Abstract:
BACKGROUND:The aim of this study was to investigate whether high-sensitivity C-reactive protein (hsCRP) levels prior to cardioversion (CV) predict recurrence of atrial fibrillation (AF) in patients randomized to treatment with either atorvastatin or placebo 30 and 180 days after CV. METHODS:This was a prespecified substudy of 128 patients with persistent AF randomized to treatment with atorvastatin 80 mg/day or placebo, initiated 14 days before CV, and continued 30 days after CV. HsCRP levels were measured at randomization, at the time of CV, and 2 days and 30 days after CV. RESULTS:In univariate analysis of those who were in sinus rhythm 2h after CV, hsCRP did not significantly (odds ratio [OR] 1.11, 95% confidence interval [CI] 0.99-1.25) predict recurrence of AF at 30 days. However, after adjusting for treatment with atorvastatin, hsCRP predicted the recurrence of AF (OR 1.14, 95% CI 1.01-1.27). In a multivariate logistic regression analysis with gender, age, body mass index (BMI), smoking, cholesterol, and treatment with atorvastatin as covariates, the association was still significant (OR 1.14, 95% CI 1.01-1.29). Six months after CV, hsCRP at randomization predicted recurrence of AF in both univariate analysis (OR 1.30, 95% CI 1.06-1.60) and in multivariate logistic regression analysis (OR 1.33, 95% CI 1.06-1.67). CONCLUSION:HsCRP was associated with AF recurrence one and six months after successful CV of persistent AF. However, the association at one month was significant only after adjusting for atorvastatin treatment.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Höglund N,Andersson J,Almroth H,Tornvall P,Englund A,Rosenqvist M,Jensen SM,Boman Kdoi
10.1016/j.ijcard.2012.05.071subject
Has Abstractpub_date
2013-09-01 00:00:00pages
2088-91issue
5eissn
0167-5273issn
1874-1754pii
S0167-5273(12)00717-6journal_volume
167pub_type
杂志文章,多中心研究,随机对照试验abstract::A 19-year-old man had a documented ventricular fibrillation during a football match. He was a top-level athlete, and after successful resuscitation, he was extensively studied. Electrolytic disturbances, long QT syndrome and nervous mechanisms were all ruled out. Right and left ventriculography, coronary angiograms, e...
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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abstract:BACKGROUND:Individuals who experience paroxysmal atrial fibrillation (PAF) are at risk of serious sequelae, including stroke. PAF episodes usually occur in out-of-hospital settings, and patients seek emergency services for differential diagnosis and treatment. METHODS:Medical records of all subscribers to a telemedica...
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