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The beneficial effects of angiotensin-converting enzyme inhibitors on serum asymmetric dimethylarginine levels in the patients with cardiovascular disease.

Abstract：

:ACEI and AT1 receptor antagonists are the drugs most consistently shown to reduce ADMA level in humans. Unfortunately, most of the human studies addressing the effect of pharmacotherapy on ADMA metabolism were accomplished on small patient subgroups and were relatively shortlasting. Besides, L-arginine was rarely measured in most studies, whereas L-arginine/ADMA ratio may be more important for NO synthase function than ADMA itself, and arginine concentration may be either increased or decreased by pharmacotherapy. We strongly believe that agents affecting ADMA more specifically (protein arginine methyltransferases inhibitors or dimethylarginine dimethylaminohydrolase inducers) deserve further investigation.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Celik T,Iyisoy A,Yuksel C,Jata B

doi

10.1016/j.ijcard.2008.11.109

subject

Has Abstract

pub_date

2010-06-25 00:00:00

pages

107-9

issue

1

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(08)01310-7

journal_volume

142

pub_type

信件

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