Mesoderm/mesenchyme homeobox gene l promotes vascular smooth muscle cell phenotypic modulation and vascular remodeling.

Abstract:

AIMS:To investigate the role of mesoderm/mesenchyme homeobox gene l (Meox1) in vascular smooth muscle cells (SMCs) phenotypic modulation during vascular remodeling. METHODS AND RESULTS:By using immunostaining, Western blot, and histological analyses, we found that Meox1 was up-regulated in PDGF-BB-treated SMCs in vitro and balloon injury-induced arterial SMCs in vivo. Meox1 knockdown by shRNA restored the expression of contractile SMCs phenotype markers including smooth muscle α-actin (α-SMA) and calponin. In contrast, overexpression of Moex1 inhibited α-SMA and calponin expressions while inducing the expressions of synthetic SMCs phenotype markers such as matrix gla protein, osteopontin, and proliferating cell nuclear antigen. Mechanistically, Meox1 mediated the SMCs phenotypic modulation through FAK-ERK1/2 signaling, which appears to induce autophagy in SMCs. In vivo, knockdown of Meox1 attenuated injury-induced neointima formation and promoted SMCs contractile proteins expressions. Meox1 knockdown also reduced the number of proliferating SMCs, suggesting that Meox1 was important for SMCs proliferation in vivo. Moreover, knockdown of Meox1 attenuated ERK1/2 signaling and autophagy markers expressions, suggesting that Meox1 may promote SMCs phenotypic modulation via ERK1/2 signaling-autophagy in vivo. CONCLUSION:Our data indicated that Meox1 promotes SMCs phenotypic modulation and injury-induced vascular remodeling by regulating the FAK-ERK1/2-autophagy signaling cascade. Thus, targeting Meox1 may be an attractive approach for treating proliferating vascular diseases.

journal_name

Int J Cardiol

authors

Wu B,Zhang L,Zhu YH,Zhang YE,Zheng F,Yang JY,Guo LY,Li XY,Wang L,Tang JM,Chen SY,Wang JN

doi

10.1016/j.ijcard.2017.10.098

subject

Has Abstract

pub_date

2018-01-15 00:00:00

pages

82-89

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(17)35323-8

journal_volume

251

pub_type

杂志文章
  • Peri-procedural thrombocytopenia after aortic bioprosthesis implant: A systematic review and meta-analysis comparison among conventional, stentless, rapid-deployment, and transcatheter valves.

    abstract:BACKGROUND:Thrombocytopenia has been shown to occur soon after surgical biological aortic valve replacement (AVR), and recently reported also after transcatheter valve implantation (TAVI). The mechanism underlying this phenomenon is still unknown, and its clinical impact on the peri-operative outcome has been poorly in...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.ijcard.2019.07.056

    authors: Jiritano F,Santarpino G,Serraino GF,Ten Cate H,Matteucci M,Fina D,Mastroroberto P,Lorusso R

    更新日期:2019-12-01 00:00:00

  • A new method of applying randomised control study data to the individual patient: A novel quantitative patient-centred approach to interpreting composite end points.

    abstract:BACKGROUND:Modern randomised controlled trials typically use composite endpoints. This is only valid if each endpoint is equally important to patients but few trials document patient preference and seek the relative importance of components of combined endpoints. If patients weigh endpoints differentially, our interpre...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.ijcard.2015.05.109

    authors: Ahmad Y,Nijjer S,Cook CM,El-Harasis M,Graby J,Petraco R,Kotecha T,Baker CS,Malik IS,Bellamy MF,Sethi A,Mikhail GW,Al-Bustami M,Khan M,Kaprielian R,Foale RA,Mayet J,Davies JE,Francis DP,Sen S

    更新日期:2015-09-15 00:00:00

  • Sulpiride induced torsade de pointes.

    abstract::Antipsychotic agents are known to be associated with a long QT interval and torsade de pointes. We report a 69 year old female who suffered from a syncopal attack at a psychiatric hospital and was referred to our center. Torsade de pointes with a long QT interval (QTc=680 ms) was observed on the 12 lead ECG in the eme...

    journal_title:International journal of cardiology

    pub_type: 信件

    doi:10.1016/j.ijcard.2007.01.060

    authors: Huang BH,Hsia CP,Chen CY

    更新日期:2007-06-12 00:00:00

  • Diabetes mellitus and risk of ischemic stroke in patients with heart failure and no atrial fibrillation.

    abstract:OBJECTIVE:The risk of ischemic stroke, systemic thromboembolism, and all-cause death among heart failure patients previously diagnosed with diabetes mellitus is poorly described. We evaluated the risk of these endpoints among heart failure patients without diagnosed atrial fibrillation according to the presence of diab...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2016.02.004

    authors: Melgaard L,Gorst-Rasmussen A,Søgaard P,Rasmussen LH,Lip GY,Larsen TB

    更新日期:2016-04-15 00:00:00

  • A contemporary risk model for predicting 30-day mortality following percutaneous coronary intervention in England and Wales.

    abstract:BACKGROUND:The current risk model for percutaneous coronary intervention (PCI) in the UK is based on outcomes of patients treated in a different era of interventional cardiology. This study aimed to create a new model, based on a contemporary cohort of PCI treated patients, which would: predict 30 day mortality; provid...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2016.02.085

    authors: McAllister KS,Ludman PF,Hulme W,de Belder MA,Stables R,Chowdhary S,Mamas MA,Sperrin M,Buchan IE,British Cardiovascular Intervention Society and the National Institute for Cardiovascular Outcomes Research.

    更新日期:2016-05-01 00:00:00

  • Release of matrix metalloproteinase-9 during balloon angioplasty in patients with stable angina. A preliminary study.

    abstract:BACKGROUND:Vascular wall remodeling is a major factor contributing to restenosis after angioplasty that involves migration and proliferation of vascular smooth muscle cells. The release of matrix-degrading metalloproteinases, including metalloproteinase-2 and metalloproteinase-9, facilitates remodeling. Experimental da...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/s0167-5273(03)00092-5

    authors: Cedro K,Radomski A,Radomski MW,Ruźyłło W,Herbaczyńska-Cedro K

    更新日期:2003-12-01 00:00:00

  • Six-month follow-up evaluation for everolimus-eluting stents by intracoronary optical coherence tomography: comparison with paclitaxel-eluting stents.

    abstract:BACKGROUND:Although several clinical trials have shown the superior efficacy and safety of second-generation everolimus-eluting stents (EES) in comparison with first-generation paclitaxel-eluting stents (PES), the differences in the vascular healing process between EES and PES in a human coronary artery during an early...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2011.10.102

    authors: Takano M,Murakami D,Yamamoto M,Kurihara O,Murai K,Inami T,Kimata N,Ohba T,Seino Y,Mizuno K

    更新日期:2013-06-05 00:00:00

  • Target organ damage in hypertensive patients of different ethnic groups.

    abstract:BACKGROUND:Hypertension is associated with involvement of target organs which varies among the different ethnic groups. The multiplicity of the population in Israel offers an opportunity for evaluating target organ damage in hypertensive patients of different ethnic origins. METHODS AND RESULTS:Data were collected fro...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2006.03.049

    authors: Wolak T,Anfanger S,Wolak A,Furman T,Abuara'ar T,Biton A,Pilpel D,Paran E

    更新日期:2007-03-20 00:00:00

  • Infective endocarditis following patch closure of ventricular septal defect: a cross-sectional Doppler echocardiographic study.

    abstract::Cross-sectional and Doppler echocardiographic characteristics of infective endocarditis are described in six cases following patch closure of a ventricular septal defect. The patients presented to us with fever one to five months after surgery. Five of them also had congestive cardiac failure. Cross-sectional echocard...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/0167-5273(89)90158-7

    authors: Shrivastava S,Radhakrishnan S

    更新日期:1989-10-01 00:00:00

  • Relationship of CRP, IL-6, and fibrinogen with right ventricular structure and function: the MESA-Right Ventricle Study.

    abstract:BACKGROUND/OBJECTIVES:Inflammation contributes to the pathogenesis of disease associated with the left ventricle (LV); yet, our understanding of the effect of inflammation on the right ventricle (RV) is quite limited. METHODS AND RESULTS:The relationships of C-reactive protein (CRP), interleukin-6 (IL-6) and fibrinoge...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ijcard.2013.06.028

    authors: Harhay MO,Tracy RP,Bagiella E,Barr RG,Pinder D,Hundley WG,Bluemke DA,Kronmal RA,Lima JA,Kawut SM

    更新日期:2013-10-09 00:00:00

  • Overriding atrioventricular valves. An angiographic-anatomical correlate.

    abstract::An analysis of 6 patients with overriding atrioventricular valve was performed in order to correlate the anatomic and angiographic features of this malformation. The atrial arrangement was usual (situs solitus) in each patient. The ventricular chambers were normally related in 4 and the mirror image of normal in 2. Th...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/0167-5273(85)90031-2

    authors: Soto B,Ceballos R,Nath PH,Bini RM,Pacifico AD,Bargeron LM Jr

    更新日期:1985-11-01 00:00:00

  • Which factors determine the long-term outcome among patients with a very small or unconfirmed AMI.

    abstract:AIM:To describe various factors associated with the very long-term prognosis for patients with a very small or an unconfirmed acute myocardial infarction (AMI). METHODS:Patients below 76 years of age, hospitalized due to suspected AMI who either developed a very small AMI (enzyme elevation

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/s0167-5273(01)00383-7

    authors: Karlson BW,Lindqvist J,Sjölin M,Caidahl K,Herlitz J

    更新日期:2001-05-01 00:00:00

  • Angiographic evidence of progressive lumen narrowing over 2 years following drug-eluting stent implantation.

    abstract:BACKGROUND:Questions persist regarding the ability of drug-eluting stents (DES) to inhibit intimal growth in the long-term. METHODS:We prospectively enrolled 766 lesions treated with DES that underwent angiographic examination at 6 months and 2 years after stenting. Lesions with 6-month restenosis (>50% of visual sten...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ijcard.2010.08.032

    authors: Park SJ,Kim YH,Kim WJ,Ahn JM,Yun SC,Lee JY,Park DW,Kang SJ,Lee SW,Lee CW,Park SW

    更新日期:2011-12-01 00:00:00

  • The role of angioplasty in patients with acute coronary syndrome and previous coronary artery bypass grafting.

    abstract:INTRODUCTION:Angioplasty has changed the management of acute coronary syndrome (ACS). However, in patients with previous coronary artery bypass grafting (CABG), the role of angioplasty in the management of ACS is widely debated. Lack of clear guidelines leads to subjective and often stereotypical assessments based on c...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2014.07.097

    authors: Potluri R,Baig M,Mavi JS,Ali N,Aziz A,Uppal H,Chandran S

    更新日期:2014-10-20 00:00:00

  • Sudden cardiac arrest in a teenager as first manifestation of Takayasu's disease.

    abstract::A 14-year-old girl was rescued from a sudden cardiac arrest at school. Aortography disclosed mild aortic root dilation with aortic valve incompetence and subocclusion of coronary ostia and left common carotid artery. An emergency aortocoronary bypass operation was undertaken, but the patient did not recover from cardi...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/0167-5273(94)90095-7

    authors: Basso C,Baracca E,Zonzin P,Thiene G

    更新日期:1994-01-01 00:00:00

  • Association between time of out-of-hospital cardiac arrest and survival: Examination of the all-Japan Utstein registry and comparison with the 2005 and 2010 international resuscitation guidelines.

    abstract:BACKGROUND:Existing studies have yielded conflicting results regarding the relationship between the time of occurrence of out-of-hospital cardiac arrests and the associated outcomes. We examined whether the one-month survival rate for out-of-hospital cardiac arrests differed depending on whether the cardiac arrest occu...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2020.09.043

    authors: Kato K,Otsuka T,Seino Y,Tahara Y,Yonemoto N,Nonogi H,Nagao K,Ikeda T,Sato N,Tsutsui H,Japanese Circulation Society with Resuscitation Science Study (JCS-ReSS) Group.

    更新日期:2021-02-01 00:00:00

  • Non-invasive assessment of coronary artery disease in patients with left bundle branch block.

    abstract::There is a high prevalence of coronary artery disease (CAD) in patients with left bundle branch block (LBBB); however there are many other causes for this electrocardiographic abnormality. Non-invasive assessment of these patients remains difficult, and all commonly used modalities exhibit several drawbacks. This ofte...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijcard.2015.01.084

    authors: Mordi I,Tzemos N

    更新日期:2015-04-01 00:00:00

  • 24 h and prolonged ambulatory ECG recording in patients with ventricular ectopy: Maybe 24 h are not enough?

    abstract:AIM:To assess whether 24-h ambulatory ECG (AECG) recording underestimates arrhythmic risk in subjects with both ventricular ectopy and cardiovascular risk factors or history of coronary heart disease (CHD). METHODS:29 consecutive patients with both ECG evidence of premature ventricular contractions (PVCs) and cardiova...

    journal_title:International journal of cardiology

    pub_type: 信件

    doi:10.1016/j.ijcard.2007.02.055

    authors: Brunetti ND,D'Arienzo G,Tiscia G,Pellegrino PL,De Gennaro L,Di Biase M

    更新日期:2008-07-04 00:00:00

  • Gender differences in evidence-based pharmacological therapy for patients with stable coronary heart disease.

    abstract:BACKGROUND:Women have a higher morbidity and mortality than men after an acute coronary event. We analyzed the prescription rates of evidence-based pharmacological therapies for patients with stable coronary heart disease and whether there were any differences with respect to gender. DESIGN:This cross-sectional study ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2007.12.115

    authors: Lahoz C,Mantilla T,Taboada M,Soler B,Tranche S,López-Rodriguez I,Monteiro B,Martin-Jadraque R,Sanchez-Zamorano MA,Mostaza JM

    更新日期:2009-04-17 00:00:00

  • Experience with moricizine HCl in children with supraventricular tachycardia.

    abstract::Eight children, age between 4.5 and 19 years were treated with moricizine for supraventricular tachycardia during the last 3 years. The tachycardia was documented by surface electrocardiogram (ECG), and/or by ambulatory ECG in all the children and the mechanism of tachycardia was determined by previously published sur...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/s0167-5273(96)02763-5

    authors: Mehta AV,Subrahmanyam AB,Long JB,Kanter RJ

    更新日期:1996-11-15 00:00:00

  • The low expression of circulating microRNA-19a represents an additional mortality risk in stable patients with vascular disease.

    abstract:BACKGROUND:Secondary prevention of atherosclerotic vascular diseases represents a cascade of procedures to reduce the risk of future fatal and non-fatal cardiovascular events. We sought to determine whether the expression of selected microRNAs influenced mortality of stable chronic cardiovascular patients. METHODS:The...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ijcard.2019.05.008

    authors: Mayer O Jr,Seidlerová J,Černá V,Kučerová A,Vaněk J,Karnosová P,Bruthans J,Wohlfahrt P,Cífková R,Pešta M,Filipovský J

    更新日期:2019-08-15 00:00:00

  • ACE inhibitors and unilateral renal artery stenosis--what price?

    abstract::The effects of ACE inhibitors on the stenosed kidney in patients with unilateral arterial stenosis are not well characterised. While there are conflicting reports, some experimental and clinical evidence suggest that the stenosed kidney may undergo atrophy: secondary to effective blood pressure lowering and decreased ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/0167-5273(95)02541-3

    authors: Kothari SS

    更新日期:1996-03-01 00:00:00

  • Atherosclerotic calcification and intimal medial thickness of the carotid arteries.

    abstract:BACKGROUND AND PURPOSE:Carotid intimal medial thickness (IMT) is a measure of subclinical atherosclerosis and is predictive of future cardiovascular events. The purpose of this study was to determine the significance and magnitude of association between IMT and atherosclerotic calcification of the carotid arteries. ME...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2004.12.039

    authors: Allison MA,Tiefenbrun J,Langer RD,Wright CM

    更新日期:2005-08-03 00:00:00

  • Takayasu arteritis evaluated by multi-slice computed tomography in an old man.

    abstract::In the case of patients with Takayasu arteritis (TA), they consult a doctor for the first time when they have a slight fever, shoulder pain, chest pain, back pain, or headache, or when they are pointed out to have high CRP or anemia by chance in medical check-up. In TA, they are usually young women. In our case, the v...

    journal_title:International journal of cardiology

    pub_type: 信件

    doi:10.1016/j.ijcard.2007.05.041

    authors: Fujita T,Ohtsuka M,Uchida E,Yamaguchi H,Nakajima T,Akazawa H,Takano H,Nakaya H,Komuro I

    更新日期:2008-04-10 00:00:00

  • Expression of Lmna-R225X nonsense mutation results in dilated cardiomyopathy and conduction disorders (DCM-CD) in mice: Impact of exercise training.

    abstract:AIMS:To recapitulate progressive human dilated cardiomyopathy (DCM) and heart block in the Lmna R225X mutant mice model and investigate the molecular basis of LMNA mutation induced cardiac conduction disorders (CD); To investigate the potential interventional impact of exercise endurance. METHODS AND RESULTS:A Lmna R2...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2019.09.058

    authors: Cai ZJ,Lee YK,Lau YM,Ho JC,Lai WH,Wong NL,Huang D,Hai JJ,Ng KM,Tse HF,Siu CW

    更新日期:2020-01-01 00:00:00

  • Ultrafiltration for acute decompensated heart failure: a systematic review and meta-analysis of randomized controlled trials.

    abstract:BACKGROUND:Current clinical guidelines recommend ultrafiltration (UF) for patients with acute decompensated heart failure (ADHF) who are unresponsive or resistant to diuretics. We systematically reviewed the latest randomized evidence on the efficacy and safety of UF in ADHF. METHODS:MEDLINE, EMBASE and the Cochrane d...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.ijcard.2014.01.069

    authors: Kwong JS,Yu CM

    更新日期:2014-03-15 00:00:00

  • Effect of age on atrial contribution to ventricular filling after balloon mitral valvuloplasty in mitral stenosis.

    abstract:OBJECTIVE:Ventricular filling takes place during the conduit and pump functions of the atrium. While studying whether relief of mitral valve obstruction improves atrial filling, the effect of age on atrial contribution to ventricular filling was studied before and after balloon mitral valvuloplasty (BMV) and on follow-...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2003.07.015

    authors: Krishnamoorthy KM,Dash PK

    更新日期:2004-08-01 00:00:00

  • Gender and age-dependent differences in the bradykinin-degradation within the pericardial fluid of patients with coronary artery disease.

    abstract::Cardiovascular diseases (CVD) and, in particular, coronary artery disease (CAD) are the leading causes of death in developed countries, especially in the elderly population. Males exhibit a higher risk for cardiovascular events than women. The pericardial fluid (PF) is in direct contact with the epicardial sections of...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2009.06.028

    authors: Bechtloff R,Goette A,Bukowska A,Kähne T,Peters B,Huth C,Wolke C,Lendeckel U

    更新日期:2011-01-21 00:00:00

  • Aquatic exercise training and stable heart failure: A systematic review and meta-analysis.

    abstract:AIM:A meta-analysis and review of the evidence was conducted to determine the efficacy of aquatic exercise training for individuals with heart failure compared to traditional land-based programmes. METHODS:A systematic search was conducted for studies published prior to March 2014, using MEDLINE, PUBMED, Cochrane Libr...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.ijcard.2015.03.095

    authors: Adsett JA,Mudge AM,Morris N,Kuys S,Paratz JD

    更新日期:2015-01-01 00:00:00

  • The pre-existence of an acute coronary event predicts differences in biological parameters and clinical evolution among patients with longstanding stable angina.

    abstract:BACKGROUND:To date, patients displaying stable angina with or without a previous acute coronary event have been grouped together and are offered nowadays, similar clinical approach. However, from clinical experience, increasing doubt exists whether they behave clinically in the same way. In the current study, we invest...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/s0167-5273(03)00028-7

    authors: Sposito AC,Lemos PA,Maranhão RC,Mansur AP,Cesar LA,Ramires JA

    更新日期:2003-10-01 00:00:00