Abstract:
BACKGROUND:We assessed the hypothesis whether behavioral stress may affect the development of atherosclerosis and whether regular exercise training may influence the composition of atherosclerotic plaques in apolipoprotein (apo) E-deficient mice. METHODS:Atherosclerosis was induced in apo E-deficient mice fed a high fat diet. Exercise training (45 min swimming, 3 times/week) was conducted, and behavioral stress was provoked by glass marble-burying procedure. Mice were treated with marble-burying, marble-burying behavior plus swimming training, and swimming alone over 8 weeks. RESULTS:Exercise training decreased the atherosclerotic lesions, but marble-burying behavior increased the lesions. The plaques containing macrophage accumulation with intercellular adhesion molecule-1 (ICAM-1) expression associated with reduced collagen contents were induced in the mice treated with marble-burying. However, ICAM-1 expression was suppressed and collagen contents were reversed in the mice that received marble-burying behavior plus exercise training. In addition, exercise alone and concomitant exercise training reduced the superoxide production in aortic walls, shown by dihydroethidium staining, compared with that in mice with marble-burying behavior alone. There were no significant differences in the serum lipids profiles among the groups. CONCLUSIONS:Behavioral stress increased the atherosclerotic lesions and induced the adhesion molecule expression with superoxide production on the lesions in apo E-deficient mice. Exercise training may stabilize plaque lesions induced by marble-burying behavior in this animal model.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Shimada K,Mikami Y,Murayama T,Yokode M,Fujita M,Kita T,Kishimoto Cdoi
10.1016/j.ijcard.2010.05.057subject
Has Abstractpub_date
2011-09-15 00:00:00pages
284-9issue
3eissn
0167-5273issn
1874-1754pii
S0167-5273(10)00454-7journal_volume
151pub_type
杂志文章abstract::Pulse wave analysis (PWA) by radial arterial tonometry is receiving increasing attention for the assessment of central vascular compliance in younger patients. We present five PWA studies performed prospectively on a patient with severe coronary artery disease, and find that the measures of central augmented pressure ...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2009.03.015
更新日期:2011-05-19 00:00:00
abstract:BACKGROUND:Optical coherence tomography (OCT) is an intravascular imaging modality capable of providing in situ images of tissues at near histologic resolution. In this study we examine the utility of OCT in identifying vascular changes related to pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmona...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.07.215
更新日期:2016-11-01 00:00:00
abstract::The effects of disopyramide on the atrial fibrillation threshold (AFT) in the human atrium were investigated. To evaluate atrial vulnerability, the following electrophysiologic parameters were measured before and after the administration of disopyramide (2 mg/kg) in 12 patients with paroxysmal atrial fibrillation: The...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
doi:10.1016/0167-5273(95)02467-b
更新日期:1995-11-24 00:00:00
abstract::We assessed heart rate variability (HRV) and high-sensitivity C-reactive protein (CRP) serum levels in 77 patients with chronic stable angina (CSA), 47 of whom had obstructive coronary artery disease (CAD) and 30 normal or near-normal coronary arteries (NCA). The effect of percutaneous coronary interventions (PCI) and...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.04.015
更新日期:2008-07-04 00:00:00
abstract:BACKGROUND:The efficacy and safety of warfarin for stroke prevention in atrial fibrillation (AF) depend on the time in the therapeutic range (TTR) with an international normalised ratio (INR) of 2.0-3.0. This meta-analysis focused the relative efficacy and safety of non-VKA oral anticoagulants (NOAC) compared with warf...
journal_title:International journal of cardiology
pub_type: 杂志文章,meta分析
doi:10.1016/j.ijcard.2017.06.004
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Hyperthyroidism is a major cause of paroxysmal atrial fibrillation (AF). The purpose of this study was to evaluate the predictors of AF in the patients with clinical and subclinical hyperthyroidism. METHODS AND RESULTS:The study population consisted of four groups: group I (57 euthyroid healthy persons), gr...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2003.11.040
更新日期:2005-03-10 00:00:00
abstract::Persistence or recurrence of angina after successful percutaneous coronary intervention (PCI) represent an important clinical issue involving from one fifth to one third of patients undergoing myocardial revascularization at one-year follow-up. A systematic approach to this syndrome is strongly needed. Precision medic...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2017.07.105
更新日期:2017-12-01 00:00:00
abstract::Seventy-one patients submitted routinely to coronary artery bypass surgery were randomized into 2 groups. Group A (32 patients) received 24 hr after initiation of surgery an intravenous perfusion of 100 mg of acebutolol given over 24 hr (22 cases) or 600 mg administered orally (10 cases). On subsequent days, they rece...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0167-5273(85)90219-0
更新日期:1985-07-01 00:00:00
abstract::A 40-year-old man with severe sleep apnoea syndrome presented significant sinus pauses during a 48 h electrocardiogram Holter recording. Holter analysis showed one sinus pause of 6.4 s duration, and many pauses greater than 3 s. The 48 h Holter reevaluation, after a continuous positive air pressure device was applied,...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(98)00255-1
更新日期:1998-12-31 00:00:00
abstract::Over a 46-month period 181 pacemaker procedures were performed from an outpatient practice. Patients were admitted, operated on and discharged all within a 24-hour period. There were no pacemaker emergencies, major complications or emergency readmissions. The outpatient approach to permanent pacemaker procedures was n...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(87)90128-8
更新日期:1987-11-01 00:00:00
abstract:BACKGROUND:Acute heart failure (HF) is a frequently encountered cardiac condition. Its prevalence increases exponentially with age. In spite of this, elderly patients are underrepresented in clinical trials and the implementation of guideline-based medical therapy (GBMT) in them is not well established. We investigated...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.02.070
更新日期:2017-05-15 00:00:00
abstract:BACKGROUND:Coronary artery spasm (CAS) is known to be a risk factor of acute coronary syndrome and angina pectoris. However, there is no currently available data with larger study population regarding long-term clinical outcomes of CAS in real world clinical practice. OBJECTIVES:We evaluated the prevalence of CAS and ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2015.02.021
更新日期:2015-04-01 00:00:00
abstract::Cardiac pacing from either endocardial or transesophageal sites has proven useful in termination of sustained supraventricular tachycardia in children. In two patients we demonstrated the efficacy of external pacing in the termination of sustained supraventricular tachycardia. The ease and apparent safety of the techn...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(90)90056-b
更新日期:1990-08-01 00:00:00
abstract::Further efforts in controlling blood pressure are warranted in patients with hypertension. Office blood pressure measurements, 24-h ambulatory blood pressure monitoring and home blood pressure monitoring are synergic techniques. But, according to available evidence about efficacy and cost-effectiveness of all these te...
journal_title:International journal of cardiology
pub_type: 评论,信件
doi:10.1016/j.ijcard.2009.05.044
更新日期:2010-11-05 00:00:00
abstract:INTRODUCTION:Although acute myocardial infarction (AMI) is a disease predominantly affecting adults >60 years of age, a significant proportion of the young population who have different risk profiles, are also affected. We undertook a retrospective analysis using National Inpatient Sample (NIS) 2010 to 2014 to evaluate...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2019.11.096
更新日期:2020-02-15 00:00:00
abstract::A 68-year-old man with septic discitis of low lumbar spine is presented. The patient suffered an acute hemorrhagic stroke due to rupture of mycotic aneurysm. Streptococcus bovis biotype I was found in blood cultures. Echocardiography showed bioprosthesis aortic endocarditis. Cardiac surgery was not performed because o...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2005.02.026
更新日期:2006-03-22 00:00:00
abstract:BACKGROUND:Data with animal cells and models suggest that thrombin activates cardiac fibroblasts (Fib) to myofibroblasts (myoFib) via protease-activated receptor 1 (PAR1) cleavage, and in this way promotes adverse atrial remodeling and, thereby, atrial fibrillation (AF). OBJECTIVE:Here, we explored the effects of thro...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.05.033
更新日期:2018-11-15 00:00:00
abstract:OBJECTIVES:To determine whether calcifications of the coronary arteries (coronary artery calcium 0 to 4 score), or extending the assessment also to cardiac valves and thoracic aorta (overall calcium 0 to 8 score), as seen on computed tomography for attenuation correction during stress-scintigraphy (SPECT-CT), are assoc...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2020.03.032
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:A negative interaction has been shown to exist between aspirin and angiotensin-converting enzyme inhibitors (ACE-I) in subjects with heart failure. We explored the effect of combined ACE-I and aspirin therapy compared to ACE-I without aspirin on clinical outcomes in patients with heart failure. METHODS:430 ...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
doi:10.1016/s0167-5273(02)00401-1
更新日期:2003-04-01 00:00:00
abstract::Interrupted aortic arch (IAA) is a scarce and generally lethal congenital malformation. Patients with complete IAA scarcely reach adult age without previous surgical intervention. In this case, we presented a 40-year-old isolated IAA case with hypertension and angina pectoris. IAA just distal to left subclavian artery...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2008.06.059
更新日期:2010-02-04 00:00:00
abstract:BACKGROUND:The underlying molecular mechanisms of the remodeling after myocardial infarction (MI) remain unclear. The purpose of this study was to investigate the role of a survival pathway (PI3K/Akt) and an apoptosis pathway (calcineurin/BAD) in the remodeling after MI in a large animal model. METHODS:Ten Dorset hybr...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2011.10.107
更新日期:2013-06-05 00:00:00
abstract::In the case of patients with Takayasu arteritis (TA), they consult a doctor for the first time when they have a slight fever, shoulder pain, chest pain, back pain, or headache, or when they are pointed out to have high CRP or anemia by chance in medical check-up. In TA, they are usually young women. In our case, the v...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.05.041
更新日期:2008-04-10 00:00:00
abstract::We evaluated the effects of acetylstrophanthidin on baroreflex sensitivity in patients soon after an acute myocardial infarction. Baroreflex control of heart rate is frequently depressed after acute myocardial infarction and few data are available as to the effects of pharmacological intervention on this parameter. Th...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
doi:10.1016/0167-5273(93)90131-y
更新日期:1993-08-01 00:00:00
abstract:BACKGROUND:The use of temporary mechanical circulatory support (tMCS) during arrhythmia is increasing, although available evidence for this indication is limited, with significant gaps of knowledge regarding appropriate timing, management and configuration. This systematic review sought to analyze the use of tMCS in pa...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2020.03.045
更新日期:2020-06-01 00:00:00
abstract::In-stent Restenosis (ISR) is the Achilles heel for using of stent. Vascular brachytherapy (VBT) has been the principal scientifically investigated local therapy for coronary artery ISR. In our suggested method, a new type of stent, which is coated with Boron ((10)B) compound, is used. The coating layer of the stent co...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2008.04.036
更新日期:2009-08-14 00:00:00
abstract:BACKGROUND:Constrictive pericarditis is a rare complication of open heart surgery (OHS), but little is known regarding the etiologic determinants, and prognostic factors. The purpose of this study was to investigate clinical predictors and long term prognosis of post-operative constrictive pericarditis (CP). METHODS:U...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2020.12.090
更新日期:2021-01-06 00:00:00
abstract:BACKGROUND/OBJECTIVES:Familial hypercholesterolemia (FH) is a genetic disorder that leads to premature heart disease or stroke if untreated. Statins are effective for individuals with FH but less than 20% of actual cases are diagnosed in the US and many people are not adherent to treatment. Using new knowledge regardin...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.12.070
更新日期:2015-02-15 00:00:00
abstract:BACKGROUND:Early angiotensin-converting enzyme (ACE) inhibition is able to re-program spontaneously hypertensive rats (SHR) to express an attenuated form of disease in adulthood. METHODS:Three groups of animals (n=5 each) were studied: Wistar male rats, SHR males, and SHR males obtained from dams treated with enalapri...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2004.03.029
更新日期:2005-05-25 00:00:00
abstract::In this study, the effect of celiprolol (beta-1-antagonist with beta-2-agonistic activity) on hemodynamic and electrocardiographic parameters of patients with congestive heart failure due to ischemic (iCMP) and non-ischemic (niCMP) origin should be evaluated. Sixteen patients were included into the study, nine with iC...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
doi:10.1016/s0167-5273(98)00377-5
更新日期:1999-03-15 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate whether high-sensitivity C-reactive protein (hsCRP) levels prior to cardioversion (CV) predict recurrence of atrial fibrillation (AF) in patients randomized to treatment with either atorvastatin or placebo 30 and 180 days after CV. METHODS:This was a prespecified sub...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ijcard.2012.05.071
更新日期:2013-09-01 00:00:00