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Non-invasive diagnosis of coronary artery disease by 123I-BMIPP/201TlCl dual myocardial SPECT in patients with heart failure.

Abstract：

BACKGROUND/OBJECTIVES:Detecting the presence of coronary artery disease (CAD) is critically important in managing patients with heart failure of uncertain cause. The recently introduced 123I-BMIPP/201TlCl dual myocardial single-photon emission computed tomography (dual SPECT) is potentially a non-invasive diagnostic tool in detecting ischemic heart disease. The aim of our study is to evaluate the efficacy of detecting CAD by dual SPECT in patients with heart failure. METHODS:We studied 501 consecutive patients (366 males, mean age 68±12 years) who were admitted because of heart failure between January 2005 and April 2009. In all patients, the dual SPECT was performed in clinically stabilized states, followed by coronary angiography within 1 week. The polar map of the SPECT image was divided into 17 segments, each scored on a scale of 0-4 based on segmental percent uptake. The mismatch score was defined as the difference between 123I-BMIPP defect score and 201TlCI defect score. The uptake of 201TlCl and 123I-BMIPP was analyzed quantitatively using the Heart Score View software. RESULTS:The 201TlCI defect score and mismatch score were significantly higher in CAD patients than in non-CAD patients. The receiver operating characteristic (ROC) curve revealed that the mismatch score was a significantly more effective marker in detecting the presence of CAD than 201TlCl defect score (area under the curve: 0.84 versus 0.73, p<0.05). Using the mismatch score, the sensitivity and specificity of dual SPECT in detecting CAD were 84% and 83%, respectively. CONCLUSION:Dual SPECT is a useful non-invasive procedure for the detection of CAD in patients with heart failure.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Abe H,Iguchi N,Utanohara Y,Inoue K,Takamisawa I,Seki A,Tanizaki K,Takeda N,Tohbaru T,Asano R,Nagayama M,Takayama M,Umemura J,Sumiyoshi T,Tomoike H

doi

10.1016/j.ijcard.2014.08.129

subject

Has Abstract

pub_date

2014-10-20 00:00:00

pages

969-74

issue

3

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(14)01676-3

journal_volume

176

pub_type

杂志文章

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