Abstract:
OBJECTIVES:To develop a quantitative event-free prediction model of late atrial arrhythmia after atrial septal defect (ASD) repair. BACKGROUND:The clinical management of ASD is driven by risk factors that determine the occurrence of late atrial arrhythmia. METHODS:Data from ASD type secundum patients, included in the Belgian Congenital Heart Disease Registry, were analyzed. Based on review of the literature, age at repair, gender, pulmonary hypertension, atrial arrhythmia before and within one month after repair were included in the model. Using Cox-regression analysis, a weighted risk score was derived, which was validated using the Brier score. RESULTS:A total of 155 patients (117 women; median age at follow-up 53.9 years, range 18.0-78.8) having 349 follow-up years was included. Thirty-nine patients (25.2%) presented with late atrial arrhythmia. Multivariate analysis showed that a mPAP ≥ 25 mmHg (HR 4.39; 95%CI 2.17-9.09; P<0.0001), the presence of atrial arrhythmia before (HR 3.52; 95%CI 1.75-7.14; P=0.002) and ≤ 1month after repair (HR 6.62; 95%CI 2.38-20.00; P<0.0001) and gender (HR 2.18 95%CI 1.11-4.35) were associated with late atrial arrhythmia. A risk score (0 to 28 points) to predict atrial arrhythmia free survival was derived for follow-up times ranging from one to 5 years. Mean Brier score for the model was 0.10. CONCLUSIONS:We formulated a well validated risk model to predict arrhythmia-free survival in ASD patients undergoing ASD repair. Further research is needed whether this model can be used for individual clinical risk stratification and whether the model can be adapted for application in other congenital heart defects.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Van De Bruaene A,Moons P,Belmans A,Post MC,Luermans JG,Delcroix M,Pasquet A,De Backer J,Paelinck B,Morissens M,Budts Wdoi
10.1016/j.ijcard.2011.07.010subject
Has Abstractpub_date
2013-04-15 00:00:00pages
318-22issue
3eissn
0167-5273issn
1874-1754pii
S0167-5273(11)00696-6journal_volume
164pub_type
杂志文章abstract:BACKGROUND:The prognostic value of circulating oxidized low-density lipoprotein (OxLDL) in patients with unstable coronary artery disease (CAD) is unknown. METHODS:Plasma levels of OxLDL were measured in 433 patients with unstable CAD included in FRISC-II (Fragmin and fast Revascularisation in Instability in Coronary ...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:International journal of cardiology
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2013-10-03 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,评审
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journal_title:International journal of cardiology
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更新日期:2018-11-15 00:00:00
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journal_title:International journal of cardiology
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更新日期:1991-03-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2009.02.017
更新日期:2011-05-05 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2007-01-02 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2013-12-10 00:00:00
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更新日期:1985-09-01 00:00:00
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journal_title:International journal of cardiology
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更新日期:2015-03-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2015-02-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2013-09-10 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:1989-01-01 00:00:00
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更新日期:2017-01-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
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更新日期:2017-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-04-30 00:00:00