当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF CARDIOLOGY期刊下所有文献 > Clinical and pharmacological significance of alpha2-adrenoceptor polymorphisms in cardiovascular diseases.

Clinical and pharmacological significance of alpha2-adrenoceptor polymorphisms in cardiovascular diseases.

Abstract：

:The alpha2-adrenoceptors (alpha2-ARs) are receptors for endogenous catecholamines (norepinephrine and epinephrine) that mediate a number of physiological and pharmacological responses such as hypotension and sedation. Three distinct subtypes, denoted alpha2A-, alpha2B- and alpha2C-AR, have been characterized and cloned. Employment of mutation screening in the study of human populations from various ethnic backgrounds has shown that alpha2-AR genes are polymorphic. The functional and biochemical consequences of these polymorphisms have been analyzed by expressing the wild-type receptors and their respective genetic variants in heterologous systems such as CHO and COS-7 cells. Changes include alteration in G-protein coupling and in agonist-promoted receptor phosphorylation and desensitization. Case-control and population-based studies have shown clinical association with cardiovascular risk. Further investigation of the genetic variants in specialized cells and transgenic animals will provide the molecular basis of cardiovascular disease and may reveal alpha2-AR variants as potential targets for selective pharmacological interventions.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Flordellis C,Manolis A,Scheinin M,Paris H

doi

10.1016/j.ijcard.2003.10.014

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

367-72

issue

3

eissn

0167-5273

issn

1874-1754

pii

S0167527304000038

journal_volume

97

pub_type

杂志文章,评审

相关文献

INTERNATIONAL JOURNAL OF CARDIOLOGY文献大全
  • Implications for single phase prospective CT coronary angiography for the diagnosis of significant coronary stenoses in clinical practice.

    abstract：BACKGROUND:CT coronary angiography (CTA) with 64 slice multi-detector CT (64-MDCT) has assumed an increasing role in clinical practice; however the high radiation dose associated with retrospective ECG-gated CTA has led to suggestions that a low dose prospectively gated strategy may be more appropriate. This study aims...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2009.09.542

    authors： Sá MI,Nicol ED,Stirrup J,Crean A,Roughton M,Padley SP,Rubens MB

    更新日期：2011-03-17 00:00:00

  • Peripheral blood transcriptome sequencing reveals rejection-relevant genes in long-term heart transplantation.

    abstract：BACKGROUND:Peripheral blood-based gene expression patterns have been investigated as biomarkers to monitor the immune system and rule out rejection after heart transplantation. Recent advances in the high-throughput deep sequencing (HTS) technologies provide new leads in transcriptome analysis. METHODS:By performing S...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2013.03.095

    authors： Chen Y,Zhang H,Xiao X,Jia Y,Wu W,Liu L,Jiang J,Zhu B,Meng X,Chen W

    更新日期：2013-10-03 00:00:00

  • Resting heart rate and cardiac function in dilated cardiomyopathy.

    abstract：:We hypothesized that, within the normal range of resting heart rate, heart rate and left ventricular ejection fraction would be inversely correlated and heart rate and left ventricular filling would be correlated in patients with dilated cardiomyopathy and not correlated in patients with normal cardiac function. At re...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/s0167-5273(99)00139-4

    authors： Clements IP,Miller WL,Olson LJ

    更新日期：1999-12-15 00:00:00

  • Cost-effectiveness of a management strategy based on exercise echocardiography versus exercise electrocardiography in patients presenting with suspected angina during long term follow up: A randomized study.

    abstract：INTRODUCTION:Exercise ECG (Ex-ECG) is advocated by guidelines for patients with low - intermediate probability of coronary artery disease (CAD). However, there are no randomized studies comparing Ex-ECG with exercise stress echocardiography (ESE) evaluating long term cost-effectiveness of each management strategy. MET...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ijcard.2018.01.112

    authors： Gurunathan S,Zacharias K,Akhtar M,Ahmed A,Mehta V,Karogiannis N,Vamvakidou A,Khattar R,Senior R

    更新日期：2018-05-15 00:00:00

  • Updated evidence on early statin therapy for acute coronary syndromes: meta-analysis of 18 randomized trials involving over 14,000 patients.

    abstract：BACKGROUND:The short-term effects of early statin therapy in acute coronary syndromes (ACS) on clinical outcomes remain unclear. Our objective was to update the evidence on patient relevant outcomes from all randomized trials comparing early statin therapy with placebo or usual care at 1 and 4 months following ACS. ME...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.ijcard.2011.01.033

    authors： Briel M,Vale N,Schwartz GG,de Lemos JA,Colivicchi F,den Hartog FR,Ostadal P,Macin SM,Liem A,Mills E,Bhatnagar N,Bucher HC,Nordmann AJ

    更新日期：2012-06-28 00:00:00

  • Clinical outcome of patients undergoing multivessel coronary stent implantation.

    abstract：OBJECTIVES:To evaluate the outcome of patients undergoing multivessel coronary stent implantation. BACKGROUND:Percutaneous transluminal coronary angioplasty has been shown to be an effective treatment for multivessel coronary artery disease, although the need for repeat revascularization continues to be a limitation. ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/s0167-5273(97)00333-1

    authors： Mathew V,Rihal CS,Berger PB,Bell MR,Garratt KN,Holmes R Jr

    更新日期：1998-03-13 00:00:00

  • Statins attenuate but do not eliminate the reverse epidemiology of total serum cholesterol in patients with non-ischemic chronic heart failure.

    abstract：BACKGROUND:In patients with chronic heart failure (CHF) increasing levels of total serum cholesterol are associated with improved survival - while statin usage is not. The impact of statin treatment on the "reverse epidemiology" of cholesterol is unclear. METHODS:2992 consecutive patients with non-ischemic CHF due to ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2017.03.028

    authors： Fröhlich H,Raman N,Täger T,Schellberg D,Goode KM,Kazmi S,Grundtvig M,Hole T,Cleland JGF,Katus HA,Agewall S,Clark AL,Atar D,Frankenstein L

    更新日期：2017-07-01 00:00:00

  • Cardiac MR1 and peripartum cardiomyopathy.

    abstract：:Cardiac MRI brings great benefits in the comprehension of the mechanism(s) involved in the genesis of peripartum cardiomyopathy (PPC). Cardiac MRI may also procure prognostic information. Because this is a rare affection, it seems necessary to systematically study PPC with this safe, non invasive and reliable tool. Cr...

    journal_title：International journal of cardiology

    pub_type： 评论,信件

    doi：10.1016/j.ijcard.2008.11.142

    authors： Leurent G

    更新日期：2010-07-23 00:00:00

  • Metoprolol in acute myocardial infarction reduces ventricular arrhythmias both in the early stage and after the acute event.

    abstract：:Fifty three of the 5778 patients included in the MIAMI (Metoprolol in Acute Myocardial Infarction) trial were investigated with long-term ECG recordings in order to evaluate the effect of acute beta-blockade on premature ventricular complexes in and after acute myocardial infarction. Twenty five patients were given pl...

    journal_title：International journal of cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0167-5273(87)90335-4

    authors： Rehnqvist N,Olsson G,Erhardt L,Ekman AM

    更新日期：1987-06-01 00:00:00

  • The placenta: A site of end-organ damage after Fontan operation. A case series.

    abstract：BACKGROUND:Placental insufficiency may be the cause of the high preterm birth rate in women after Fontan operation. In this study we reviewed the clinical course and pregnancy outcome of women with Fontan physiology with a focus on placental pathology. METHODS:We reviewed clinical charts and placental pathology from 7...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2019.02.002

    authors： Phillips AL,Cetta F,Kerr SE,Cheek EH,Rose CH,Bonnichsen CR,Phillips SD

    更新日期：2019-08-15 00:00:00

  • A systematic review and meta-regression of temporal trends in the excess mortality associated with diabetes mellitus after myocardial infarction.

    abstract：BACKGROUND/OBJECTIVES:It is not well known whether the gap in outcomes after myocardial infarction (MI) between patients with and without diabetes mellitus (DM) has changed over time. We performed a systematic review and metaregression of temporal trends in the excess mortality associated with DM after MI. METHODS:We ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.ijcard.2016.04.182

    authors： Bauters C,Lemesle G,de Groote P,Lamblin N

    更新日期：2016-08-15 00:00:00

  • Homocysteine-lowering vitamins and cardiovascular mortality: are they really effective?

    abstract：:In the light of current data obtained from prospective outcome studies, we believe that it is premature to support the use of homocysteine-lowering vitamins including folic acid in patients with established coronary artery disease in order to improve cardiovascular outcomes. We think that future large-scale epidemiolo...

    journal_title：International journal of cardiology

    pub_type： 评论,信件

    doi：10.1016/j.ijcard.2007.05.044

    authors： Celik T,Iyisoy A,Yuksel UC,Isik E

    更新日期：2008-08-29 00:00:00

  • Congestive heart failure due to aortic incompetence with intestinal infarction due to endarteritis obliterans.

    abstract：:A 27-year-old man with congestive heart failure due to aortic incompetence and subsequent intestinal infarction was found at laparotomy to have extensive necrosis of the bowel due to proliferative endarteritis. Symptoms resolved following treatment with prednisolone and cyclophosphamide, and replacement of the aortic ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(91)90017-j

    authors： Purvis JA,Adgey AA,O'Hara MD

    更新日期：1991-03-01 00:00:00

  • Aortic valve sparing operations: basic concepts.

    abstract：:Aortic valve sparing surgery offers a unique opportunity to save the normal aortic valve in patients who require surgery for aortic root disease such as aneurysms, annuloaortic ectasia or aortic dissection. The surgical anatomy of the aortic root and the basic concepts of aortic valve sparing surgery are reviewed to p...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijcard.2004.08.010

    authors： Feindel CM,David TE

    更新日期：2004-12-01 00:00:00

  • Impact of time of admission on short- and long-term mortality in the Vienna STEMI registry.

    abstract：BACKGROUND:Several studies have shown contradictive findings regarding mortality and hospital admission time in patients presenting with ST-elevation myocardial infarction (STEMI). The aim of this study was to assess the impact of "on-" or "off-hour" admission on short- and long-term all-cause mortality of patients in ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ijcard.2017.03.029

    authors： Tscharre M,Jäger B,Farhan S,Christ G,Schreiber W,Weidinger F,Stefenelli T,Delle-Karth G,Kaff A,Maurer G,Huber K,Vienna STEMI Registry Group.

    更新日期：2017-10-01 00:00:00

  • Unusual cause of syncope in a 17 year-old young woman: left ventricular hydatid cyst.

    abstract：:Cardiac involvement in echinococcosis remains a singular finding, possibly associated with confusing symptomatology. We report the original case of a 17 year-old young woman, referred to our cardiology department for repeated exertion syncopes, and ultimately, proven through echocardiography, serologies and magnetic r...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2008.04.077

    authors： Rekik S,Krichene S,Sahnoun M,Trabelsi I,Kharrat I,Charfeddine H,Triki F,Hentati M,Kammoun S

    更新日期：2009-07-24 00:00:00

  • Giant epicardial lipoma.

    abstract：:A patient undergoing coronary artery bypass was found to have a giant epicardial lipoma weighing 1.36 kg which was excised uneventfully. The radiological and pathophysiological features are considered, and the options for management discussed. ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(92)90140-x

    authors： Eng J,Ruiz K,Kay PH

    更新日期：1992-10-01 00:00:00

  • Effects of amlodipine and lacidipine on heart rate variability in hypertensive patients with stable angina pectoris and isolated left ventricular diastolic dysfunction.

    abstract：OBJECTIVE:To estimate the influence of therapy with amlodipine (A) or lacidipine (L) on heart rate variability (HRV) time and frequency domain parameters in hypertensive patients with stable angina pectoris and isolated left ventricular diastolic dysfunction. METHODS:After a 1-week washout period, the patients were ra...

    journal_title：International journal of cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.ijcard.2004.03.040

    authors： Zaliūnas R,Brazdzionyte J,Zabiela V,Jurkevicius R

    更新日期：2005-06-08 00:00:00

  • Gender-specific risk stratification with plasma B-type natriuretic peptide for future onset of congestive heart failure and mortality in the Japanese general population.

    abstract：BACKGROUND:Elevated plasma B-type natriuretic peptide (BNP) levels suggest a high risk for future onset of cardiovascular events including congestive heart failure (CHF) and mortality. In the general population, although median plasma BNP levels have been reported to be higher in women than in men, the incidence of CHF...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2009.01.076

    authors： Nakamura M,Tanaka F,Onoda T,Takahashi T,Sakuma M,Kawamura K,Tanno K,Ohsawa M,Itai K,Sakata K,Makita S,Iwate KENCO Study Groups.

    更新日期：2010-08-20 00:00:00

  • Implanted defibrillators and primary prevention of sudden cardiac death: where are we today?

    abstract：:Implanted defibrillators have become a mainstream therapy for the prevention of sudden cardiac death (SCD) from ventricular tachyarrhythmias in patients with chronic coronary artery disease. A decade of studies has confirmed the superiority of ICDs over antiarrhythmic drug therapy in prolonging the life of patients wi...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijcard.2003.10.032

    authors： Ray IB,Reddy VY

    更新日期：2005-01-01 00:00:00

  • Vitamin D and cardiovascular disease: From atherosclerosis to myocardial infarction and stroke.

    abstract：:There continues to be interest in understanding the role of vitamin D in the pathogenesis, epidemiology and prevention of cardiovascular disease (CVD). In fact vitamin D deficiency has been associated to an increased risk of developing CVD given to the relationship between low vitamin D levels and obesity, diabetes me...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijcard.2016.12.053

    authors： Muscogiuri G,Annweiler C,Duval G,Karras S,Tirabassi G,Salvio G,Balercia G,Kimball S,Kotsa K,Mascitelli L,Bhattoa HP,Colao A

    更新日期：2017-03-01 00:00:00

  • Three-year follow-up of patients with acetylcholine-induced coronary artery spasm combined with insignificant coronary stenosis.

    abstract：BACKGROUND:Coronary artery spasm (CAS) and significant coronary stenosis are known to be major causes of myocardial ischemia. However, their association and the impact of insignificant coronary stenosis (ICS) on long-term clinical outcomes of CAS patients are largely unknown. METHODS:A total of 2797 patients without s...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2017.03.081

    authors： Choi BG,Park SH,Rha SW,Ahn J,Choi SY,Byun JK,Li H,Mashaly A,Shim MS,Kang JH,Kim W,Choi JY,Park EJ,Lee S,Na JO,Choi CU,Lim HE,Kim EJ,Park CG,Seo HS,Oh DJ

    更新日期：2017-07-01 00:00:00

  • Differential prognosis of vasospastic angina according to presentation with sudden cardiac arrest or not: Analysis of the Korean Health Insurance Review and Assessment Service.

    abstract：BACKGROUND:The long-term prognosis of vasospastic angina (VSA) patients presenting with aborted sudden cardiac death (ASCD) is still unknown. We sought to compare the long-term clinical outcomes between VSA patients presenting with and without ASCD by retrospective analysis of a nationwide population-based database. M...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2018.09.082

    authors： Park TK,Gwag HB,Park SJ,Park H,Kang D,Park J,Cho J,Chung CR,Jeon K,Suh GY,Guallar E,Cho J,Yang JH

    更新日期：2018-12-15 00:00:00

  • Cardiac effects of exercise rehabilitation in hemodialysis patients.

    abstract：:Exercise training has well documented beneficial effects in a variety of cardiac disorders. End stage renal disease patients present many cardiovascular complications and suffer from impaired exercise capacity. No study to date has adequately examined the cardiac responses to exercise training in renal patients on hem...

    journal_title：International journal of cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0167-5273(99)00090-x

    authors： Deligiannis A,Kouidi E,Tassoulas E,Gigis P,Tourkantonis A,Coats A

    更新日期：1999-08-31 00:00:00

  • Efficacy of intracoronary administration of a short-acting β-blocker landiolol during reperfusion in pigs.

    abstract：BACKGROUND:Although β-blockers are used to prevent myocardial ischemia/reperfusion injury, the risk of heart failure has limited β-blocker therapy in patients with acute myocardial infarction. This study evaluated efficacy of intracoronary administration of the short-acting β-blocker, landiolol, during reperfusion in p...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2009.07.013

    authors： Park H,Otani H,Oishi C,Fujikawa M,Yamashita K,Okazaki T,Sato D,Ueyama T,Iwasaka J,Yamamoto Y,Iwasaka T

    更新日期：2011-02-03 00:00:00

  • The xanthine oxidase inhibitor oxypurinol reduces cancer cachexia-induced cardiomyopathy.

    abstract：BACKGROUND:Cachexia is a common complication of cancer and may be responsible for 22% of all cancer-related deaths. The exact cause of death in cancer cachexia patients is unknown. Recently, atrophy of the heart has been described in cancer cachexia animal models, which resulted in impaired cardiac function and is like...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2013.05.063

    authors： Springer J,Tschirner A,Hartman K,von Haehling S,Anker SD,Doehner W

    更新日期：2013-10-09 00:00:00

  • Management of non-ST-elevation acute coronary syndromes: how cost-effective are glycoprotein IIb/IIIA antagonists in the UK National Health Service?

    abstract：BACKGROUND:The glycoprotein IIb/IIIa antagonists (GPAs) represent a new class of drugs to prevent platelet aggregation in the acute treatment of non-ST-elevation acute coronary syndromes (NSTE-ACS). Systematic reviews have identified serious limitations in published cost-effectiveness analyses, including a lack of UK-s...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2004.08.042

    authors： Palmer S,Sculpher M,Philips Z,Robinson M,Ginnelly L,Bakhai A,Abrams K,Cooper N,Packham C,Alfakih K,Hall A,Gray D

    更新日期：2005-04-20 00:00:00

  • Catheter ablation of atrioventricular accessory pathways by radiofrequency current.

    abstract：:Tachycardias mediated by atrioventricular accessory pathways, which are refractory to antiarrhythmic drug therapy have been treated both by surgery and by catheter ablation with high energy direct current shock. These procedures have variable success rates and substantial associated morbidity and mortality. Radiofrequ...

    journal_title：International journal of cardiology

    pub_type： 临床试验,杂志文章

    doi：10.1016/0167-5273(93)90085-u

    authors： Wang L,Hu D,Ding Y

    更新日期：1993-12-15 00:00:00

  • Brown fat like gene expression in the epicardial fat depot correlates with circulating HDL-cholesterol and triglycerides in patients with coronary artery disease.

    abstract：BACKGROUND:Recent evidence indicates that epicardial adipose tissue (EAT) expresses uncoupling protein-1 (UCP1), a marker of brown adipocytes. However, the putative effects of the presence of brown adipocytes in EAT remain unknown. METHODS:The mRNA expression of genes related to brown adipocyte-mediated thermogenesis ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2012.06.008

    authors： Chechi K,Blanchard PG,Mathieu P,Deshaies Y,Richard D

    更新日期：2013-09-01 00:00:00

  • Lipoprotein(a) is strongly associated with coronary artery calcification in type-2 diabetic women.

    abstract：BACKGROUND:Lp(a), implicated in both atherogenesis and thrombosis pathways, varies significantly by demographic and metabolic factors, providing challenges for its use in Coronary Heart Disease (CHD) risk. The purpose of this study was to investigate whether type-2 diabetic subjects, relative to non-diabetics, might be...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2010.02.021

    authors： Qasim AN,Martin SS,Mehta NN,Wolfe ML,Park J,Schwartz S,Schutta M,Iqbal N,Reilly MP

    更新日期：2011-07-01 00:00:00