Abstract:
BACKGROUND:Endothelial progenitor cells (EPCs) circulate in the adult peripheral blood and contribute to neovascularization. EPCs are considered to be included in CD34 positive mononuclear cells (CD34+ MNCs). Kinetics of circulating EPCs in congestive heart failure (CHF) has not been fully investigated. METHODS:We determined the numbers of white blood cells (WBCs), plasma brain natriuretic peptide (BNP), serum erythropoietin, vascular endothelial growth factor (VEGF) and thrombomodulin levels in 16 mild CHF patients (NYHA I, II), 10 severe CHF patients with acute exacerbation (NYHA III, IV), and 22 control subjects. The number of CD34+ MNCs in peripheral blood was quantified by flow cytometry. RESULTS:The ratio of CD34+ MNCs:10(3) WBCs in mild CHF patients was higher than that in control subjects (P<0.05). Interestingly, the ratio of CD34+ MNCs:10(3) WBCs in severe CHF patients at admission was significantly lower than that in control subjects (P<0.005) or in mild CHF patients (P<0.05). Levels of BNP and erythropoietin in severe CHF patients were significantly higher than those in mild CHF patients. However, VEGF and thrombomodulin levels were not different between mild and severe CHF patients. In addition, the ratio of CD34+ MNCs:10(3) WBCs in severe CHF patients increased in proportion to the amelioration of CHF during hospitalization, and this increase correlated with the decrease in BNP level. CONCLUSIONS:The ratio of CD34+ MNCs:10(3) WBCs was decreased in severe CHF. These findings suggest that impaired EPC recruitment might be involved in the pathophysiology of severe CHF.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Nonaka-Sarukawa M,Yamamoto K,Aoki H,Nishimura Y,Tomizawa H,Ichida M,Eizawa T,Muroi K,Ikeda U,Shimada Kdoi
10.1016/j.ijcard.2006.07.191subject
Has Abstractpub_date
2007-07-31 00:00:00pages
344-8issue
3eissn
0167-5273issn
1874-1754pii
S0167-5273(06)01046-1journal_volume
119pub_type
杂志文章abstract:BACKGROUND:While the impact of mitral regurgitation (MR) prior to transcatheter aortic valve replacement (TAVR) has been intensively studied, the implications of post-procedural MR on outcome are unknown. We investigated the clinical and physiological impact of significant MR after TAVR. METHODS:Clinical and echocardi...
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
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abstract:BACKGROUND:Aortic pressure waveforms are calculated non-invasively by applying generalized transfer functions (GTF) to tonometric radial pressure waveforms. Input errors mainly during acquisition and calibration of tonometric pressures are "transferred" to aortic pressure calculation. The present study aimed to quantif...
journal_title:International journal of cardiology
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1994-01-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2008-01-24 00:00:00
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journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
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journal_title:International journal of cardiology
pub_type: 杂志文章,评审
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journal_title:International journal of cardiology
pub_type: 信件
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2008-02-29 00:00:00
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pub_type: 杂志文章,meta分析,评审
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