Abstract:
BACKGROUND:Timing of surgery for mitral regurgitation (MR) is one of the more difficult decisions for the practicing cardiologist. METHODS AND RESULTS:In order to determine useful clinical cut-offs, we investigated the influence of baseline echocardiographic predictors for survival in a long-time follow-up cohort. Data from 144 patients with MR were collected between 1989 and 1993. Five-year mortality for MR patients was 30% compared to 13% for age- and sex matched controls (p<0.001). Each mm increase in left ventricular end systolic diameter (LVESD increased mortality with 2.5% (p<0.05) and each percent decrease in ejection fraction (EF) increased mortality with 1.8% (p<0.05). These effects were not linear and this material suggests cut-off points for LVESD to be 40 mm and EF 50%. Degree of MR did not correlate with survival, but patients with severe MR were operated more often than those with moderate MR. Patients with functional MR had reduced survival compared to patients with structural MR (p<0.01). CONCLUSIONS:MR is a disease with greatly increased mortality and these data suggest a more aggressive approach to surgery.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Lindmark K,Söderberg S,Teien D,Näslund Udoi
10.1016/j.ijcard.2008.06.037subject
Has Abstractpub_date
2009-10-02 00:00:00pages
145-50issue
2eissn
0167-5273issn
1874-1754pii
S0167-5273(08)00834-6journal_volume
137pub_type
杂志文章abstract:OBJECTIVE:To analyze whether left ventricular dyssynchrony (LVD) at baseline is predictive for long-term outcome in heart failure (CHF) patients with left ventricular (LV) dysfunction and conduction disturbances treated with cardiac resynchronization therapy (CRT). METHODS:In 535 consecutive individuals with CHF sched...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2013.06.060
更新日期:2013-10-09 00:00:00
abstract::The noninvasive assessment of the mechanisms that lead to left ventricular outflow obstruction in hypertrophic cardiomyopathy allows the correct clinical management and the most suitable medical or surgical treatment for these patients. We report the case of a male patient affected by hypertrophic obstructive cardiomy...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.04.154
更新日期:2007-09-14 00:00:00
abstract:BACKGROUND AND PURPOSE:Underuse of anticoagulants in ischemic stroke patients with atrial fibrillation (AF) and/or rheumatic heart disease (RHD) is a global concern, especially in China. However, the extent to which anticoagulants are underused in AF and/or RHD-related ischemic stroke in China has not been well charact...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2020.08.046
更新日期:2021-01-01 00:00:00
abstract::Serial changes in thromboxane B2, a stable catabolite of thromboxane A2, were measured by radioimmunoassay in peripheral plasma of 55 patients with acute myocardial infarction. Twenty two of 31 patients who were admitted within 6 hr after the onset of acute myocardial infarction, exhibited high thromboxane B2 levels (...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(85)90222-0
更新日期:1985-07-01 00:00:00
abstract:INTRODUCTION:Accurate predictors of good clinical response after MitraClip implant in patients with heart failure (HF) are still lacking. Aim of this study was to investigate the role of regurgitant fraction >50% as a marker of disproportionate functional mitral regurgitation (FMR) in identifying best responders to Mit...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2020.08.026
更新日期:2021-01-15 00:00:00
abstract:BACKGROUND:Patent foramen ovale (PFO) closure after a cryptogenic cerebral ischemic event is a routinely procedure. The most used device is Amplatzer™ PFO Occluder 25 mm, but PFOs with complex anatomy require larger device for closure. We compared Amplatzer™ Septal Occluder (ASO) device versus Amplatzer™ PFO Occluder 3...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.10.053
更新日期:2019-03-15 00:00:00
abstract:BACKGROUND:Blood pressure (BP) control has been shown to reduce the risk of heart failure (HF) among diabetic patients; however, it is not known whether the lowest clinical BP achieved ultimately results in the lowest risk of HF in diabetic patients. METHODS:We performed a prospective cohort study which included 17,18...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2014.06.051
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Vascular Endothelial Growth Factor (VEGF) is an important angiogenesis factor involved in pathophysiology of cardiovascular diseases. Controlling this factor's level in the serum might have significant prognostic outcomes. METHODS:Twenty-four patients undergoing coronary artery bypass grafting were prospect...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.ijcard.2003.03.007
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Traditional risk factors for cardiovascular disease (CVD) have been thoroughly investigated. We aimed to investigate the impact of comorbid cardiovascular risk factors and diseases on length of stay (LOS) and mortality in patients presenting with acute coronary syndromes (ACS). METHODS:We examined prevalenc...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2016.06.188
更新日期:2016-10-01 00:00:00
abstract::We studied 13 patients with sick sinus syndrome using various physical (postural reflex testing. Valsalva manoeuvre, carotid sinus massage), pharmacological (intravenous isoprenaline, atropine, neostigmine and total autonomic blockade) and electrophysiological tests in order to identify simple non-invasive markers of ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(86)90243-3
更新日期:1986-08-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:The aim of this study was to develop a myocardial bioprosthesis for cardiac repair with an integrated online monitoring system. Myocardial infarction (MI) causes irreversible myocyte loss and scar formation. Tissue engineering to reduce myocardial scar size has been tested with variable success, y...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.04.181
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Ischaemic heart disease (IHD) is the leading cause of death worldwide. The World Health Organisation (WHO) collects mortality data coded using the International Statistical Classification of Diseases (ICD) code. METHODS:We analysed IHD deaths world-wide between 1995 and 2009 and used the UN population datab...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2012.10.046
更新日期:2013-09-30 00:00:00
abstract::Seventy-eight patients undergoing mitral valve surgery with or without replacement of the aortic valve also underwent procedures on the tricuspid valve over a period of 10 years. All patients were in functional class III or IV preoperatively. The procedures were performed in all patients with organic disease of the tr...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(89)90324-0
更新日期:1989-04-01 00:00:00
abstract:OBJECTIVE:To investigate whether more benefits can be achieved through high intensity atorvastatin compared with moderate intensity atorvastatin in acute coronary syndrome (ACS) patients with diabetes mellitus (DM). METHODS:This was a randomized controlled trail. Total 591 ACS patients with DM who underwent percutaneo...
journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijcard.2016.07.140
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Targeting the mitochondria during ischemia/reperfusion (IR) can confer cardioprotection leading to improved clinical outcomes. The cardioprotective potential of (-)-epicatechin (EPI) during IR via modulation of mitochondrial function was evaluated. METHODS AND RESULTS:Ischemia was induced in rats via a 45 m...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.05.009
更新日期:2014-08-01 00:00:00
abstract::A case report is described of a patient presenting with extrapericardial cardiac compression resulting from massive ascites. The history and electrocardiographic findings initially obscured the proper diagnosis. Extrapericardial cardiac compression syndromes resulting from massive ascites pose a particular challenge i...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2005.09.037
更新日期:2006-11-10 00:00:00
abstract:BACKGROUND:Guanosine is a natural product and an endogenous nucleoside that has shown to increase during myocardial ischemia. Platelets are critically involved in ischemic coronary events. It remains unknown, however, whether guanosine may affect platelet activation and function. We sought to investigate the potential ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.08.006
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:To estimate the influence of therapy with amlodipine (A) or lacidipine (L) on heart rate variability (HRV) time and frequency domain parameters in hypertensive patients with stable angina pectoris and isolated left ventricular diastolic dysfunction. METHODS:After a 1-week washout period, the patients were ra...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.ijcard.2004.03.040
更新日期:2005-06-08 00:00:00
abstract:INTRODUCTION:A number of challenges can affect long-term performance of endocardial implanted systems in pediatric patients. Select Secure™ lead offers potential advantages for this population. This analysis aims to evaluate long-term performance of this lead in children, with and without congenital heart disease. MET...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.01.007
更新日期:2018-03-15 00:00:00
abstract::Autoimmune polyglandular syndromes (APS) consist of the failure of two or more endocrinal glands together requiring hormone replacement. Type II APS, first described by Schmidt in 1926, is the commonest type of APS. In majority of patients, type II APS consists of Addison's disease in combination with autoimmune thyro...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2009.03.020
更新日期:2011-05-19 00:00:00
abstract:BACKGROUND:Sixty-four-slice multidetector spiral computed tomography (CT) has improved temporal resolution and reduced acquisition time. We aimed to evaluate the functional analysis using 64-slice CT comparing with echocardiography, electrocardiographically gated single-photon emission tomography (SPECT) and cardiovasc...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2007.06.017
更新日期:2008-08-01 00:00:00
abstract::Pulse wave analysis (PWA) by radial arterial tonometry is receiving increasing attention for the assessment of central vascular compliance in younger patients. We present five PWA studies performed prospectively on a patient with severe coronary artery disease, and find that the measures of central augmented pressure ...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2009.03.015
更新日期:2011-05-19 00:00:00
abstract::With the advent of transesophageal echocardiography (TEE), thrombi of the aorta are becoming increasingly recognized as possible sources of systemic emboli. This report describes a 58-year-old woman with multiple unexplained peripheral emboli. A giant thrombus of the descending aorta has been identified as the source ...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/s0167-5273(02)00509-0
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND:Hypertension is an important risk factor for cardiovascular diseases. Pathophysiology and molecular mechanisms involved in hypertension regulation are not very well known. Recently, high-throughput Next-Generation Sequencing (NGS) technology has identified hundreds of gene loci associated with multiple cardi...
journal_title:International journal of cardiology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.ijcard.2016.11.179
更新日期:2017-02-01 00:00:00
abstract::To evaluate the effects of inotropic stimulation on ventriculo-arterial coupling, we determined both the slope of the end-systolic pressure-volume relationship (ventricular elastance) and the slope of end-systolic pressure-stroke volume relationship (arterial elastance) at rest and during dobutamine infusion (5 microg...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(91)90267-s
更新日期:1991-04-01 00:00:00
abstract:BACKGROUND:The involvement of iron in anthracycline cardiotoxicity is supported by extensive experimental data, and by the preventive efficacy of dexrazoxane, an iron chelator. However, no clinical evidence of anthracycline-induced cardiac iron accumulation is available and the influence of previous iron overload or of...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2010.09.046
更新日期:2012-02-09 00:00:00
abstract:BACKGROUND:Chronic kidney disease (CKD) is associated with worse survival in patients with implantable cardiac defibrillators (ICDs). This study examined the association of outcomes with CKD in patients receiving an ICD for primary versus secondary prevention. METHODS:The study included 696 patients who underwent ICD ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2011.07.087
更新日期:2013-04-30 00:00:00
abstract:BACKGROUND:The trends in the IHD mortality rates vary widely across countries, reflecting the heterogeneity in the variation of the exposure to the main risk factors and in the access to different management strategies among settings. We aimed to identify model-based patterns in the time trends in IHD mortality in 50 c...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2013.11.004
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Beraprost sodium, an orally active prostacyclin analogue, has proved to be beneficial for the patients with primary pulmonary hypertension and obstructive peripheral arterial disease. METHODS:In this study, we examined the effects of BPS on the expression of the VEGF and PAI-1 genes in vascular smooth muscl...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2007.12.119
更新日期:2009-03-06 00:00:00
abstract::We report a case of isolated prolapse of the tricuspid valve producing gross incompetence as documented by Doppler examination. This case shows that hemodynamically significant tricuspid regurgitation can occur from isolated prolapse of valvar leaflets. ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(90)90277-c
更新日期:1990-10-01 00:00:00