Abstract：
BACKGROUND:Targeting the mitochondria during ischemia/reperfusion (IR) can confer cardioprotection leading to improved clinical outcomes. The cardioprotective potential of (-)-epicatechin (EPI) during IR via modulation of mitochondrial function was evaluated. METHODS AND RESULTS:Ischemia was induced in rats via a 45 min occlusion of the left anterior descending coronary artery followed by 1 h, 48 h, or 3 week reperfusion. EPI (10 mg/kg) was administered IV 15 min prior to reperfusion for the single dose group and again 12 h later for the double dose group. Controls received water. Experiments also utilized cultured neonatal rat ventricular myocytes (NRVM) and myoblasts. A single dose of EPI reduced infarct size by 27% at 48 h and 28% at 3 week. Double dose treatment further decreased infarct size by 80% at 48 h, and 52% by 3 weeks. The protective effect of EPI on mitochondrial function was evident after 1h of reperfusion when mitochondria demonstrated less respiratory inhibition, lower mitochondrial Ca2+ load, and a preserved pool of NADH that correlated with higher tissue ATP levels. Mechanistic studies in NRVM revealed that EPI acutely stimulated maximal rates of respiration, an effect that was blocked by inhibitors of the mitochondrial pyruvate carrier, nitric oxide synthase, or soluble guanylyl cyclase. In myoblasts, knockdown of components of the mitochondrial pyruvate carrier blocked EPI-induced respiratory stimulation. CONCLUSIONS:IV EPI confers cardioprotection via preservation of mitochondrial function potentially through enhanced substrate provision. These provocative results document a novel mechanism of a natural product with potential clinical utility.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Yamazaki KG,Andreyev AY,Ortiz-Vilchis P,Petrosyan S,Divakaruni AS,Wiley SE,De La Fuente C,Perkins G,Ceballos G,Villarreal F,Murphy ANdoi
10.1016/j.ijcard.2014.05.009subject
Has Abstractpub_date
2014-08-01 00:00:00pages
297-306issue
2eissn
0167-5273issn
1874-1754pii
S0167-5273(14)00992-9journal_volume
175pub_type
杂志文章abstract：:Myocardial infarct size is one of the most important predictors of prognosis in patients suffering an acute myocardial infarction. It can be assessed by enzymatic and electrocardiographic methods. The present report compares dynamic vectorcardiographic monitoring, serial plasma enzyme activity measurements and QRS sco...
journal_title：International journal of cardiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0167-5273(93)90280-t
更新日期：1993-07-01 00:00:00
abstract：:Revelation of a myocardial bridge has been described at coronary angiography. The pathophysiology of myocardial bridging is incompletely understood. It is sometimes associated with overt pathology, as well as it can just be an incidental finding without any significance. It has been also reported an acute myocardial i...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2007.07.153
更新日期：2009-02-06 00:00:00
abstract：:Atrial fibrillation (AF) is the commonest arrhythmia in clinical practice and is associated with increased cardiovascular morbidity and mortality. Obstructive sleep apnea (OSA), a common breathing disorder, is an independent risk factor for AF. Several pathophysiological mechanisms, including apnea-induced hypoxia, in...
journal_title：International journal of cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.ijcard.2016.12.120
更新日期：2017-03-01 00:00:00
abstract：AIMS:To recapitulate progressive human dilated cardiomyopathy (DCM) and heart block in the Lmna R225X mutant mice model and investigate the molecular basis of LMNA mutation induced cardiac conduction disorders (CD); To investigate the potential interventional impact of exercise endurance. METHODS AND RESULTS:A Lmna R2...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2019.09.058
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:It is unclear whether the cardiac mitochondrial dependent apoptotic pathways and Fas death receptor dependent apoptotic pathways will be induced by long-term intermittent hypoxia. METHODS:Twenty-seven Sprague-Dawley rats were randomly assigned into three groups: normoxia, long-term intermittent hypoxia (12%...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2006.03.064
更新日期：2007-04-04 00:00:00
abstract：BACKGROUND:Advanced heart failure is associated with end-organ damage. Recent literature suggested an intriguing crosstalk between failing heart, abdomen and kidneys. Venous ammonia, as a by-product of the gut, could be a marker of abdominal injury in heart failure patients. The aim of the study was to investigate the ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2015.05.061
更新日期：2015-09-15 00:00:00
abstract：:To determine the effect of functional performance, respiratory function, and osteopenia on the quality of life after heart transplantation. Thirty-one patients were included. Functional performance (peak oxygen consumption - pVO2), respiratory function, quality of life (the short form 36 - SF36) and lumbar spine and h...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2006.12.053
更新日期：2008-03-14 00:00:00
abstract：:To evaluate the effects of chronic smoking on exercise performance we studied 5 smokers and 7 nonsmokers of comparable age and physical characteristics. The resting heart rate in smokers (75 +/- 3 beats/min; mean +/- SD) was significantly (P less than 0.01) higher than in nonsmokers (64 +/- 5). During exercise on a bi...
journal_title：International journal of cardiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0167-5273(86)90034-3
更新日期：1986-06-01 00:00:00
abstract：BACKGROUND:Quantitative flow ratio (QFR) is a novel, adenosine-free method for functional coronary lesion interrogation, which is based on 3-dimensional quantitative coronary angiography and computational algorithms. Data on QFR in all-comer patients with intermediate coronary lesions are scarce, and the diagnostic per...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2018.11.093
更新日期：2019-03-15 00:00:00
abstract：:From June 1977 to February 1986 we studied 31 children with dilated cardiomyopathy. Seven patients (22%) aged 8 months to 3 years had associated congenital cardiac lesions--tetralogy of Fallot (3), coarctation of the aorta (2), ventricular septal defect (1) and Ebstein's malformation (1). The diagnosis was confirmed b...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(87)90035-0
更新日期：1987-10-01 00:00:00
abstract：BACKGROUND:The number and age demographic of the future Fontan population is unknown. METHODS:Population projections were calculated probabilistically using microsimulation. Mortality hazard rates for each Fontan recipient were calculated from survivorship of 1353 Fontan recipients in the Australia and New Zealand Fon...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2016.05.035
更新日期：2016-09-15 00:00:00
abstract：BACKGROUND:This study addresses the impact of availability of on-site catheterization laboratories on the 1-year survival of patients with post-acute myocardial infarction ischemia (P-AMI-I), a high-risk subgroup of AMI patients. METHODS:A prospective 5 month national survey was conducted in 1996 in all operating inte...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/s0167-5273(01)00403-x
更新日期：2001-06-01 00:00:00
abstract：OBJECTIVE:The risk of ischemic stroke, systemic thromboembolism, and all-cause death among heart failure patients previously diagnosed with diabetes mellitus is poorly described. We evaluated the risk of these endpoints among heart failure patients without diagnosed atrial fibrillation according to the presence of diab...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2016.02.004
更新日期：2016-04-15 00:00:00
abstract：OBJECTIVES:Describe quality outcomes of adults with congenital heart disease (ACHD) undergoing cardiovascular procedures and admissions in a free-standing children's hospital with a multi-disciplinary ACHD program and compared with pediatric outcomes. BACKGROUND:A challenge for the U.S. healthcare system is where to t...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2009.07.007
更新日期：2011-02-03 00:00:00
abstract：:Global systolic and diastolic LV function assessed by conventional echocardiographic indices is often normal in patients with controlled hypertension, with or without left ventricular hypertrophy. However, it is not certain whether regional myocardial function in these patients remains normal. We investigated 26 patie...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2005.10.001
更新日期：2006-10-10 00:00:00
abstract：OBJECTIVES:To develop a quantitative event-free prediction model of late atrial arrhythmia after atrial septal defect (ASD) repair. BACKGROUND:The clinical management of ASD is driven by risk factors that determine the occurrence of late atrial arrhythmia. METHODS:Data from ASD type secundum patients, included in the...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2011.07.010
更新日期：2013-04-15 00:00:00
abstract：:Our result supports the reliability of new Anandaraja's formula for low-density lipoprotein estimation in Brazil population. ...
journal_title：International journal of cardiology
pub_type： 评论,信件
doi：10.1016/j.ijcard.2006.07.123
更新日期：2007-07-10 00:00:00
abstract：OBJECTIVE:To evaluate the effect on cardiac hemodynamic parameters of valsartan in patients with chronic stable congestive heart failure previously untreated with ACE inhibitors. METHODS:After a 2 to 4 week run-in period, 116 adult outpatients were randomized to receive valsartan 40, 80 or 160 mg twice daily, the ACE ...
journal_title：International journal of cardiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0167-5273(98)00149-1
更新日期：1998-08-01 00:00:00
abstract：BACKGROUND:Multi-antibiotic resistance in bacterial infections is a growing threat to public health. Some experiments were carried out to study the multi-antibiotic resistance. METHODS:The changes of the multi-antibiotic resistance with time were achieved by numerical simulations and the mathematical models, with the ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2016.05.069
更新日期：2016-09-15 00:00:00
abstract：OBJECTIVE:To compare the prevalence of type 2 diabetes mellitus (DM) and coronary artery disease (CAD) and hypertension in DM in the rural and urban populations of north India. DESIGN AND METHODS:Two populations of the same ethnic background were randomly selected for this cross sectional survey. There were 1769 rural...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/s0167-5273(98)00141-7
更新日期：1998-09-01 00:00:00
abstract：BACKGROUND:The associations between autonomic function and biventricular function in patients with the indeterminate form of Chagas disease remains to be elucidated. METHODS:In 42 asymptomatic patients and 19 healthy volunteers, the autonomic function was assessed by time domain indices of heart rate variability (HRV)...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2005.11.010
更新日期：2006-11-10 00:00:00
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journal_title：International journal of cardiology
pub_type： 杂志文章,多中心研究
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更新日期：2017-11-01 00:00:00
abstract：:We sought to investigate the potential impact of obesity on left ventricular (LV) systolic function in patients with hypertension and normal ejection fraction (EF). In 112 hypertensive subjects with echocardiographic evidence of normal EF, M-mode left atrio-ventricular plane displacement, and Tissue Doppler-derived pe...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2008.11.129
更新日期：2010-06-11 00:00:00
abstract：:Over a period of 12 years, two cases of pulmonary arterial aneurysms were encountered in our autopsy data of 13 cases of congenital heart defects with right-sided infective endocarditis. Pulmonary arterial aneurysms are rare lesions and may be categorized as central or peripheral. Although early reports implicated tub...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(92)90247-z
更新日期：1992-06-01 00:00:00
abstract：:A 66-year-old man presented with myocardial infarction. Chest X-ray showed a large mediastinal mass. Aortic dissection was suggested by a past history of chest trauma, but the mass was in a very atypical site. Dissection of an abnormally placed right-sided descending aorta was confirmed by computed tomography. The aor...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(88)90174-x
更新日期：1988-02-01 00:00:00
abstract：:Forty asymptomatic patients were studied after a first uncomplicated myocardial infarction. They were 36 men and 4 women, with a mean age of 52.6 yr; the location of myocardial infarction was in the anterior wall in 18 (45%) patients and in the inferior wall in 22 (55%). The patients were submitted to: (1) 48-h Holter...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(93)90202-r
更新日期：1993-01-01 00:00:00
abstract：:We have studied in a normal animal model (sheep), the biochemical and morphological adaptation of electrically stimulated skeletal muscle used for extra aortic counterpulsation. Immunocytochemical analysis of latissimus dorsi, using monoclonal antibodies to slow and fast myosin heavy chains, indicated an increase in t...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(91)90093-5
更新日期：1991-02-01 00:00:00
abstract：:Left main coronary artery (LMCA) disease is now uniformly treated with coronary artery bypass grafting (CABG). However, some patients with LMCA disease do not receive CABG because of high operative risks. The advent of stent implantation has permitted a non-operative improvement in myocardial blood flow in many patien...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/s0167-5273(01)00478-8
更新日期：2001-09-01 00:00:00
abstract：:The pathogenesis of double outlet right ventricle with or without pulmonary infundibular atresia in mouse fetal trisomy 13 was studied at the organ level using microdissection and scanning electron microscopy. Altogether, 394 karyotyped trisomic embryos were collected between 11 days and 16 hours of gestation (presenc...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(91)90359-w
更新日期：1991-11-01 00:00:00
abstract：BACKGROUND:Contrast-enhanced cardiac magnetic resonance imaging (MRI) can depict papillary muscle (PM) necrosis or fibrosis by late enhancement (LE) of PM, but its clinical significance in old myocardial infarction (OMI) has been little understood. METHODS:Myocardial LE and PM-LE were detected with contrast imaging in...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2010.04.037
更新日期：2011-01-07 00:00:00
