Abstract:
OBJECTIVES:This study tests the hypothesis that circulating mononuclear cells expressing osteocalcin (OCN) and bone alkaline phosphatase (BAP) are associated with distinct plaque tissue components in patients with early coronary atherosclerosis. BACKGROUND:Plaque characteristics implying vulnerability develop at the earliest stage of coronary atherosclerosis. Increasing evidence indicates that cells from the myeloid lineage might serve as important mediators of destabilization. Plaque burden and its components were assessed regarding their relationship to monocytes carrying both pro-inflammatory (CD14) and osteogenic surface markers OCN and BAP. METHODS:Twenty-three patients with angiographically non-obstructive coronary artery disease underwent coronary endothelial function assessment and virtual histology-intravascular ultrasound of the left coronary artery. Plaque composition was characterized in the total segment (TS) and in the target lesion (TL) containing the highest amount of plaque burden. Blood samples were collected simultaneously from the aorta and the coronary sinus. Circulating cell counts were then identified from each sample and a gradient across the coronary circulation was determined. RESULTS:Circulating CD14+/BAP+/OCN+ monocytes correlate with the extent of necrotic core and calcification (r=0.53, p=0.010; r=0.55, p=0.006, respectively). Importantly, coronary retention of CD14+/OCN+ cells also correlates with the amount of necrotic core and calcification (r=0.61, p=0.003; r=0.61, p=0.003) respectively. CONCLUSIONS:Our study links CD14+/BAP+/OCN+ monocytes to the pathologic remodeling of the coronary circulation and therefore associates these cells with plaque destabilization in patients with early coronary atherosclerosis.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Collin J,Gössl M,Matsuo Y,Cilluffo RR,Flammer AJ,Loeffler D,Lennon RJ,Simari RD,Spoon DB,Erbel R,Lerman LO,Khosla S,Lerman Adoi
10.1016/j.ijcard.2014.11.156subject
Has Abstractpub_date
2015-02-15 00:00:00pages
57-64eissn
0167-5273issn
1874-1754pii
S0167-5273(14)02328-6journal_volume
181pub_type
杂志文章abstract:BACKGROUND:Myocardial bridge (MB) has been reported to induce cardiac complications including coronary vasospasm. Although MB has some anatomical and morphological variations, the association of these variations with vasospasm is unclear. The aim of this study was to investigate the relation between morphological sever...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.07.002
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:Angiotensin-converting enzyme inhibitor (ACEI) is beneficial in patients with congestive heart failure (CHF). Some, but not all, angiotensin receptor blocker (ARB) was demonstrated to be effective as "add-on" therapy. We investigated whether irbesartan is useful as an add-on therapy in CHF. DESIGN:Randomized...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.ijcard.2007.02.016
更新日期:2008-03-28 00:00:00
abstract::Critically evaluating the methodology of the adventitial delivery of stem cells, some specific options should be underlined. Adventitia as the most superficial layer, consisting of connective tissue has to be distinguished of perivascular tissues. By strict definition, an adventitia is the outermost connective tissue ...
journal_title:International journal of cardiology
pub_type: 社论
doi:10.1016/j.ijcard.2012.11.063
更新日期:2013-05-10 00:00:00
abstract::Although high risk and low risk profile for thrombo-embolic events have been extensively and intensively investigated in multi-centre trials and described in detail in atrial fibrillation guidelines, the management of those at otherwise intermediate risk is still a 'no-one's zone'. Individual risk profile is mandatory...
journal_title:International journal of cardiology
pub_type: 评论,信件
doi:10.1016/j.ijcard.2007.01.056
更新日期:2008-03-14 00:00:00
abstract::Common arterial trunk is a rare congenital anomaly, usually found in the setting of a concordant atrioventricular connexion. The association of a common arterial trunk with absence of the right atrioventricular connexion is very rare, having, as far as we know, been reported only twice in the literature. In the case r...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(90)90298-j
更新日期:1990-06-01 00:00:00
abstract::This study was performed to evaluate whether transoesophageal atrial pacing could also stop ventricular tachycardias with low rates and no haemodynamic impairment. Prior to resorting to ventricular endocardial pacing, seven male patients, aged between 15 and 73 years, were treated by transoesophageal atrial pacing for...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(90)90318-y
更新日期:1990-09-01 00:00:00
abstract:BACKGROUND:Inflammation and oxidative stress play a crucial role in the pathogenesis of cardiac sarcoidosis (SAR). We investigated whether urinary (U) 8-hydroxy-2'-deoxyguanosine (8-OHdG)--an oxidative DNA damage marker--was related to SAR inflammatory activity. METHODS:U-8-OHdG levels were measured in 31 SAR patients...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2015.04.144
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abstract::The differentiation of viable from non viable myocardium is a key issue in the current era of revascularization. Several methods have been used to assess myocardial viability. The radionuclide detection of dysfunctional but viable myocardium depends upon the use of radiotracers whose uptake and trapping are related to...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(98)00066-7
更新日期:1998-05-29 00:00:00
abstract:BACKGROUND:Myocardial infarct size (IS) following ST-segment elevation myocardial infarction (STEMI) is an important prognostic factor. We assessed the Selvester 32-point QRS score from the 12-lead ECG for measurement of IS in STEMI patients receiving reperfusion therapy compared to cardiac magnetic resonance imaging (...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.06.171
更新日期:2016-10-01 00:00:00
abstract::Separate origin of the left anterior descending and circumflex coronary artery from the left sinus of Valsalva is one of the most frequent benign coronary artery anomalies. We hereby report, for the first time, a case of sudden death in a young man with this anomaly. The clinicopathologic findings and the possible pat...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.08.124
更新日期:2009-03-20 00:00:00
abstract:PURPOSE:Aortic valve dysfunction is common in coarctation patients(CoA). Bicuspid aortic valve (BAV) in CoA is associated with aortic valve stenosis (AS), aortic valve regurgitation (AR), and ascending aortic dilatation. The aim of this study was to evaluate the progression of and predictors for aortic valve dysfunctio...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2012.07.028
更新日期:2013-09-10 00:00:00
abstract:BACKGROUND:Recently, stent fracture (SF) of sirolimus-eluting stents (SES) has been shown to be associated with an increased risk of in-stent restenosis. We sought to evaluate the incidence, predictors and clinical outcome of SF after SES implantation in comparable unselected lesions. METHODS:A total of 430 lesions of...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2007.12.067
更新日期:2009-04-17 00:00:00
abstract:BACKGROUND:Recent evidence indicates that epicardial adipose tissue (EAT) expresses uncoupling protein-1 (UCP1), a marker of brown adipocytes. However, the putative effects of the presence of brown adipocytes in EAT remain unknown. METHODS:The mRNA expression of genes related to brown adipocyte-mediated thermogenesis ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2012.06.008
更新日期:2013-09-01 00:00:00
abstract::The purpose of this study was to examine the value of marked left axis deviation in men without apparent heart disease in the assessment of ischemic heart disease risk. In the Manitoba Study, a cohort of 3983 men who were predominantly between 25 to 34 yr of age at entry in 1948, 247 cases of marked left axis deviatio...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(81)90030-9
更新日期:1981-01-01 00:00:00
abstract::A 44-year-old woman with hypertension was admitted because of recent onset chest pain. Coronary angiography revealed an anomalous right coronary artery originating as a separate branch from the left anterior descending artery. Associated with the present case all published case reports were thoroughly investigated and...
journal_title:International journal of cardiology
pub_type: 信件,评审
doi:10.1016/j.ijcard.2007.04.121
更新日期:2008-07-04 00:00:00
abstract::Isolated noncompaction of the ventricular myocardium (INVM) is an unclassified cardiomyopathy and is thought to be due to arrest of myocardial morphogenesis. Left ventricular failure and ventricular arrhythmias may occur in approximately half of the patients and account for half of the death in this disorder. In this ...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2008.05.022
更新日期:2009-08-21 00:00:00
abstract::We describe a case of fatal reaction to angiocardiography following investigation of tetralogy of Fallot. This happening has occurred only once in 8300 procedures in our laboratory. It was due to cerebral edema. Although a recognized, but very rare, hazard following injection of contrast material, we found no way in o...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(85)90127-5
更新日期:1985-08-01 00:00:00
abstract:BACKGROUND:There is a lack of studies reporting the influence of DOX treatment on chronically exercised animals. This study intended to determine the effect of endurance swimming training on cardiac muscle tolerance to in vivo DOX-induced damage, analyzing the levels of oxidative stress markers, the response of antioxi...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2004.11.004
更新日期:2005-04-28 00:00:00
abstract:OBJECTIVE:To study if the coexistence of chronic obstructive pulmonary disease (COPD) in patients diagnosed with acute heart failure (AHF) at the emergency department (ED) has an impact on short- and long-term outcomes. METHOD:The EAHFE-COPD study included patients who attended in 34 Spanish EDs for AHF. We compared p...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.11.013
更新日期:2017-01-15 00:00:00
abstract:RATIONALE:Pressure overload induces adaptive remodeling processes in the heart. However, when pressure overload persists, adaptive changes turn into maladaptive alterations leading to cardiac hypertrophy and heart failure. ATF3 is a stress inducible transcription factor that is transiently expressed following neuroendo...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2015.06.099
更新日期:2015-11-01 00:00:00
abstract::The aim of this study, using right ventricular endomyocardial biopsies, was to determine whether adenylyl cyclase activity is decreased-despite cardiac denervation-in human failing transplanted myocardium. beta-Adrenoceptor-stimulated adenylyl cyclase activity in membranes of moderately failing transplanted hearts was...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(96)02709-x
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:A method to objectively detect in-stent restenosis (ISR) with multi-slice computed tomography (MSCT) has not been established yet. We aimed to evaluate the usefulness of measuring coronary lumen density with MSCT to detect ISR. METHODS:Forty-seven coronary stented lesions in 38 patients were evaluated with ...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2006.11.231
更新日期:2008-02-29 00:00:00
abstract:BACKGROUND:Approximately 40% of patients with heart failure have preserved left ventricular systolic function with latent diastolic dysfunction associated with left ventricular hypertrophy, suggesting that diastolic dysfunction participates in the pathophysiology of heart failure. However, the cause or prerequisite sta...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2006.07.004
更新日期:2007-05-16 00:00:00
abstract:AIM:To assess whether 24-h ambulatory ECG (AECG) recording underestimates arrhythmic risk in subjects with both ventricular ectopy and cardiovascular risk factors or history of coronary heart disease (CHD). METHODS:29 consecutive patients with both ECG evidence of premature ventricular contractions (PVCs) and cardiova...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.02.055
更新日期:2008-07-04 00:00:00
abstract:BACKGROUND:This study sought to examine a possible relationship between the severity of aortic valve calcification (AVC), the distribution of AVC and the degree of aortic valve regurgitation (AR) after transcatheter aortic valve implantation (TAVI) for severe aortic stenosis (AS). METHODS:57 patients (22 men, 81 ± 5 y...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2010.03.004
更新日期:2011-07-15 00:00:00
abstract::We report on a case of a fatal pulmonary embolism--an unexpected finding at autopsy of a 71-year-old man who had suffered from severe erosive gouty arthritis. Using morphological findings, medical history and histopathological results, we show the potentially devastating complications of this fairly common medical con...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2005.11.093
更新日期:2007-01-18 00:00:00
abstract::We sought to investigate the potential impact of obesity on left ventricular (LV) systolic function in patients with hypertension and normal ejection fraction (EF). In 112 hypertensive subjects with echocardiographic evidence of normal EF, M-mode left atrio-ventricular plane displacement, and Tissue Doppler-derived pe...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2008.11.129
更新日期:2010-06-11 00:00:00
abstract:BACKGROUND:Currently available ventricular assist devices are designed primarily for use in patients with left sided heart failure. This study evaluated the efficacy of the Jarvik 2000 ventricular assist device (VAD) as a pulmonary pump to power a Fontan circuit in a large animal model. METHODS:Without the use of card...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.08.012
更新日期:2014-10-20 00:00:00
abstract:BACKGROUND:Guideline-recommended beta-blocker (BB) target doses for patients with chronic heart failure can often not be reached. This secondary analysis of the CIBIS-ELD trial was carried out to better understand reasons for not achieving target doses. METHODS:Changes in heart rate (HR) and other parameters during a ...
journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijcard.2011.11.018
更新日期:2012-02-23 00:00:00
abstract:BACKGROUND:Aortic stenosis (AS) poses a perioperative management dilemma to physicians looking after patients who require non-cardiac surgery. The objective of this review is to investigate mortality and adverse cardiovascular events in patients with and without AS who underwent non-cardiac surgery. METHODS:We searche...
journal_title:International journal of cardiology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.ijcard.2017.04.037
更新日期:2017-08-01 00:00:00