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Therapeutic options of Angiotensin Receptor Neprilysin inhibitors (ARNis) in chronic heart failure with reduced ejection fraction: Beyond RAAS and sympathetic nervous system inhibition.

Abstract：

:In heart failure, in addition to the renin-angiotensin-aldosterone system and sympathetic nervous system, the natriuretic peptide (NP) system plays a fundamental role among compensating mechanisms. The NPs undergo rapid enzymatic degradation that limits their vasorelaxant, natriuretic, and diuretic actions. Degradation of NPs is partially due to the action of neprilysin, which is a membrane-bound endopeptidase found in many tissues. This article summarizes recent findings on a new natriuretic peptide-enhancing drug and their implication for future pharmacological treatment of patients suffering from heart failure with reduced ejection fraction.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Volterrani M,Iellamo F,Senni M,Piepoli MF

doi

10.1016/j.ijcard.2016.04.180

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

132-135

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(16)30876-2

journal_volume

226

pub_type

杂志文章,评审

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