Abstract：
:Beta-blockers, as determined by four landmark placebo-controlled studies, impart a significant survival advantage to the chronic heart failure population. What ancillary benefits might be expected from beta-blockade, in terms of symptom relief and improvement in exercise capacity, is less clear. This situation in part reflects the heterogeneity of tools used to quantify quality of life and exercise performance as well as factors concerning the statistical handling of symptom and exercise data. In this review we explore the methodology and results of over 20 trials of carvedilol, metoprolol and bisoprolol where quality of life and measures of exercise capacity were end-points. A consistent message relating to a benefit from beta-blockade on these outcomes was elusive but the finding that patients on beta-blockers did at least as well as patients prescribed placebo was a unanimous verdict. There remains a dearth of data to help identify those patients that are at high risk of adverse events from beta-blocker therapy.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Bolger AP,Al-Nasser Fdoi
10.1016/s0167-5273(03)00050-0subject
Has Abstractpub_date
2003-11-01 00:00:00pages
1-8issue
1eissn
0167-5273issn
1874-1754pii
S0167527303000500journal_volume
92pub_type
杂志文章,评审abstract：:Cardiomyopathies (CMPs) are a heterogeneous group of heart muscle diseases with several different phenotypes defined as myocardial disorders in which the heart muscle is structurally and functionally abnormal in the absence of coronary artery disease, hypertension, valvular heart disease and congenital heart disease s...
journal_title：International journal of cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.ijcard.2018.10.091
更新日期：2019-07-01 00:00:00
abstract：:We prospectively studied 69 consecutive patients hospitalized with a primary diagnosis of acute left ventricular failure so as to assess the impact of vasodilators on incidence and morbidity of acute symptomatic left ventricular failure. The determinants of duration of hospitalization, in-hospital mortality and sympto...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(91)90300-e
更新日期：1991-09-01 00:00:00
abstract：:Chronic thromboembolic pulmonary hypertension (CTEPH) is a subgroup of pulmonary hypertension that differs from all other forms of PH in terms of its pathophysiology, patient characteristics and treatment. For implementation of the European Guidelines on Diagnosis and Treatment of Pulmonary Hypertension in Germany, th...
journal_title：International journal of cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.ijcard.2018.08.079
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Early cardiac surgery may have a trade-off between stabilized hemodynamics with controlled infection and a risk of peri-operative death in patients with infective endocarditis (IE) complicated with cardio-embolic strokes. METHODS:We retrospectively studied clinical characteristics and outcomes in 68 consecu...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2016.11.143
更新日期：2017-01-15 00:00:00
abstract：:The human serum HDL-linked paraoxonase enzyme limits the LDL peroxidation by preventing transformation of LDL into biologically active atherogenic particles. Paraoxonase serum activity varies among individuals due to an Gln/Arg polymorphism with low (A phenotype) and high activity (B phenotype). The present study corr...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/s0167-5273(98)00209-5
更新日期：1998-09-30 00:00:00
abstract：:Ventricular tachycardia and ventricular fibrillation are very frequent during transvenous pacing in the presence of acute right ventricular infarction. An acceptable pacing threshold is not usually achieved. A relatively high pacing threshold should, therefore, be accepted in these cases with minimum catheter manipula...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(92)90088-k
更新日期：1992-01-01 00:00:00
abstract：AIM:A fluid challenge with rapid saline infusion during right heart catheterization has been shown to be useful for the differential diagnosis between pre- and post-capillary pulmonary hypertension. The aim of this study was to evaluate the prognostic relevance of fluid challenge-induced changes in pulmonary hemodynami...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2018.03.020
更新日期：2018-06-15 00:00:00
abstract：BACKGROUND:Contrast-enhanced cardiac magnetic resonance imaging (MRI) can depict papillary muscle (PM) necrosis or fibrosis by late enhancement (LE) of PM, but its clinical significance in old myocardial infarction (OMI) has been little understood. METHODS:Myocardial LE and PM-LE were detected with contrast imaging in...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2010.04.037
更新日期：2011-01-07 00:00:00
abstract：BACKGROUND:Angiotensin receptor antagonists (ARBs) improve outcomes in patients with heart failure (HF) with reduced left ventricular ejection fraction, but may induce hyperkalemia (HK) and/or a worsening of renal function (WRF). METHODS AND RESULTS:The incidence and risk factors of HK and its inter-relationship with ...
journal_title：International journal of cardiology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ijcard.2014.02.034
更新日期：2014-05-15 00:00:00
abstract：:Apical ballooning is an increasingly reported transient cardiomyopathy with yet unknown origin. In this study 2 cases of apical ballooning are described in whom we used a combined approach of cardiac magnetic resonance imaging (CMR) and 31-Phosphorous magnetic resonance spectroscopy (31P MRS). Electrocardiogram showed...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2006.06.060
更新日期：2007-05-31 00:00:00
abstract：AIMS:To compare the effect of low (0.3 mg) and commonly prescribed (0.625 mg) doses of conjugated equine estrogens (CEE) on brachial artery flow-mediated dilation and lipid profiles. METHODS AND RESULTS:Twenty-five postmenopausal women (mean age, 65+/-6 years) at risk for coronary artery disease (CAD) (> or =2 establi...
journal_title：International journal of cardiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0167-5273(02)00505-3
更新日期：2003-06-01 00:00:00
abstract：BACKGROUND:Few prospective cohort studies have examined the relationship between reduced left ventricular ejection fraction (LVEF) and other comorbidities for precise risk stratification of sudden cardiac death (SCD) after coronary revascularization. METHODS:We analyzed 9877 consecutive patients who underwent first el...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2009.01.040
更新日期：2010-10-08 00:00:00
abstract：:Blood flow velocities were recorded using Doppler ultrasound in 40 babies aged between 1 day and 4 weeks who had coarctation of the aorta or interruption of the aortic arch. High velocity jets of 3 m/sec or more in the descending aorta were detected in only 3 patients, two of whom had interruption of the aortic arch. ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(89)90333-1
更新日期：1989-04-01 00:00:00
abstract：:Congestive heart failure due to thyrotoxicosis without preexisting heart disease is rare. Indeed, the very existence of a thyrotoxic heart disease has been much discussed. We describe a 44-year-old woman in whom thyrotoxicosis was found to be the sole cause of congestive heart failure. ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(88)90065-4
更新日期：1988-03-01 00:00:00
abstract：BACKGROUND:Right ventricular (RV) failure due to increased pressure load causes significant morbidity and mortality in patients with congenital heart diseases and pulmonary arterial hypertension. It is unknown whether renin-angiotensin-aldosterone-system (RAAS) inhibition (the cornerstone of left ventricular failure tr...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2013.08.102
更新日期：2013-11-05 00:00:00
abstract：:Specific molecules including inflammatory cell adhesion molecules mediate attachment of blood leukocyte and platelets to the endothelium and mononuclear cell migration into the arterial intima. However, the clinical significance of soluble cell adhesion molecules very early in the course of acute coronary syndrome is ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/s0167-5273(02)00564-8
更新日期：2003-08-01 00:00:00
abstract：:Abnormalities of diastolic function are common to virtually all forms of cardiac failure. However, the molecular events leading to diastolic dysfunction have not been fully elucidated. We performed a differential proteomic profiling study on diastolic dysfunction hearts induced by renovascular hypertension. Left ventr...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2007.07.003
更新日期：2008-07-04 00:00:00
abstract：:We assessed the changes in plasma von Willebrand factor level concentration in 10 patients with Q-myocardial infarction and in six patients with non-Q-myocardial infarction who did not receive thrombolytic treatment. Concentrations of von Willebrand factor antigen were measured by an enzyme-linked immunoassay method i...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(96)02735-0
更新日期：1996-10-25 00:00:00
abstract：:Pulse wave analysis (PWA) by radial arterial tonometry is receiving increasing attention for the assessment of central vascular compliance in younger patients. We present five PWA studies performed prospectively on a patient with severe coronary artery disease, and find that the measures of central augmented pressure ...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2009.03.015
更新日期：2011-05-19 00:00:00
abstract：:The purpose of this study was to examine the value of marked left axis deviation in men without apparent heart disease in the assessment of ischemic heart disease risk. In the Manitoba Study, a cohort of 3983 men who were predominantly between 25 to 34 yr of age at entry in 1948, 247 cases of marked left axis deviatio...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(81)90030-9
更新日期：1981-01-01 00:00:00
abstract：BACKGROUND:Risk stratification of patients following acute myocardial infarction (AMI), in order to identify patients whose clinical outcomes can be improved through specific medical interventions, is needed. OBJECTIVES:Development and validation of a prognostic tool comprising a variety of non-cardiovascular co-morbi...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2010.09.014
更新日期：2012-01-26 00:00:00
abstract：:The intrinsic cardiac responses to 2-months Nigella sativa (black seed) oral supplementation (800 mg/kg) in rats were investigated. The isolated hearts were perfused in a Langendorff preparation to demonstrate the effects of N. sativa on the baseline inotropic and chronotropic functions and the myocardial flow rate. N...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2007.07.075
更新日期：2009-01-24 00:00:00
abstract：:Sarcoidosis is a rare granulomatous disease of unknown etiology that can affect any organ. Cardiac involvement, although uncommon, has a wide spectrum of clinical manifestations and is potentially fatal. Although there is no agreement upon a strategy for the diagnosis (which is difficult to make based on clinical info...
journal_title：International journal of cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.ijcard.2003.07.024
更新日期：2004-11-01 00:00:00
abstract：:Doppler echocardiography is extensively used in clinical practice for the screening and detection of pulmonary hypertension (PH). It allows for accurate estimates of pulmonary artery pressures, but with moderate precision, which explains why it is more appropriate for population studies than for definitive diagnosis o...
journal_title：International journal of cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.ijcard.2018.04.024
更新日期：2018-07-15 00:00:00
abstract：:We studied the actions of sandostatin (0.1-1000 nM), an analogue of somatostatin, on human atrial tissues obtained from hearts of 20 patients undergoing corrective cardiac surgery. In 3 preparations showing fast response action potential in normal [K]0 Tyrode solution, sandostatin induced little effect, even at the hi...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(91)90382-y
更新日期：1991-06-01 00:00:00
abstract：BACKGROUND:In the SURVIVE trial, including 1327 acute heart failure patients, no statistically significant difference between levosimendan and dobutamine in the 180-day all-cause mortality was seen. Country-specific differences in outcome were, however, present. In the Finnish sub-population in fact, mortality was sign...
journal_title：International journal of cardiology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ijcard.2016.04.064
更新日期：2016-07-15 00:00:00
abstract：:A 54-year-old woman without organic heart disease presented with presyncopal symptoms during work. A decreased cardiac output was demonstrated by haemodynamic measurements during exercise. Treatment with fludrocortisone and ephedrine was initiated with a good haemodynamic and symptomatic result. ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(90)90255-4
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND:Studies in patients support a beneficial effect of statin treatment early after acute coronary syndrome and/or prior percutaneous coronary intervention. However, statin effect during total occlusion remains unknown. OBJECTIVES:To investigate whether infusion of activated simvastatin during ischemia and prio...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2014.06.040
更新日期：2014-08-20 00:00:00
abstract：BACKGROUND:Patients with acute coronary syndrome (ACS) associated to high C-reactive protein (CRP) levels exhibit a higher risk of future acute ischemic events. Yet, the positive predictive value of CRP is too low to guide a specific treatment. Our study aims to identify a high-risk patient subset who might mostly bene...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2019.01.058
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:beta-blocker therapy for dilated or ischemic cardiomyopathy is now an accepted and effective treatment. However, little is known about its efficacy in patients with postoperative impaired left ventricular function. This retrospective study was designed to assess the effects of beta-blocker therapy in patient...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/s0167-5273(99)00215-6
更新日期：2000-03-31 00:00:00
