Abstract：
:Long-QT syndrome is a clinically and genetically heterogeneous syndrome characterized by lengthening of the QT interval and increased dispersion of the ventricular repolarization on surface electrocardiogram and a propensity to malignant ventricular arrhythmias, torsade de pointes and ventricular fibrillation, which may lead to sudden cardiac death. Long-QT syndrome mostly affects adolescents and young adults with structurally and functionally normal hearts and is caused by aberrations in potassium and sodium ion channels. Standard therapies for long-QT syndrome include correction of the underlying cause, alleviation of the precipitating factors, magnesium sulfate, isoproterenol, antiadrenergic therapy (beta-adrenergic receptor blockers, left cervicothoracic sympathectomy), cardiac pacing, and implantable cardioverter defibrillator. The potential therapies include sodium channel blockers (mexiletine, flecainide, lidocaine, pentisomide, phenytoin), potassium, potassium channel activators (nicorandil, pinacidil, cromakalim), alpha-adrenergic receptor blockers, calcium channel blockers, atropine, and protein kinase inhibitors. The purpose of this review is to outline the established therapies and update the recent advances and potential future strategies in the treatment of long-QT syndrome and torsade de pointes.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Khan IA,Gowda RMdoi
10.1016/j.ijcard.2003.04.018subject
Has Abstractpub_date
2004-05-01 00:00:00pages
1-6issue
1eissn
0167-5273issn
1874-1754pii
S0167527303003450journal_volume
95pub_type
杂志文章,评审abstract：:The long preclinical phase of atherosclerosis involves the interaction of genetic and environmental factors that modulate the progression of disease from early life. Injury to the endothelium is a critical step in atherosclerotic process. Conventional and novel risk factors for coronary artery disease operate from ear...
journal_title：International journal of cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.ijcard.2005.06.010
更新日期：2006-05-10 00:00:00
abstract：BACKGROUND:Stroke is the second cause of death worldwide and over than 80% of deaths occurs in developing countries. However, its characteristics in the Democratic Republic of Congo (DRC) are poorly defined. This study aimed to describe the key features of stroke in a hospital population of Kinshasa in DRC and to asses...
journal_title：International journal of cardiology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ijcard.2017.04.063
更新日期：2017-08-01 00:00:00
abstract：:A case of hydatid cyst affecting the right ventricle is described and role of tomographic scanning highlighted as it demonstrated a typical multilocular cyst arising from the right ventricle in the patient discussed here. ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(91)90075-z
更新日期：1991-12-01 00:00:00
abstract：:I studied the prevalence and symptoms of idiopathic mitral valve prolapse by auscultation in 972 consecutive patients in an adult general medical population. Forty-five patients (4.6%) had idiopathic mitral valve prolapse defined by a nonejection click with or without a late systolic murmur. The prevalence was not sig...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(82)90069-9
更新日期：1982-01-01 00:00:00
abstract：:We analyzed the ventricular expression of atrial and brain natriuretic peptides (ANP and BNP) in patients with myocarditis. Immunohistochemical analysis of endomyocardial biopsy specimens showed ANP and BNP immunoreactivity in the early myocarditis group (ANP in 4/10 and BNP in 3/10) and the late myocarditis group (AN...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(95)02468-9
更新日期：1995-12-01 00:00:00
abstract：BACKGROUND:Recent evidence indicates that epicardial adipose tissue (EAT) expresses uncoupling protein-1 (UCP1), a marker of brown adipocytes. However, the putative effects of the presence of brown adipocytes in EAT remain unknown. METHODS:The mRNA expression of genes related to brown adipocyte-mediated thermogenesis ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2012.06.008
更新日期：2013-09-01 00:00:00
abstract：OBJECTIVES:We sought to investigate the association between LVEF and clinical outcomes after NSTEMI, and the benefit of guideline-recommended pharmacotherapy in elderly patients. BACKGROUND:New-onset reduction in LVEF is common after NSTEMI in patients of advanced age. There is little information about outcomes in rel...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2019.07.019
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND:The role of anemia in heart failure with mid-range and preserved ejection fraction (HFmrEF, EF 40-49% and HFpEF, EF ≥50%) is unknown. We aimed to compare prevalence of, associations with, and prognostic role of anemia in HF across the EF spectrum. METHODS:In patients from the Swedish HF Registry, we assesse...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2019.08.049
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVES:Assessment of the long term outcome of mechanical valve prosthesis at pulmonary position in a population of grown-up congenital heart disease patients from a tertiary referral center. METHODS:From 1977 to 2007, 22 consecutive patients underwent a total of 25 pulmonary valve replacements with mechanical pros...
journal_title：International journal of cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.ijcard.2010.04.004
更新日期：2011-07-15 00:00:00
abstract：BACKGROUND:Lower serum chloride (Cl) is associated with mortality in heart failure patients and may be more prognostically relevant than sodium. However, the association of hemodynamics and Cl levels is unknown. METHODS:438 sequential patients with advanced chronic heart failure (ACHF) underwent invasive hemodynamic a...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2017.11.024
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVES:Aim of this study was to evaluate different response in platelet reactivity and vessel healing using high-resolution frequency-domain optical coherence tomography (FD-OCT) in patients with femoropopliteal artery disease treated with ZILVER PTX drug eluting stents (DES), and randomly assigned to clopidogrel o...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2020.01.024
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:Exercise electrocardiography in asymptomatic adults has been criticized because of relatively poor accuracy predicting future heart disease risk, but studies may have been too short. We investigated if integrated analysis of graded exercise tolerance tests (GXT) predicted long-term coronary heart disease (CH...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2014.12.026
更新日期：2015-02-15 00:00:00
abstract：BACKGROUND:The efficacy and safety of thrombectomy as an adjunct to primary percutaneous intervention (PCI) in the management of acute myocardial infarction (AMI) are debated. We performed a meta-analysis of randomized trials comparing primary PCI performed with versus without routine aspiration thrombectomy (AT). MET...
journal_title：International journal of cardiology
pub_type： 杂志文章,meta分析
doi：10.1016/j.ijcard.2015.11.135
更新日期：2016-02-01 00:00:00
abstract：:Development and advances in heart pacing over the last nearly half a century allowed to save numerous lives by providing pacing support in bradycardia and complete heart block. Nevertheless, long-term follow up of patients with implanted pacemaker showed unfavorable remodeling of the heart, both from hemodynamic as we...
journal_title：International journal of cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.ijcard.2009.10.021
更新日期：2010-06-11 00:00:00
abstract：BACKGROUND:It is well known that cardiac rehabilitation (CR) including regular exercise training (ET) is cardioprotective with respect to clinical events in patients with acute myocardial infarction (AMI). However, it is not known whether the regular ET may affect coronary restenosis after percutaneous coronary interve...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2012.06.122
更新日期：2013-09-10 00:00:00
abstract：:Aberrant origin of the main stem of the left coronary artery from the right sinus of Valsalva caused angina of effort in a 40 year-old patient. Diagnosis was revealed by transoesophageal echocardiography and confirmed by selective coronary angiography. Aorto-coronary bypass was performed in order to prevent the recurr...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(91)90050-y
更新日期：1991-07-01 00:00:00
abstract：BACKGROUND:To determine the impact of circulating miRNA and protein activity on the severity of ascending aortic dilatation in patients with bicuspid (BAV) and tricuspid aortic valve (TAV). METHODS:By reverse transcription polymerase chain reaction, exosomal circulating expression levels (versus healthy aorta) of miRN...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2018.10.005
更新日期：2018-12-15 00:00:00
abstract：BACKGROUND:Acute Kidney Injury (AKI) after cardiac surgery is a complication influencing postoperative outcome. Preoperative hemoglobin is a predictor of postoperative AKI. We aimed to identify preoperative predictors of Renal Replacement Therapy (RRT) and to develop a new risk-scoring system including hemoglobin to be...
journal_title：International journal of cardiology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ijcard.2014.08.003
更新日期：2014-10-20 00:00:00
abstract：BACKGROUND:This prospective study aims to investigate the reproducibility of HUTT results in children with typical history of vasovagal syncope. METHODS:Between October 1996 and October 1999, 58 children with a history of typical vasovagal syncope attacks were evaluated with head up tilt test (HUTT). The table was til...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/s0167-5273(02)00379-0
更新日期：2003-03-01 00:00:00
abstract：:In this study we assessed whether total cholesterol content of erythrocyte membranes (CEM) was associated with the presence of acute coronary syndrome (ACS) and high sensitivity C-reactive protein (hs-CRP). Consecutive angina patients were assessed; 98 had ACS and 45 had stable angina pectoris (SAP). CEM in the ACS gr...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2009.04.018
更新日期：2010-11-05 00:00:00
abstract：BACKGROUND:Study aimed to describe the extent and the temporal profile of cardiac remodeling after atrial septal defect closure in the adult. METHODS:Prospective and longitudinal echocardiographic assessment of right and left heart size before and after (1 day-1 week/1/4/12 months) surgical or catheter-based atrial se...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2005.05.042
更新日期：2006-04-14 00:00:00
abstract：OBJECTIVE:To assess the relationship between heart rate (HR), pulse pressure (PP), and their association with mortality in a population of high-risk patients following acute myocardial infarction (MI). METHODS:We performed an analysis in 22,398 patients included in "The High-Risk Myocardial Infarction Database Initiat...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2018.05.017
更新日期：2018-11-15 00:00:00
abstract：BACKGROUND:Abnormal prolongation of QRS duration is a common finding in patients with chronic heart failure, and is associated with an impaired prognosis. The optimum QRS duration for separating chronic heart failure patients with respect to prognosis has not been determined. Whilst resynchronisation of ventricular con...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/s0167-5273(02)00270-x
更新日期：2002-12-01 00:00:00
abstract：:Takotsubo cardiomyopathy is an increasingly reported syndrome characterized by transient apical left ventricular dysfunction in absence of flow limiting coronary artery disease. Prolongation of QT interval associated with Takotsubo cardiomyopathy has been previously reported in published case series but none of these ...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2008.04.021
更新日期：2009-08-14 00:00:00
abstract：:Cardiac pacing from either endocardial or transesophageal sites has proven useful in termination of sustained supraventricular tachycardia in children. In two patients we demonstrated the efficacy of external pacing in the termination of sustained supraventricular tachycardia. The ease and apparent safety of the techn...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(90)90056-b
更新日期：1990-08-01 00:00:00
abstract：BACKGROUND:Placental insufficiency may be the cause of the high preterm birth rate in women after Fontan operation. In this study we reviewed the clinical course and pregnancy outcome of women with Fontan physiology with a focus on placental pathology. METHODS:We reviewed clinical charts and placental pathology from 7...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2019.02.002
更新日期：2019-08-15 00:00:00
abstract：:We sought to investigate the relative clinical significance of target and nontarget lesions repeated percutaneous coronary intervention (re-PCI) in patients implanted with drug-eluting stents (DES). Out of 2626 consecutive DES patients, we retrospectively selected 166 (6.3%; 123 males, aged 65±10 years) who had a clin...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2009.11.049
更新日期：2010-11-19 00:00:00
abstract：BACKGROUND:Left bundle branch block (LBBB) negatively affects prognosis in heart failure patients with a reduced left ventricular ejection fraction (LVEF). Less is known about the prognostic role of LBBB in dilated cardiomyopathy (DCM) with intermediate LVEF (between 36% and 50%). We sought to assess the role of LBBB i...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2018.11.005
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:This study assessed the acute effect of 21 days of challenging exercise on heart structure and function in recreationally active people across a range of age categories. METHODS:15 recreationally active people completed a 21-day fundraising cycling ride (MADRIDE) over a distance of 3515 km. Twenty-four hour...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2019.03.016
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:To examine whether the recent flattening of mortality rates for coronary heart disease (CHD) observed among young adults in the UK and the US is also occurring in the Australian population. METHODS:Mortality data from 1976 to 2006 were used to calculate overall age-adjusted and age-specific mortality rates ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2011.01.016
更新日期：2012-07-12 00:00:00
