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Different effect of percutaneous and surgical coronary revascularization on cardiac autonomic function and inflammation in patients with stable angina.

Abstract：

:We assessed heart rate variability (HRV) and high-sensitivity C-reactive protein (CRP) serum levels in 77 patients with chronic stable angina (CSA), 47 of whom had obstructive coronary artery disease (CAD) and 30 normal or near-normal coronary arteries (NCA). The effect of percutaneous coronary interventions (PCI) and bypass surgery (CABG) on HRV and CRP was assessed in 36 patients (18 PCI, 18 CABG) 6 months after the intervention. A significant inverse correlation was found between CRP levels and HRV variables in CAD patients (best r value=-0.31, p=0.036 for very low frequency amplitude), but not in NCA patients. At follow-up, however, no significant correlation was found between CRP and HRV in PCI and CABG treated patients. Thus, while confirming the presence of a relation between cardiac autonomic dysfunction and inflammation in CAD patients, our data show that the association is lost after revascularization procedures.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Santangeli P,Sgueglia GA,Sestito A,Lamendola P,Mariani L,Infusino F,Niccoli G,Crea F,Lanza GA

doi

10.1016/j.ijcard.2007.04.015

subject

Has Abstract

pub_date

2008-07-04 00:00:00

pages

269-70

issue

2

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(07)00859-5

journal_volume

127

pub_type

信件

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