Association between reduced left ventricular ejection fraction following non-ST-segment elevation myocardial infarction and long-term mortality in patients of advanced age.


OBJECTIVES:We sought to investigate the association between LVEF and clinical outcomes after NSTEMI, and the benefit of guideline-recommended pharmacotherapy in elderly patients. BACKGROUND:New-onset reduction in LVEF is common after NSTEMI in patients of advanced age. There is little information about outcomes in relation to LVEF, and the benefit of guideline-recommended pharmacotherapy in elderly patients. MATERIALS AND METHODS:The SWEDEHEART registry was used to identify all patients in Sweden >80 years with NSTEMI from 2011 to 2014. A normal LVEF was defined as >50%; mildly reduced, 40%-49%; moderately reduced, 30%-39%; and severely reduced, <30%. Cox regression was used to calculate adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) for the association between a reduced LVEF compared with a normal LVEF and all-cause mortality. Similarly, the presence versus absence of treatment with guideline-recommended medications at discharge and mortality was evaluated. RESULTS:6287 patients were included where 59%, 20%, 13%, and 6% had a normal, mildly reduced, moderately reduced, and severely reduced LVEF, respectively. During a median follow-up of 2.4 years, 2211 (35%) patients died. All three categories of impaired LVEF were associated with higher mortality: mildly reduced (1.44, 1.25-1.65), moderately reduced (1.93, 1.67-2.23), and severely reduced (3.24, 2.74-3.85). Patients who were treated with beta-blockers, angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, or statins at discharge had lower mortality. CONCLUSIONS:New-onset reduction of the LVEF is common in advanced-age patients with NSTEMI and is associated with higher mortality. Treatment with guideline-recommended medications is associated with a better prognosis.


Int J Cardiol


Siddiqui AJ,Holzmann MJ




Has Abstract


2019-12-01 00:00:00












  • Aspirin decreases vascular endothelial growth factor release during myocardial ischemia.

    abstract:BACKGROUND:Vascular Endothelial Growth Factor (VEGF) is an important angiogenesis factor involved in pathophysiology of cardiovascular diseases. Controlling this factor's level in the serum might have significant prognostic outcomes. METHODS:Twenty-four patients undergoing coronary artery bypass grafting were prospect...

    journal_title:International journal of cardiology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Gerrah R,Fogel M,Gilon D

    更新日期:2004-03-01 00:00:00

  • The relation between radionuclide angiography and Doppler echocardiography during contractile changes with infusions of epinephrine.

    abstract::To define the quantitative relations between radionuclide and Doppler measures of systole during sympathetic activation with epinephrine, 10 young normal men were studied with simultaneous radionuclide angiography and M-mode and Doppler echocardiography during graded infusions of epinephrine (10, 25 and 50 ng/kg/min f...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Johannessen KA,Cerqueira M,Veith RC,Stratton JR

    更新日期:1991-10-01 00:00:00

  • Prevalence of risk factors for atrial fibrillation and stroke among 1210 patients with sleep disordered breathing.

    abstract:AIMS:This study sought to identify the prevalence of risk factors for atrial fibrillation and stroke in a sleep apnea population. METHODS:Study participants included 1210 consecutive adults who were referred with suspicion of sleep apnea. Statistical analysis was used to determine the relationship between sleep apnea ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Valenza MC,Baranchuk A,Valenza-Demet G,Muñoz-Casaubon T,Martin-Navajas JA,Healey J

    更新日期:2014-06-01 00:00:00

  • Cardiac tamponade as presentation of systemic amyloidosis.

    abstract::We present a patient with pericardial tamponade due to amyloid heart disease. A 64-yr-old man was admitted to the hospital because of fatigue and the abrupt development of chest pain and dyspnea. Echocardiography showed severe pericardial effusion and total pericardiectomy was necessary. Ten months later laboratory st...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Navarro JF,Rivera M,Ortuño J

    更新日期:1992-07-01 00:00:00

  • Left main coronary artery aneurysm.

    abstract::Left main coronary artery aneurysm is rare finding at coronary angiography. We report a case of a large left main coronary artery aneurysm in a 59-year-old male who had cardiac catheterization for effort angina and inducible myocardial ischemia. ...

    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Gowda RM,Dogan OM,Tejani FH,Khan IA

    更新日期:2005-10-20 00:00:00

  • QT interval prolongation in diphenhydramine toxicity.

    abstract::Diphenhydramine overdose in one of the frequent reported causes of acute poisoning. Patients with diphenhydramine overdose can present with central nervous system manifestations, anticholinergic manifestations and cardiovascular symptoms. The cardiovascular symptoms of diphenhydramine overdose include myocardial depre...

    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Thakur AC,Aslam AK,Aslam AF,Vasavada BC,Sacchi TJ,Khan IA

    更新日期:2005-02-15 00:00:00

  • A validation study of intraoperative performance metrics for training novice cardiac resynchronization therapy implanters.

    abstract:AIMS:Pacing/cardiac resynchronization therapy (CRT) implant training currently lacks a common system to objectively assess trainee ability to perform required tasks at predetermined performance levels. The purpose of this study was to primarily examine construct validity and reliability, secondarily discriminative vali...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Mascheroni J,Mont L,Stockburger M,Patwala A,Retzlaff H,Gallagher AG

    更新日期:2020-05-15 00:00:00

  • Ultrafiltration for acute decompensated heart failure: a systematic review and meta-analysis of randomized controlled trials.

    abstract:BACKGROUND:Current clinical guidelines recommend ultrafiltration (UF) for patients with acute decompensated heart failure (ADHF) who are unresponsive or resistant to diuretics. We systematically reviewed the latest randomized evidence on the efficacy and safety of UF in ADHF. METHODS:MEDLINE, EMBASE and the Cochrane d...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,meta分析,评审


    authors: Kwong JS,Yu CM

    更新日期:2014-03-15 00:00:00

  • Thrombosed mechanical pulmonary valve successfully treated with thrombolysis.

    abstract::Prosthetic heart valve thrombosis is a serious complication with a high mortality. We report the case of a thrombosed St Jude Medical valve placed in the pulmonary position, in a patient who had undergone repair of tetralogy of Fallot, which was successfully treated with intravenous thrombolytic therapy with streptoki...

    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Cid-Cumplido M,Sanchez E,Moya J,Leon R,Dueñas JM,Guerrero R

    更新日期:2007-04-25 00:00:00

  • Early effects of kidney transplantation on the heart - A cardiac magnetic resonance multi-parametric study.

    abstract::Increased native myocardial T1 times in chronic kidney disease (CKD) may be due to diffuse interstitial myocardial fibrosis (DIF) or due to interstitial edema/inflammation. Concerns relating to nephrogenic systemic fibrosis with gadolinium-based contrast agents (GBCA) limit their use in end-stage kidney disease (ESKD)...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Hayer MK,Radhakrishnan A,Price AM,Baig S,Liu B,Ferro CJ,Captur G,Townend JN,Moon JC,Edwards NC,Steeds RP

    更新日期:2019-10-15 00:00:00

  • Comparison of prognostic variables in children and adults with Fontan circulation.

    abstract:BACKGROUND:Non-cardiac complications, such as hepato-renal and metabolic problems, are emerging late after the Fontan operation due to its unique hemodynamics. Consequently, associations between clinical variables and postoperative outcome may change during the prolonged postoperative course. METHODS AND RESULTS:To de...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Ohuchi H,Yasuda K,Miyazaki A,Iwasa T,Sakaguchi H,Shin O,Mizuno M,Negishi J,Noritake K,Yamada O

    更新日期:2014-05-01 00:00:00

  • Effects of dilazep in evolving myocardial infarction in dogs: a biochemical study.

    abstract::Mongrel dogs of either sex with ligation of their left anterior descending coronary artery were employed for the present study to investigate the biochemical basis of the cardioprotective action of dilazep. Dilazep (0.2 mg/kg intravenous) was administered 20 minutes after coronary arterial occlusion. Ligation of the a...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Gupta JB,Seth SD,Singh U,Vyas DS

    更新日期:1989-05-01 00:00:00

  • Atherosclerotic calcification and intimal medial thickness of the carotid arteries.

    abstract:BACKGROUND AND PURPOSE:Carotid intimal medial thickness (IMT) is a measure of subclinical atherosclerosis and is predictive of future cardiovascular events. The purpose of this study was to determine the significance and magnitude of association between IMT and atherosclerotic calcification of the carotid arteries. ME...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Allison MA,Tiefenbrun J,Langer RD,Wright CM

    更新日期:2005-08-03 00:00:00

  • An exploratory analysis of the competing effects of aggressive decongestion and high-dose loop diuretic therapy in the DOSE trial.

    abstract:BACKGROUND:Effective decongestion of heart failure patients predicts improved outcomes, but high dose loop diuretics (HDLD) used to achieve diuresis predict adverse outcomes. In the DOSE trial, randomization to a HDLD intensification strategy (HDLD-strategy) improved diuresis but not outcomes. Our objective was to dete...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Hanberg JS,Tang WHW,Wilson FP,Coca SG,Ahmad T,Brisco MA,Testani JM

    更新日期:2017-08-15 00:00:00

  • Successful percutaneous closure of multiple coronary artery fistulas with coils embolization in two adults.

    abstract::Fistulas between coronary arteries and cardiac cavities or other vascular structures are uncommon findings usually detected early in life. We describe two cases of late transcatheter occlusion of a double coronary artery fistula in adults complaining of incremental dyspnoea. ...

    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Hoffer E,Materne P,Henroteaux D,Markov M,Boland J

    更新日期:2007-11-30 00:00:00

  • Positive cardiac troponin I and T and chest pain in a patient with iatrogenic hypothyroidism and no coronary artery disease.

    abstract::We report about a 41-year old male patient who presented to the emergency room with acute chest pain, exertion dyspnoea, muscle stiffness, myalgia and adynamia. There was no history of coronary artery disease but known arterial hypertension and insulin dependent diabetes mellitus. Four weeks before submission the pati...

    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Buschmann IR,Bondke A,Elgeti T,Kühnle Y,Dietz R,Möckel M

    更新日期:2007-02-07 00:00:00

  • Prognostic characteristics of heart rate recovery according to sex in patients with heart failure.

    abstract::We hypothesized that heart rate recovery (HRR) will provide superior prognostic resolution in female compared to male heart failure (HF) patients. A total of 745 patients with HF underwent exercise testing to determine HRR. While receiver operating characteristic curve analysis revealed HRR prognostic classification s...

    journal_title:International journal of cardiology

    pub_type: 信件,多中心研究


    authors: Arena R,Myers J,Abella J,Pinkstaff S,Peberdy MA,Bensimhon D,Chase P,Guazzi M

    更新日期:2010-11-19 00:00:00

  • New predictors of mortality in adults with congenital heart disease and pulmonary hypertension: Midterm outcome of a prospective study.

    abstract:BACKGROUND:Patients with CHD-PAH have a limited prognosis. In daily practice, combination therapy is often initiated after a clinical event. Although clinical events have been associated with a poor prognosis in idiopathic PAH, data on this association are limited in CHD-PAH. The aim of this study was to determine whet...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Schuuring MJ,van Riel AC,Vis JC,Duffels MG,van Dijk AP,de Bruin-Bon RH,Zwinderman AH,Mulder BJ,Bouma BJ

    更新日期:2015-02-15 00:00:00

  • The association of Mediterranean diet with lower risk of acute coronary syndromes in hypertensive subjects.

    abstract:BACKGROUND:The elevation of blood pressure levels has been recognised as a determinant of the risk for several common cardiovascular diseases. In this work we examined the effect of Mediterranean type of diet on coronary risk in subjects with hypertension. METHODS:CARDIO2000 consisted of 848 randomly selected hospital...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,多中心研究


    authors: Panagiotakos DB,Chrysohoou C,Pitsavos C,Tzioumis K,Papaioannou I,Stefanadis C,Toutouzas P

    更新日期:2002-02-01 00:00:00

  • Left ventricular myocardial performance index in closely-related relatives of patients with dilated cardiomyopathy.

    abstract::In this study, the left ventricular dimensions, systolic function, and left ventricular myocardial performance index in the first-degree relatives of the children with dilated cardiomyopathy (n=19), 30.0+/-17.6 years to normal age- and sex-matched controls (n=25), 27.4+/-17.7 years. The percentage ratio of the measure...

    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Khositseth A,Ausayapao P

    更新日期:2008-03-14 00:00:00

  • Sleep's quality disorders in patients with hypertension and type 2 diabetes mellitus.

    abstract::Sleep is one of the most important factors contributing to health. Although same studies examining the relationship between sleep duration and mortality, has not been fully discussed. We consecutively studied two hundred and fifty Caucasian subjects, normoweight, who were referred for ambulatory blood pressure monitor...

    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Fiorentini A,Valente R,Perciaccante A,Tubani L

    更新日期:2007-01-08 00:00:00

  • Tissue Doppler echocardiographic evidence of atrial mechanical dysfunction in coronary artery disease.

    abstract:BACKGROUND:Atrial function is an integral part of cardiac function which is often neglected. The presence of coronary artery disease (CAD) may impair atrial function. This study investigated if atrial mechanical dysfunction was present in patients with CAD by tissue Doppler echocardiography (TDI). METHODS:Echocardiogr...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Yu CM,Fung JW,Zhang Q,Kum LC,Lin H,Yip GW,Wang M,Sanderson JE

    更新日期:2005-11-02 00:00:00

  • Transvenous pacing in the presence of acute right ventricular infarction.

    abstract::Ventricular tachycardia and ventricular fibrillation are very frequent during transvenous pacing in the presence of acute right ventricular infarction. An acceptable pacing threshold is not usually achieved. A relatively high pacing threshold should, therefore, be accepted in these cases with minimum catheter manipula...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Mittal SR,Mahar MS,Gokhroo RK

    更新日期:1992-01-01 00:00:00

  • A meta-analysis of randomized controlled trials of uninterrupted periprocedural anticoagulation strategy in patients undergoing atrial fibrillation catheter ablation.

    abstract:BACKGROUND:In patients undergoing atrial fibrillation (AF) ablation, despite uninterrupted oral anticoagulants (OACs) have been recommended, no consensus has emerged regarding to whether uninterrupted novel oral anticoagulants (NOACs) are superior to uninterrupted vitamin K antagonists (VKAs) for the periprocedural ant...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,meta分析


    authors: Zhao Y,Lu Y,Qin Y

    更新日期:2018-11-01 00:00:00

  • Clinical profile and outcome of cardiac involvement in MELAS syndrome.

    abstract:BACKGROUND:Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like (MELAS) syndrome is a rare condition with heterogeneous clinical presentation. Cardiac involvement commonly develops during adulthood, comprising both structural and conduction/arrhythmic abnormalities; early paediatric onset has rarely ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Brambilla A,Favilli S,Olivotto I,Calabri GB,Porcedda G,De Simone L,Procopio E,Pasquini E,Donati MA

    更新日期:2019-02-01 00:00:00

  • Anomalous drainage of the right superior vena cava into the left atrium in a 61-year-old woman.

    abstract::This report describes a 61-year-old female with an anomalous drainage of the right superior vena cava into the left atrium. The patient presented progressively severe dyspnea and precordial pain on exertion, lightheadedness, easy fatiguability and a constant decline in her performance but normal cardiac and pulmonary ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审


    authors: Rosenkranz S,Stäblein A,Deutsch HJ,Verhoeven HW,Erdmann E

    更新日期:1998-05-15 00:00:00

  • Do we have a future with transcatheter adventitial delivery of stem cells?

    abstract::Critically evaluating the methodology of the adventitial delivery of stem cells, some specific options should be underlined. Adventitia as the most superficial layer, consisting of connective tissue has to be distinguished of perivascular tissues. By strict definition, an adventitia is the outermost connective tissue ...

    journal_title:International journal of cardiology

    pub_type: 社论


    authors: Kharlamov AN,Duckers HJ,van Beusekom HM,Smits PC,Perin EC,Serruys PW

    更新日期:2013-05-10 00:00:00

  • Endurance training attenuates doxorubicin-induced cardiac oxidative damage in mice.

    abstract:BACKGROUND:There is a lack of studies reporting the influence of DOX treatment on chronically exercised animals. This study intended to determine the effect of endurance swimming training on cardiac muscle tolerance to in vivo DOX-induced damage, analyzing the levels of oxidative stress markers, the response of antioxi...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Ascensão A,Magalhães J,Soares J,Ferreira R,Neuparth M,Marques F,Oliveira J,Duarte J

    更新日期:2005-04-28 00:00:00

  • Extensive exfoliative dermatitis induced by non-ionic contrast medium Iodixanol (Visipaque) used during percutaneous coronary intervention.

    abstract::We report a case of extensive exfoliative dermatitis in a patient appearing 3 days after intracoronary administration of non-ionic contrast medium Iodixanol (Visipaque) during the primary percutaneous coronary intervention. The patient presented with acute myocardial infarction and has never exposed to any X-ray contr...

    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Choi CU,Rha SW,Suh SY,Kim JW,Kim EJ,Park CG,Seo HS,Oh DJ

    更新日期:2008-02-29 00:00:00

  • VGAM induced high-flow congestive heart failure responsive to PGE1 infusion.

    abstract::Vein of Galen Aneurismal Malformation (VGAM), a rare congenital anomaly, can lead to congestive heart failure (CHF) and persistent pulmonary hypertension (PHT). Inotropic drugs, diuretics, mechanical ventilation or inhaled nitric oxide (iNO) are the main therapeutic strategies but often do not suffice to control the s...

    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Karam O,da Cruz E,Rimensberger PC

    更新日期:2009-02-20 00:00:00