Abstract:
OBJECTIVE:The wide spectrum of intracardiac anatomy and reparative surgery available for adults with congenital heart disease (ACHD) makes uniform measurement of cardiac size and disease severity challenging. The aim of this study was to assess the prognostic potential of cardiothoracic ratio, a simple marker of cardiomegaly, in a large cohort of ACHD. PATIENTS AND SETTING:Chest radiographs from 3033 ACHD patients attending our institution between 1998 and 2007 and 113 normal controls of similar age were analyzed blindly. DESIGN:Cardiothoracic ratio derived from plain postero-anterior chest radiographs, was compared between ACHD patients and controls, different diagnostic subgroups and different functional classes. Relationship between cardiothoracic ratio and survival was assessed using Cox regression. RESULTS:Average cardiothoracic ratio in ACHD was 52.0±7.6% (over 50% in 56.4%), significantly higher in all ACHD diagnostic subgroups compared to controls (42.3±4.0%, p<0.0001) and highest in the "complex" cardiac anatomy, Ebstein's anomaly and Eisenmenger subgroups. Cardiothoracic ratio related to functional class, but was high even in asymptomatic patients. During a median follow-up of 4.2years, 164 patients died. Patients with a cardiothoracic ratio >55% had an 8-fold increased risk of death compared to those in the lowest tertile (<48%). Even patients with mildly increased cardiothoracic ratio (48-55%) had an adjusted 3.6-fold increased mortality compared to the lowest tertile. CONCLUSIONS:Cardiothoracic ratio derived from postero-anterior chest radiographs is a simple, and reproducible marker, which relates to functional class and predicts independently mortality risk in ACHD patients.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Dimopoulos K,Giannakoulas G,Bendayan I,Liodakis E,Petraco R,Diller GP,Piepoli MF,Swan L,Mullen M,Best N,Poole-Wilson PA,Francis DP,Rubens MB,Gatzoulis MAdoi
10.1016/j.ijcard.2011.10.125subject
Has Abstractpub_date
2013-06-20 00:00:00pages
453-7issue
2eissn
0167-5273issn
1874-1754pii
S0167-5273(11)02016-Xjournal_volume
166pub_type
杂志文章abstract:BACKGROUND/OBJECTIVE:Despite the effectiveness of first generation drug eluting stent, DES-1 (Taxus and Cypher) in avoiding restenosis and the need for new revascularizations, a slightly increase in stent thrombosis, ST have been published. Second generation drug eluting stent, DES-2 has been developed to optimize the ...
journal_title:International journal of cardiology
pub_type: 杂志文章,meta分析
doi:10.1016/j.ijcard.2011.04.004
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abstract::The prognostic value of thallium-201 imaging in patients with unstable angina is not well established. Forty consecutive patients with unstable angina who had responded to medical therapy underwent predischarge symptom-limited exercise testing and 39 of them underwent exercise thallium-201 imaging, on average 3 days a...
journal_title:International journal of cardiology
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journal_title:International journal of cardiology
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abstract:BACKGROUND:We aimed to study differences in the prescribing of warfarin, aspirin and statins to patients with atrial fibrillation (AF) in socio-economically diverse neighborhoods. We also aimed to explore the effects of neighborhood deprivation on the relationship between CHADS2 risk score and warfarin prescription. M...
journal_title:International journal of cardiology
pub_type: 杂志文章
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abstract:BACKGROUND:It is unclear whether ischemic stroke patients with known atrial fibrillation (KAF) had different outcomes than those with atrial fibrillation diagnosed after stroke (AFDAS). We aimed to explore the characteristics and outcomes in ischemic stroke patients with KAF or AFDAS. METHODS:Consecutive patients hosp...
journal_title:International journal of cardiology
pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 信件
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journal_title:International journal of cardiology
pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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更新日期:1986-06-01 00:00:00
abstract:BACKGROUND:Despite frequent life-long hemodynamic and electrophysiologic abnormalities, adults with congenital heart defects (CHDs) are often lost to medical follow-up. Using a cohort of adults with CHD receiving hospital care in Arkansas, we sought to determine how often a CHD is recognized and coded during hospital a...
journal_title:International journal of cardiology
pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.ijcard.2017.04.037
更新日期:2017-08-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2008.05.005
更新日期:2009-08-21 00:00:00
abstract:BACKGROUND:Myotonic dystrophy is associated with arrhythmias and risk of sudden death but also with symptoms of heart failure. Our study aimed to identify early biventricular dysfunction in asymptomatic patients with myotonic dystrophy by tissue Doppler. METHODS:Thirty-six patients with myotonic dystrophy (M/F=20/16, ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2006.06.056
更新日期:2007-05-31 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(91)90129-d
更新日期:1991-01-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2020.08.101
更新日期:2021-01-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2017.01.057
更新日期:2017-03-15 00:00:00
abstract:BACKGROUND:Myocardial CCN2/CTGF (connective tissue growth factor) is strongly induced in heart failure (HF) and acts as a cardioprotective factor in ischemia/reperfusion injury. However, its functional role in myocardial hypertrophy remains unresolved. METHODS AND RESULTS:Transgenic mice with cardiac-restricted overex...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2013.01.165
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2004.12.077
更新日期:2005-11-02 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2012.02.014
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journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2009.09.468
更新日期:2010-05-14 00:00:00
abstract::Increased lipid oxidative stress has been recently implicated in the pathogenesis of coronary artery spasm. Small, dense LDL with high susceptibility to oxidation may be linked to the genesis of coronary vasospasm. The relative migratory distance of the predominant densitometric peak of LDL from that of VLDL to that o...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
doi:10.1016/s0167-5273(02)00250-4
更新日期:2003-02-01 00:00:00
abstract:BACKGROUND:Atrial electrophysiological abnormalities have previously been reported in Brugada syndrome. We investigated the incidence and electrocardiographic predictors of atrial fibrillation (AF) in a Chinese cohort of Brugada syndrome patients. METHODS:A retrospective study of Brugada syndrome patients admitted to ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2020.05.007
更新日期:2020-09-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2015.04.144
更新日期:2015-01-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2008.11.129
更新日期:2010-06-11 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2018-01-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2017-08-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2016-10-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(95)02468-9
更新日期:1995-12-01 00:00:00
abstract::A 72-year-old man with a large mass in the right atrium and the pulmonary embolism by chest computed tomography was diagnosed as the primary cardiac B-cell lymphoma (PCL) with pulmonary tumor embolism and pericardial effusion. Upon completion of initial chemotherapy, the mass was markedly reduced, and the pulmonary em...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2005.06.054
更新日期:2006-07-28 00:00:00