Abstract：
:Mongrel dogs of either sex with ligation of their left anterior descending coronary artery were employed for the present study to investigate the biochemical basis of the cardioprotective action of dilazep. Dilazep (0.2 mg/kg intravenous) was administered 20 minutes after coronary arterial occlusion. Ligation of the artery for 40 minutes increased the tissue lactate concentration and decreased the adenosine triphosphate molecules within the occluded bed. Dilazep decreased the lactate concentration and improved the adenosine triphosphate content of this bed significantly. Dilazep also lowered the tissue cyclic adenosine monophosphate concentration and free fatty acid extraction of the ischemic myocardium as studied 40 minutes after coronary arterial ligation. It can be inferred that less free fatty acid extraction and calcium antagonistic action of dilazep helps in restoring mitochondrial function. Furthermore, decreased tissue lactate concentration resulted after better perfusion of the occluded bed and helped in greater generation of adenosine triphosphate molecules. These favorable biochemical and metabolic changes contribute to the cardioprotective action of dilazep.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Gupta JB,Seth SD,Singh U,Vyas DSdoi
10.1016/0167-5273(89)90244-1subject
Has Abstractpub_date
1989-05-01 00:00:00pages
165-71issue
2eissn
0167-5273issn
1874-1754pii
0167-5273(89)90244-1journal_volume
23pub_type
杂志文章abstract：:In 29 patients with stable ischaemic heart disease, right heart catheterization was performed to assess the effect of exercise and nitroglycerin on right ventricular volumes, which were determined by a new computerized thermodilution system. The coefficient of variation for the determination of right ventricular eject...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(91)90149-j
更新日期：1991-10-01 00:00:00
abstract：:Atrial septal defect (ASD) accounts for approximately a third of all congenital heart disease in adults. It is rarely diagnosed and less likely to cause any symptoms during infancy, but approximately more than half become symptomatic around their fifth decade. In clinical setting it commonly presents as exertional dys...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2008.12.039
更新日期：2010-08-20 00:00:00
abstract：:Seventy-eight patients undergoing mitral valve surgery with or without replacement of the aortic valve also underwent procedures on the tricuspid valve over a period of 10 years. All patients were in functional class III or IV preoperatively. The procedures were performed in all patients with organic disease of the tr...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(89)90324-0
更新日期：1989-04-01 00:00:00
abstract：BACKGROUND:Treatment with trimetazidine (TMZ), 1-[2,3,4-trimethoxybenzyl] piperazine, dihydrochloride, improves cardiac function and ameliorates endothelial dysfunction. However, its potential efficacy against restenosis after balloon injury has not been addressed. We investigated the effect of TMZ on reducing the occu...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2011.12.061
更新日期：2013-07-15 00:00:00
abstract：BACKGROUND/OBJECTIVES:Detecting the presence of coronary artery disease (CAD) is critically important in managing patients with heart failure of uncertain cause. The recently introduced 123I-BMIPP/201TlCl dual myocardial single-photon emission computed tomography (dual SPECT) is potentially a non-invasive diagnostic to...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2014.08.129
更新日期：2014-10-20 00:00:00
abstract：BACKGROUND:Since the differentiation between physiological and pathological trabeculation is challenging, we assessed its distribution in a reference population of selected healthy volunteers. METHODS:We studied 117 subjects (58 males) stratified into age tertiles and by gender. Cardiovascular magnetic resonance image...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2015.03.065
更新日期：2015-04-15 00:00:00
abstract：:We analyzed structural motifs of peptides bound to HLA-DR4 (DRB1*0405 and DRB1*0406) and DR9 (DRB1*0901) and found that: (a) AxxBxC motif where A, B, and C are hydrophobic, hydrophobic, and neutral, respectively, is important for binding to DR4; (b) Gln (Q) or Ser at position C allow high-affinity binding specific to ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/s0167-5273(96)88776-6
更新日期：1996-08-01 00:00:00
abstract：BACKGROUND:The EUROASPIRE I, II and III surveys revealed high prevalences of modifiable risk factors in the high priority group of coronary patients all over Europe. The potential to further reduce coronary heart disease (CHD) morbidity and mortality rates is still considerable. We report here on the relative risk of c...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2012.10.051
更新日期：2013-09-30 00:00:00
abstract：:Inflammatory immune response to self-antigens plays an important role in the development of atherosclerosis. Restoring immune tolerance to self-proteins reduces the pro-inflammatory response. We previously showed that oral tolerance to a combination of two peptides is atheroprotective. In the present study we expresse...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2014.06.001
更新日期：2014-08-01 00:00:00
abstract：:This investigation was carried out to compare the clinical course of patients with chronic Chagas' heart disease with that of patients with dilated cardiomyopathy. A total of 125 patients (75 chagasic and 50 nonchagasic) prospectively followed up at the Cardiomyopathy clinic of Santa Casa Hospital from January 1990 to...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/s0167-5273(97)00083-1
更新日期：1997-07-25 00:00:00
abstract：:The risk of surgical treatment of tetralogy of Fallot was analyzed with multivariate statistical techniques in a recent surgical series (1975-1983) of 159 corrected and 59 palliated patients. The overall mortality of correction was 12.6% and that of palliation was 15.3%. The significant and independent risk factors th...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(85)90398-5
更新日期：1985-09-01 00:00:00
abstract：BACKGROUND/INTRODUCTION:Outcome after ST segment elevation myocardial infarction (STEMI), has improved but patients with high Killip class still have a poor prognosis, and those ≥II need a closer monitoring in a specialized cardiac care unit. PURPOSE:We aimed to determine the predictors of Killip class in a group of p...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2017.07.038
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:The Women's Health Study of Accra was conducted to determine the burden of illness in a representative sampling of adult urban women. METHODS:This community-based survey selected study participants by a 2-stage cluster probability sample stratified by socioeconomic status based on the 2000 Ghanaian census d...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2006.05.004
更新日期：2007-04-12 00:00:00
abstract：:The effects of 5 and 10 mg of amlodipine and of placebo were compared in 21 patients with stable angina pectoris and multivessel coronary artery disease. The blind comparison was performed by means of bicycle ergometry and stress echocardiography using esophageal stimulation of the left heart atrium. All patients subs...
journal_title：International journal of cardiology
pub_type： 临床试验,杂志文章
doi：10.1016/0167-5273(92)90137-r
更新日期：1992-10-01 00:00:00
abstract：:Drug-eluting stent (DES) and bare metal stent (BMS) are effective treatments for preventing vascular disease, but whether using DES is associated with positive clinical outcomes compared with BMS in patients with saphenous vein graft disease (SVGD) has not been established. Three electronic databases including PubMed,...
journal_title：International journal of cardiology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.ijcard.2016.07.001
更新日期：2016-11-01 00:00:00
abstract：:To determine the effect of functional performance, respiratory function, and osteopenia on the quality of life after heart transplantation. Thirty-one patients were included. Functional performance (peak oxygen consumption - pVO2), respiratory function, quality of life (the short form 36 - SF36) and lumbar spine and h...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2006.12.053
更新日期：2008-03-14 00:00:00
abstract：AIM AND METHODS:Gender-related differences in clinical phenotype, in-hospital management and prognosis of acute heart failure (AHF) patients have been previously reported in European and US registries. The ALARM-HF survey is the first to include a cohort of 4953 patients hospitalized for AHF in 666 hospitals in 6 Europ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2012.09.096
更新日期：2013-09-20 00:00:00
abstract：BACKGROUND:Recent studies have demonstrated that undersized ring mitral annuloplasty (URMA) for chronic ischemic mitral regurgitation (CIMR) can induce iatrogenic mitral stenosis. The impact of this functional mitral stenosis on clinical and echocardiographic results is not well established. METHODS:125 consecutive UR...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2011.01.006
更新日期：2012-06-28 00:00:00
abstract：:Pulsus paradoxus or the paradoxical pulse is an exaggeration of the normal inspiratory decrease in systolic blood pressure. The current definition of pulsus paradoxus is an inspiratory drop in systolic blood pressure>10 mm Hg. This physical sign can occur in conditions like cardiac tamponade, constrictive pericarditis...
journal_title：International journal of cardiology
pub_type： 历史文章,杂志文章,收录出版
doi：10.1016/j.ijcard.2009.04.045
更新日期：2010-02-04 00:00:00
abstract：:Several trials have targeted neutral endopeptidase to demonstrate benefits for patients with heart failure. In the PARADIGM-HF trial, a combination of sacubitril and valsartan was superior to enalapril in reducing the risk of death and of hospitalization for heart failure. In this editorial we apply the trial to heart...
journal_title：International journal of cardiology
pub_type： 社论
doi：10.1016/j.ijcard.2016.02.130
更新日期：2016-06-01 00:00:00
abstract：:Giant right atrial aneurysm is a very rare congenital heart defect. We report a case which was diagnosed during fetal life and operated on at 4 months of age with excision of the aneurysmal part and pericardial patch closure. Early repair is recommended to prevent late complications such as arrhythmias and thromboembo...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2007.06.081
更新日期：2008-09-16 00:00:00
abstract：BACKGROUND:After aortic valve replacement (AVR), bicuspid aortic valve (BAV) patients continue to be at risk of aortic complications. Therefore, knowledge of native valve anatomy is important for follow-up. We aimed to determine the extent of which the presence of BAV disease is known in a regional post-AVR population....
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2016.09.084
更新日期：2016-12-15 00:00:00
abstract：BACKGROUND:Existing trials almost exclusively used atenolol to represent the entire β-blocker class, and it is unknown whether there are intra-class differences. We compared the incidence of all-cause and cardiovascular mortality, blood pressure (BP) control and adherence levels between patients newly prescribed atenol...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2014.06.009
更新日期：2014-08-20 00:00:00
abstract：OBJECTIVES:Diabetes mellitus (DM) is an independent risk factor for atrial fibrillation (AF). The role of the NADPH oxidase (NOX) signaling in the setting of DM and the potential benefits of apocynin on diabetic atrial remodeling remain unknown. METHODS:Sixty Japanese rabbits were randomized into 3 groups as follows: ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2016.07.132
更新日期：2016-10-15 00:00:00
abstract：BACKGROUND:This study addresses the impact of availability of on-site catheterization laboratories on the 1-year survival of patients with post-acute myocardial infarction ischemia (P-AMI-I), a high-risk subgroup of AMI patients. METHODS:A prospective 5 month national survey was conducted in 1996 in all operating inte...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/s0167-5273(01)00403-x
更新日期：2001-06-01 00:00:00
abstract：:Revelation of a myocardial bridge has been described at coronary angiography. The pathophysiology of myocardial bridging is incompletely understood. It is sometimes associated with overt pathology, as well as it can just be an incidental finding without any significance. It has been also reported an acute myocardial i...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2007.07.153
更新日期：2009-02-06 00:00:00
abstract：BACKGROUND:Hypertensive patients with IGT have increased risk for cardiovascular disease and progression to diabetes mellitus. Clinical trials suggest that the ARB telmisartan uniquely possesses PPARγ agonistic properties and improves insulin resistance as well as vascular endothelial dysfunction. The aim of the presen...
journal_title：International journal of cardiology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ijcard.2008.10.048
更新日期：2010-03-18 00:00:00
abstract：:Gossypiboma, a term used to describe a mass within the body composed of a cotton matrix which usually refers to a retained surgical sponge, is a rare complication of cardiac surgery. We report one case revealed by the recurrence of the anginal symptoms after successful myocardial revascularisation surgery. The preoper...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/s0167-5273(99)00003-0
更新日期：1999-07-31 00:00:00
abstract：BACKGROUND:The number of people living in high-rise buildings has recently been increasing in Japan, and delayed transport time by emergency-medical-service (EMS) personnel from higher floors could lead to lower survival after out-of-hospital cardiac arrest (OHCA). However, there are no clinical studies assessing the a...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2016.09.047
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:Previous studies demonstrated that scar tissue assessed by late gadolinium enhancement cardiovascular magnetic resonance imaging (LGE-CMR) is associated with recovery of cardiac function after coronary artery bypass graft (CABG) in patients with a history of myocardial infarction (MI). However, information o...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2020.10.052
更新日期：2020-12-06 00:00:00
