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Pharmacological reasons that may explain why randomized clinical trials have failed in acute heart failure syndromes.

Abstract：

:Acute heart failure (AHF) represents a clinical challenge as it encloses a heterogeneous group of syndromes (AHFS) with different pathophysiology, clinical presentations, prognosis and response to therapy. In the last 25years multiple therapeutic targets have been identified and numerous new drugs were evaluated but, up to now, all failed to demonstrate a consistent benefit on clinical outcomes. Moreover, a repeated finding has been the poor correlation between the encouraging results of preclinical and early clinical trials and the lack of effect on outcomes observed in phase III trials. We review several possible pharmacological reasons that may explain the lack of success to develop new drugs and the pharmacological challenges to overcome in the future to develop new more effective and safer drugs for the treatment of AHFS.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Tamargo J,Rosano GM,Delpón E,Ruilope L,López-Sendón J

doi

10.1016/j.ijcard.2016.11.124

subject

Has Abstract

pub_date

2017-04-15 00:00:00

pages

1-11

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(16)33583-5

journal_volume

233

pub_type

杂志文章,评审

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