当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF CARDIOLOGY期刊下所有文献 > A cornerstone of heart failure treatment is not effective in experimental right ventricular failure.

A cornerstone of heart failure treatment is not effective in experimental right ventricular failure.

Abstract：

BACKGROUND:Right ventricular (RV) failure due to increased pressure load causes significant morbidity and mortality in patients with congenital heart diseases and pulmonary arterial hypertension. It is unknown whether renin-angiotensin-aldosterone-system (RAAS) inhibition (the cornerstone of left ventricular failure treatment) is effective in RV failure. We investigated the effects of combination treatment of aldosterone-blocker eplerenone+angiotensin II receptor blocker losartan (Ep/Lo) on RV remodeling and function in a model of RV failure due to increased pressure load. METHODS AND RESULTS:Rats (n=48) were randomized for pulmonary artery banding (PAB) or sham surgery and for losartan (20 mg/kg/d)+eplerenone (100 mg/kg/d) treatment (Ep/Lo) or vehicle (VEH). RV function was assessed by echocardiography and pressure-volume analysis at 5 and 11 weeks, or at the occurrence of clinical RV failure symptoms necessitating termination. PAB resulted in RV failure in all rats, as defined by reduced cardiac output, RV stroke volume, increased RV end diastolic pressure and liver congestion as well as RV fibrosis, hypertrophy and reduced capillary density. Clinical RV failure necessitated termination in 5/12 PAB-VEH rats. Angiotensin II type 1-receptor expression in the RV was reduced in PAB rats indicating local RAAS activation. Treatment of PAB rats with Ep/Lo significantly lowered arterial pressures, but had no significant effect on RV function, remodeling or survival compared to PAB-VEH rats. CONCLUSIONS:RAAS inhibition does not beneficially affect experimental RV failure due to chronic pressure load. This is of high clinical relevance, because it indicates that the RV response to RAAS inhibition might fundamentally differ from that of the LV.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Borgdorff MA,Bartelds B,Dickinson MG,Steendijk P,Berger RM

doi

10.1016/j.ijcard.2013.08.102

subject

Has Abstract

pub_date

2013-11-05 00:00:00

pages

183-9

issue

3

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(13)01685-9

journal_volume

169

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF CARDIOLOGY文献大全
  • Aspirin decreases vascular endothelial growth factor release during myocardial ischemia.

    abstract：BACKGROUND:Vascular Endothelial Growth Factor (VEGF) is an important angiogenesis factor involved in pathophysiology of cardiovascular diseases. Controlling this factor's level in the serum might have significant prognostic outcomes. METHODS:Twenty-four patients undergoing coronary artery bypass grafting were prospect...

    journal_title：International journal of cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.ijcard.2003.03.007

    authors： Gerrah R,Fogel M,Gilon D

    更新日期：2004-03-01 00:00:00

  • Cerebral haemorrhage in anticoagulated patients with non-septic mechanical valvular prosthesis.

    abstract：:Cerebral haemorrhage in anticoagulated patients with mechanical valvular prosthesis poses an uncommon but difficult management problem. Four such patients are presented: one patient had delayed haemorrhagic transformation of a preexisting cerebral infarct, one probably had de novo haemorrhage complicating hypertension...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(91)90005-a

    authors： Lau CP,Chang CM,Lau GK,Wong CK,Fong PC,Yu YL

    更新日期：1991-03-01 00:00:00

  • Protective effects of valsartan against cigarette smoke-induced left ventricular systolic dysfunction in rats.

    abstract：OBJECTIVES:To investigate the protective effects of valsartan against smoking-induced left ventricular dysfunction and explore the potential mechanisms involved. METHODS:Rats were randomly divided into 3 groups: smoking group (exposed to cigarette smoke), valsartan group (exposed to cigarette smoke and treated orally ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2012.03.068

    authors： Zhou X,Li C,Xu W,Chen J

    更新日期：2013-08-10 00:00:00

  • Neonates and infants requiring life-long cardiac pacing: How reliable are epicardial leads through childhood?

    abstract：BACKGROUND:In the literature, data is lacking on mid-term results of epicardial pacemaker implantation in neonates and infants. Our aim was to evaluate the mid-term results of epicardial pacemakers implanted in infants under 1 year of age. METHODS AND RESULTS:We conducted a retrospective review of patients who underwe...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2019.10.008

    authors： Stanner C,Horndasch M,Vitanova K,Strbad M,Ono M,Hessling G,Lange R,Cleuziou J

    更新日期：2019-12-15 00:00:00

  • 30 days and midterm outcomes of patients undergoing percutaneous replacement of aortic valve according to their renal function: a multicenter study.

    abstract：INTRODUCTION:Chronic kidney disease (CKD) constitutes a predictor of adverse events for surgical aortic valve replacement. In patients undergoing TAVI no study was performed to evaluate outcomes according to renal clearance, which represents the most accurate instrument to assess kidney function. METHODS:From January ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ijcard.2012.04.161

    authors： D'Ascenzo F,Moretti C,Salizzoni S,Bollati M,D'Amico M,Ballocca F,Giordana F,Barbanti M,Ussia GP,Brambilla N,Bedogni F,Biondi Zoccai G,Tamburino C,Gaita F,Sheiban I

    更新日期：2013-08-20 00:00:00

  • Relationship of peripheral and coronary artery disease to cardiovascular events in patients with atrial fibrillation.

    abstract：BACKGROUND:To investigate the impact of concomitant asymptomatic peripheral artery disease (PAD) and pre-existing coronary artery disease (CAD) on cardiovascular events (CVEs) in atrial fibrillation (AF) patients. METHODS:Prospective multicenter study including 1138 anticoagulated AF patients. PAD was diagnosed by can...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ijcard.2017.12.076

    authors： Pastori D,Pignatelli P,Sciacqua A,Perticone M,Violi F,Lip GYH

    更新日期：2018-03-15 00:00:00

  • Von Willebrand factor in patients evolving Q-wave versus non-Q-wave acute myocardial infarction.

    abstract：:We assessed the changes in plasma von Willebrand factor level concentration in 10 patients with Q-myocardial infarction and in six patients with non-Q-myocardial infarction who did not receive thrombolytic treatment. Concentrations of von Willebrand factor antigen were measured by an enzyme-linked immunoassay method i...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(96)02735-0

    authors： Tousoulis D,Tentolouris C,Bosinakou E,Apostolopoulos T,Kyriakides M,Toutouzas P

    更新日期：1996-10-25 00:00:00

  • Increased basal tone and hyperresponsiveness to acetylcholine and ergonovine in spasm-related coronary arteries in patients with variant angina.

    abstract：:We compared the basal coronary artery tone and the constrictive responses to acetylcholine (Ach) and ergonovine (Erg) among three groups of patients: 31 patients (group 1) with variant angina in whom spasm was provoked by low doses of acetylcholine (intracoronary 20 micrograms) or ergonovine (intravenous 50 micrograms...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：

    authors： Lee SJ,Park SJ,Park SW,Kim JJ,Song JK,Hong MK,Kang DH,Cheong SS

    更新日期：1996-07-26 00:00:00

  • Localization of CD8 T cell epitope within cardiac myosin heavy chain-α334-352 that induces autoimmune myocarditis in A/J mice.

    abstract：BACKGROUND:Cardiac myosin heavy chain-α (Myhc), an intracellular protein expressed in the cardiomyocytes, has been identified as a major autoantigen in cardiac autoimmunity. In our studies with Myhc334-352-induced experimental autoimmune myocarditis in A/J mice (H-2a), we discovered that Myhc334-352, supposedly a CD4 T...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2015.09.016

    authors： Massilamany C,Gangaplara A,Basavalingappa RH,Rajasekaran RA,Khalilzad-Sharghi V,Han Z,Othman S,Steffen D,Reddy J

    更新日期：2016-01-01 00:00:00

  • Cardiac arrhythmias in pregnancy: clinical and therapeutic considerations.

    abstract：:Pregnancy can precipitate cardiac arrhythmias not previously present in seemingly well individuals. Risk of arrhythmias is relatively higher during labor and delivery. Potential factors that can promote arrhythmias in pregnancy and during labor and delivery include the direct cardiac electrophysiological effects of ho...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/s0167-5273(02)00601-0

    authors： Gowda RM,Khan IA,Mehta NJ,Vasavada BC,Sacchi TJ

    更新日期：2003-04-01 00:00:00

  • Predictors and prognostic consequence of gastrointestinal bleeding in patients with ST-segment elevation myocardial infarction.

    abstract：BACKGROUND:Limited data are available on the predictors and implications of gastrointestinal (GI) bleeding in ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PPCI) and dual antiplatelet therapy. METHODS AND RESULTS:Predictors of and clinical outcome ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2015.01.041

    authors： Kikkert WJ,Hassell MECJ,Delewi R,van der Laan MH,Baan J Jr,Vis MM,Koch KT,de Winter RJ,Piek JJ,Tijssen JGP,Henriques JPS

    更新日期：2015-04-01 00:00:00

  • Heart failure in patients with human immunodeficiency virus infection: Epidemiology and management disparities.

    abstract：BACKGROUND:Persons living with HIV are at a higher risk of cardiovascular disease despite effective antiretroviral therapy and dramatic reductions in AIDS-related conditions. We sought to identify the epidemiology of heart failure (HF) among persons living with HIV in the United States in an era of contemporary antiret...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2016.05.027

    authors： Al-Kindi SG,ElAmm C,Ginwalla M,Mehanna E,Zacharias M,Benatti R,Oliveira GH,Longenecker CT

    更新日期：2016-09-01 00:00:00

  • Is activation in inflammatory bowel diseases associated with further impairment of coronary microcirculation?

    abstract：BACKGROUND:Inflammatory bowel disease [IBD] includes a number of chronic relapsing diseases. In IBD intestinal microvascular endothelial cells are damaged by an abnormal immune response. Several studies have shown that IBD may cause increment in risk of developing atherosclerosis. IBD in activation was related to enhan...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2016.08.141

    authors： Caliskan Z,Keles N,Gokturk HS,Ozdil K,Aksu F,Ozturk O,Kahraman R,Kostek O,Tekin AS,Ozgur GT,Caliskan M

    更新日期：2016-11-15 00:00:00

  • Parasympathetic overactivity and its evaluation in patients with sinus nodal dysfunction.

    abstract：:In 17 controls, and 17 patients with sinus nodal dysfunction, an electrophysiologic study was made of sinus nodal function and atrioventricular nodal conduction in the basal state. The study was then repeated in all patients after atropine. The heart rate, mean sinus cycle length, variations of sinus cycle length, sin...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(91)90064-v

    authors： Hluchý J,Milovský V,Pavlovic M,Uhliariková H,Makovíni M

    更新日期：1991-12-01 00:00:00

  • Management of cardiac myxoma during pregnancy: a case series and review of the literature.

    abstract：:Cardiac myxomas are the most common primary benign tumors of the heart. The reported incidence during pregnancy is extremely low with only 17 reported cases in the medical literature. Standard therapy involves surgical resection given the potential for embolization. In the pregnant patient, however, the risks of embol...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijcard.2011.05.069

    authors： John AS,Connolly HM,Schaff HV,Klarich K

    更新日期：2012-03-08 00:00:00

  • The effect of configuration parameters of time-frequency maps in the detection of intra-QRS electrical transients of the signal-averaged electrocardiogram: impact in clinical diagnostic performance.

    abstract：:Time-frequency maps of signal-averaged electrocardiogram based on a short time Fourier transform (STFT) technique analysis was employed to assess the presence of high frequency electrical transients (turbulence) and arrhythmia risk assessment. The optimal configuration set of STFT variables aiming at risk stratificati...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2009.04.013

    authors： Benchimol-Barbosa PR,Nasario-Junior O,Nadal J

    更新日期：2010-11-05 00:00:00

  • Transvenous pacing in the presence of acute right ventricular infarction.

    abstract：:Ventricular tachycardia and ventricular fibrillation are very frequent during transvenous pacing in the presence of acute right ventricular infarction. An acceptable pacing threshold is not usually achieved. A relatively high pacing threshold should, therefore, be accepted in these cases with minimum catheter manipula...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(92)90088-k

    authors： Mittal SR,Mahar MS,Gokhroo RK

    更新日期：1992-01-01 00:00:00

  • Accuracy of percussion of the left cardiac border.

    abstract：UNLABELLED:The purpose of this study was to determine the accuracy of percussion of the left cardiac border. Sixty-six adult patients were studied. The left cardiac border as determined by percussion and marked with a calibrated lead marker was compared with that obtained by a chest X-ray. The error in locating the lef...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(92)90267-7

    authors： Karnegis JN,Kadri N

    更新日期：1992-12-01 00:00:00

  • The relationship of marked left axis deviation to the risk of ischemic heart disease.

    abstract：:The purpose of this study was to examine the value of marked left axis deviation in men without apparent heart disease in the assessment of ischemic heart disease risk. In the Manitoba Study, a cohort of 3983 men who were predominantly between 25 to 34 yr of age at entry in 1948, 247 cases of marked left axis deviatio...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(81)90030-9

    authors： Rabkin SW,Mathewson FA,Tate RB

    更新日期：1981-01-01 00:00:00

  • Recanalization strategy of retrograde angioplasty in patients with coronary chronic total occlusion -analysis of 24 cases, focusing on technical aspects and complications.

    abstract：BACKGROUND:Retrograde approach through collateral channels was recently proposed to increase the success rate of percutaneous coronary intervention (PCI) for coronary chronic total occlusion (CTO), but this approach is still an incompletely described technique. METHODS:We analyzed 24 cases of retrograde PCI for CTO, w...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2009.04.020

    authors： Lee NH,Seo HS,Choi JH,Suh J,Cho YH

    更新日期：2010-10-08 00:00:00

  • A systematic review and meta-analysis of multidetector computed tomography in the assessment of coronary artery bypass grafts.

    abstract：PURPOSE:The present meta-analysis aimed to compare the diagnostic accuracy of more recent computed tomography coronary angiography (CTCA) with invasive coronary angiography (ICA) in the assessment of graft patency after coronary artery bypass graft surgery (CABG). MATERIAL AND METHODS:A systematic review was performed...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.ijcard.2016.06.264

    authors： Chan M,Ridley L,Dunn DJ,Tian DH,Liou K,Ozdirik J,Cheruvu C,Cao C

    更新日期：2016-10-15 00:00:00

  • Cost analysis of radiofrequency catheter ablation for atrial fibrillation.

    abstract：:Atrial fibrillation is the most common arrhythmia associated with increased mortality and morbidity. Its management requires high healthcare expenditures; 52%-70% of expenses for AF care are constituted by hospitalization costs. The current management strategies of pharmacological rhythm control and pharmacological or...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijcard.2013.01.028

    authors： Gorenek B,Kudaiberdieva G

    更新日期：2013-09-10 00:00:00

  • Intracoronary abciximab reduces death and major adverse cardiovascular events in acute coronary syndromes: a meta-analysis of clinical trials.

    abstract：BACKGROUND:Successful reperfusion of epicardial coronary arteries does not necessarily result in actual myocardial perfusion. Local intracoronary (IC) delivery of GP IIb/IIIa inhibitors (GPI) has been proposed to achieve further clinical efficacy when compared to standard intravenous (IV) administration. However clinic...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.ijcard.2012.12.003

    authors： De Rosa S,Caiazzo G,Torella D,Indolfi C

    更新日期：2013-09-30 00:00:00

  • Sex and age differences and outcomes in acute coronary syndromes.

    abstract：BACKGROUND:There is conflicting information about sex differences in presentation, treatment, and outcome after acute coronary syndromes (ACS) in the era of reperfusion therapy and percutaneous coronary intervention. The aim of this study was to examine presentation, acute therapy, and outcomes of men and women with AC...

    journal_title：International journal of cardiology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.ijcard.2016.06.217

    authors： Vasiljevic-Pokrajcic Z,Mickovski N,Davidovic G,Asanin M,Stefanovic B,Krljanac G,Radosavljevic-Radovanovic M,Radovanovic N,Lasica R,Milanović S,Bjekić J,Majstorovic-Stakic M,Trifunovic D,Karadzic A,Rajic D,Milosevic A,Zdra

    更新日期：2016-08-01 00:00:00

  • Lvad pump speed increase is associated with increased peak exercise cardiac output and vo2, postponed anaerobic threshold and improved ventilatory efficiency.

    abstract：BACKGROUNDS:Peak exercise cardiac output (CO) increase is associated with an increase of peak oxygen uptake (VO2), provided that arteriovenous O2 difference [Δ(Ca-Cv)O2] does not decrease. At anaerobic threshold, VO2, is related to CO. We tested the hypothesis that, in heart failure (HF) patients with left ventricular ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ijcard.2016.12.112

    authors： Vignati C,Apostolo A,Cattadori G,Farina S,Del Torto A,Scuri S,Gerosa G,Bottio T,Tarzia V,Bejko J,Sisillo E,Nicoli F,Sciomer S,Alamanni F,Paolillo S,Agostoni P

    更新日期：2017-03-01 00:00:00

  • No effects of human ghrelin on cardiac function despite profound effects on body composition in a rat model of heart failure.

    abstract：BACKGROUND:Ghrelin, was observed to have treatment-potential for severe chronic heart failure (CHF) and cardiac cachexia based on anti-cachectic and cardio-protective effects. METHODS:We performed two studies to assess the effects of human ghrelin on food intake, body weight and body composition, as well as heart func...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2008.06.094

    authors： Akashi YJ,Palus S,Datta R,Halem H,Taylor JE,Thoene-Reineke C,Dong J,Thum T,Culler MD,Anker SD,Springer J

    更新日期：2009-11-12 00:00:00

  • Influence of circumferential pulmonary vein isolation for atrial fibrillation on ST elevation in patient with Brugada syndrome.

    abstract：:We present a patient with Brugada syndrome and paroxysmal atrial fibrillation who underwent circumferential pulmonary vein isolation. His electrocardiogram showed normal sinus rhythm and first-degree AV block (P-R 280 ms) with coved-type ST elevation in V1-2 (+2.0 mm) before ablation. During ablation around the left p...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2009.04.010

    authors： Tomita T,Aizawa K,Shimada K,Motoki H,Otagiri K,Koshikawa M,Kasai H,Izawa A,Kumazaki S,Tsutsui H,Koyama J,Ikeda U

    更新日期：2011-06-02 00:00:00

  • Magnitude of QRS duration reduction after biventricular pacing identifies responders to cardiac resynchronization therapy.

    abstract：BACKGROUND:Several studies have investigated the association between native QRS duration (QRSd) or QRS narrowing and response to biventricular pacing. However, their results have been conflicting. The aim of our study was to determine the association between the relative change in QRS narrowing index (QI) and clinical ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ijcard.2016.06.203

    authors： Coppola G,Ciaramitaro G,Stabile G,DOnofrio A,Palmisano P,Carità P,Mascioli G,Pecora D,De Simone A,Marini M,Rapacciuolo A,Savarese G,Maglia G,Pepi P,Padeletti L,Pierantozzi A,Arena G,Giovannini T,Caico SI,Nugara C,

    更新日期：2016-10-15 00:00:00

  • Transcatheter aortic valve replacement versus surgical aortic valve replacement in patients with previous coronary artery bypass surgery: A systematic review and meta-analysis.

    abstract：BACKGROUND:Patients with severe aortic stenosis (AS) and previous coronary artery bypass graft (CABG) surgery have increased risk for aortic valve replacement. Whether surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR) offers better outcomes in this population is unclear. We aimed...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.ijcard.2016.04.033

    authors： Ando T,Briasoulis A,Holmes AA,Afonso L,Schreiber T,Kondur A

    更新日期：2016-07-15 00:00:00

  • Current pathophysiological concepts and management of pulmonary hypertension.

    abstract：:Pulmonary hypertension (PH), increasingly recognized as a major health burden, remains underdiagnosed due mainly to the unspecific symptoms. Pulmonary arterial hypertension (PAH) has been extensively investigated. Pathophysiological knowledge derives mostly from experimental models. Paradoxically, common non-PAH PH fo...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijcard.2011.05.066

    authors： Lourenço AP,Fontoura D,Henriques-Coelho T,Leite-Moreira AF

    更新日期：2012-03-22 00:00:00