019.06.007

    authors： Hayer MK,Radhakrishnan A,Price AM,Baig S,Liu B,Ferro CJ,Captur G,Townend JN,Moon JC,Edwards NC,Steeds RP

    更新日期：2019-10-15 00:00:00

  • Early repolarization of surface ECG predicts fatal ventricular arrhythmias in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy and symptomatic ventricular arrhythmias.

    abstract：BACKGROUND:The clinical characteristics and prognostic value of early repolarization (ER) in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) and symptomatic ventricular arrhythmias remain unclear. We investigated the prevalence, clinical features, and cardiovascular outcomes of patients...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2015.06.007

    authors： Chan CS,Lin YJ,Chang SL,Lo LW,Hu YF,Chao TF,Chung FP,Liao JN,Chen YJ,Chen SA

    更新日期：2015-10-15 00:00:00

  • Effects of amlodipine and lacidipine on heart rate variability in hypertensive patients with stable angina pectoris and isolated left ventricular diastolic dysfunction.

    abstract：OBJECTIVE:To estimate the influence of therapy with amlodipine (A) or lacidipine (L) on heart rate variability (HRV) time and frequency domain parameters in hypertensive patients with stable angina pectoris and isolated left ventricular diastolic dysfunction. METHODS:After a 1-week washout period, the patients were ra...

    journal_title：International journal of cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.ijcard.2004.03.040

    authors： Zaliūnas R,Brazdzionyte J,Zabiela V,Jurkevicius R

    更新日期：2005-06-08 00:00:00

  • Low socioeconomic status of a patient's residential area is associated with worse prognosis after acute myocardial infarction in Sweden.

    abstract：INTRODUCTION:Previous studies have established a relationship between socioeconomic status (SES) and survival in coronary heart disease. Acute cardiac care in Sweden is considered to be excellent and independent of SES. We studied the influence of area-level socioeconomic status on mortality after hospitalization for a...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2014.12.060

    authors： Bergström G,Redfors B,Angerås O,Dworeck C,Shao Y,Haraldsson I,Petursson P,Milicic D,Wedel H,Albertsson P,Råmunddal T,Rosengren A,Omerovic E

    更新日期：2015-03-01 00:00:00

  • Use of aspirin in conjunction with angiotensin-converting enzyme inhibitors does not worsen long-term survival in heart failure.

    abstract：BACKGROUND:A negative interaction has been shown to exist between aspirin and angiotensin-converting enzyme inhibitors (ACE-I) in subjects with heart failure. We explored the effect of combined ACE-I and aspirin therapy compared to ACE-I without aspirin on clinical outcomes in patients with heart failure. METHODS:430 ...

    journal_title：International journal of cardiology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0167-5273(02)00401-1

    authors： Harjai KJ,Solis S,Prasad A,Loupe J

    更新日期：2003-04-01 00:00:00

  • Changes in body surface potential distributions induced by isoproterenol and Na channel blockers in patients with the Brugada syndrome.

    abstract：BACKGROUND:The characteristics of unique ECG findings in the Brugada syndrome have not been well explained. METHODS:To clarify their characteristics and mechanisms, body surface maps (BSM) were recorded from patients with the Brugada syndrome (13 cases; a mean age of 48 years) before and after administration of isopro...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2003.05.025

    authors： Izumida N,Asano Y,Doi S,Wakimoto H,Fukamizu S,Kimura T,Ueyama T,Sakurada H,Kawano S,Sawanobori T,Hiraoka M

    更新日期：2004-06-01 00:00:00

  • Isolated ventricular noncompaction mimicking arrhythmogenic right ventricular cardiomyopathy--a study of nine patients.

    abstract：BACKGROUND:Isolated ventricular noncompaction is considered to predominantly affect the left ventricle. It is characterized by increased left ventricular wall thickness and deep intertrabecular recesses with to-and-fro blood flow that remains in continuity with the ventricular flow. Aim of the study was to present a gr...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2009.05.062

    authors： Wlodarska EK,Wozniak O,Konka M,Piotrowska-Kownacka D,Walczak E,Hoffman P

    更新日期：2010-11-05 00:00:00

  • The predictive value of C-reactive protein on recurrence of atrial fibrillation after cardioversion with or without treatment with atorvastatin.

    abstract：BACKGROUND:The aim of this study was to investigate whether high-sensitivity C-reactive protein (hsCRP) levels prior to cardioversion (CV) predict recurrence of atrial fibrillation (AF) in patients randomized to treatment with either atorvastatin or placebo 30 and 180 days after CV. METHODS:This was a prespecified sub...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ijcard.2012.05.071

    authors： Höglund N,Andersson J,Almroth H,Tornvall P,Englund A,Rosenqvist M,Jensen SM,Boman K

    更新日期：2013-09-01 00:00:00

  • Circulating procoagulant microparticles in acute pulmonary embolism: a case-control study.

    abstract：:We investigated whether circulating procoagulant microparticles (CPMPs) contributed to hypercoagulability in 45 patients with acute pulmonary embolism (APE) and in 45 controls with and 45 controls without cardiovascular risk factors. Concentrations of CPMPs and platelet-derived microparticles (PMPs) were statistically...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2009.11.048

    authors： Bal L,Ederhy S,Di Angelantonio E,Toti F,Zobairi F,Dufaitre G,Meuleman C,Mallat Z,Boccara F,Tedgui A,Freyssinet JM,Cohen A

    更新日期：2010-11-19 00:00:00

  • Pseudoaneurysm of the left ventricle with moderate left-to-right shunt.

    abstract：:A 79 year old man was admitted to the hospital with increased breathlessness and fatigue on minimal exertion, and this since a few weeks. Transthoracic and transesophageal echocardiography, followed by cardiovascular magnetic resonance imaging, demonstrated a cardiac pseudoaneurysm connected with both ventricular cavi...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2007.07.169

    authors： Schreurs M,Herregods MC,Bogaert J,Troost E,Budts W

    更新日期：2008-10-30 00:00:00

  • Strategies for the prevention of acute mountain sickness and treatment for large groups making a rapid ascent in China.

    abstract：:Approximately 26.8% of China's land area has an elevation of 3000 m above sea level or higher. Because of recent demands for economic development and new construction in highland areas, many people have relocated from the plains to high plateau regions and have to face the possibility of contracting acute mountain sic...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijcard.2013.08.059

    authors： Luo Y,Yang X,Gao Y

    更新日期：2013-10-30 00:00:00

  • Hypertension in pregnancy and risk of coronary heart disease and stroke: A prospective study in a large UK cohort.

    abstract：BACKGROUND:Many studies investigating long-term vascular disease risk associated with hypertensive pregnancies examined risks in relatively young women among whom vascular disease is uncommon. We examined the prospective relation between a history of hypertension during pregnancy and coronary heart disease (CHD) and st...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2016.07.170

    authors： Canoy D,Cairns BJ,Balkwill A,Wright FL,Khalil A,Beral V,Green J,Reeves G,Million Women Study Collaborators.

    更新日期：2016-11-01 00:00:00

  • Anterograde sinuatrial conduction evaluated by sinus node electrogram in atropine blocked retrograde atrial conduction.

    abstract：:Two cases are described where atropine induced the disappearance of reset zone as response to premature atrial stimulation for blocked retrograde atrial conduction. Because of this, sinuatrial conduction time could not be estimated. The sinus node electrogram allowed the direct measurement of sinuatrial conduction and...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(85)90054-3

    authors： Padeletti L,Michelucci A,Fradella GA

    更新日期：1985-03-01 00:00:00

  • Pathogenesis of various forms of double outlet right ventricle in mouse fetal trisomy 13.

    abstract：:The pathogenesis of double outlet right ventricle with or without pulmonary infundibular atresia in mouse fetal trisomy 13 was studied at the organ level using microdissection and scanning electron microscopy. Altogether, 394 karyotyped trisomic embryos were collected between 11 days and 16 hours of gestation (presenc...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(91)90359-w

    authors： Vuillemin M,Pexieder T,Winking H

    更新日期：1991-11-01 00:00:00

  • Stress echocardiography for risk stratification of asymptomatic patients with type 2 diabetes mellitus.

    abstract：BACKGROUND:The purpose of this study was to assess stressechocardiography (SE) for risk stratification of asymptomatic type 2 diabetic patients (DM2) without known coronary artery disease CAD. METHODS:A total of 211 consecutive, asymptomatic DM2 patients underwent exercise (n=177) or dobutamine (n=34) SE and were foll...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2007.07.085

    authors： Fateh-Moghadam S,Reuter T,Htun P,Plöckinger U,Dietz R,Bocksch W

    更新日期：2009-01-09 00:00:00

  • A systematic review and meta-regression of temporal trends in the excess mortality associated with diabetes mellitus after myocardial infarction.

    abstract：BACKGROUND/OBJECTIVES:It is not well known whether the gap in outcomes after myocardial infarction (MI) between patients with and without diabetes mellitus (DM) has changed over time. We performed a systematic review and metaregression of temporal trends in the excess mortality associated with DM after MI. METHODS:We ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.ijcard.2016.04.182

    authors： Bauters C,Lemesle G,de Groote P,Lamblin N

    更新日期：2016-08-15 00:00:00