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A novel haplotype in ApoAI-CIII-AIV gene region is detrimental to Northwest Indians with coronary heart disease.

Abstract：

:The present study investigated the genetic variation of 3' flanking region of ApoA-I (PstI), 3' untranslated region of ApoC-III (SstI) and intron 2 of ApoA-IV (XbaI) in 193 angiographically diagnosed CHD patients and 150 CHD negative controls of Punjab, Northwest India. Haplotype analysis reveals that P2-S2-X1 is a susceptibility haplotype that confers the risk of CHD (OR 2.33, CI 1.08-4.38, P<0.05), which exacerbates (OR 2.61, CI 1.23-5.92, P<0.01) after adjustment with the confounders. This exacerbating effect of P2-S2-X1 may umpire significant higher levels of TG, LDL/HDL ratio and lower levels of HDL in CHD patients.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Singh P,Singh M,Kaur TP,Grewal SS

doi

10.1016/j.ijcard.2007.07.029

subject

Has Abstract

pub_date

2008-11-28 00:00:00

pages

e93-5

issue

3

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(07)01489-1

journal_volume

130

pub_type

信件

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