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Cardioprotective effect of substance P in a porcine model of acute myocardial infarction.

Abstract：

BACKGROUND:Substance P (SP) may attenuate ischemia-reperfusion injury by reducing inflammation. We assessed cardioprotective effect of SP in a porcine model of acute myocardial infarction (AMI). METHODS:AMI was induced by occlusion of the left anterior descending artery on 28 swine, randomized to SP 5 nmol/kg (group 1, n = 14) and normal saline (group 2, n = 14) given intravenously 5 min before reperfusion. Blood samples were collected at baseline, 3 days and 4 weeks. Echocardiography and myocardial perfusion single photon emission computed tomography (SPECT) were performed at 1 week and 4 weeks. Histomorphometric infarct size assessment was done at 4 weeks. RESULTS:Left ventricular (LV) ejection fraction (EF) (LVEF) after AMI induction was higher in group 1 than group 2 (37.9 ± 4.6% vs. 29.4 ± 3.2%, p = 0.001) but not different at 4 weeks. No significant difference was observed in perfusion defect extent and total perfusion defect on SPECT at 1 week and 4 weeks. Pathologic infarct size (% LV) was significantly smaller in group 1 than group 2 (2.4 ± 2.3% vs. 5.7 ± 2.5%, p = 0.020). The ratio of neutrophil to lymphocyte on day 3 and serum creatinine concentration at 4 weeks after AMI were lower in group 1. CONCLUSIONS:In a porcine model of AMI, SP improved LVEF early post-MI and reduced infarct size. SP may be beneficial in reducing inflammation and ischemia-reperfusion injury after AMI.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Sim DS,Kim W,Lee KH,Song HC,Kim JH,Park DS,Lim KS,Woo JS,Hong YJ,Ahn Y,Hong HS,Son Y,Jeong MH

doi

10.1016/j.ijcard.2018.05.113

subject

Has Abstract

pub_date

2018-11-15 00:00:00

pages

228-232

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(18)32255-1

journal_volume

271

pub_type

杂志文章

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