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Acute pulmonary embolism in COVID-19 disease: Preliminary report on seven patients.

Abstract：

:There is some evidence that Covid 19 pneumonia is associated with prothrombotic status and increased risk of venous thromboembolic events (deep venous thrombosis and pulmonary embolism). Over a two-week period we admitted in our Unit 25 patients with Covid-19 pneumonia, of these pulmonary embolism was diagnosed using computed tomography angiography in 7. We report on clinical and biochemical features of these patients. They were all males, with a mean age of 70.3 years (range 58-84); traditional risk factors for venous thromboembolism were identified in the majority of patients with pulmonary embolism, however not differently from those without pulmonary embolism. Clinical presentation of pulmonary embolism patients was usually characterized by persistence or worsening of respiratory symptoms, with increasing oxygen requirement. D-dimer levels were several fold higher than the upper threshold of normal; in patients in whom PE was recognized during hospital stay, a rapid and relevant increase of D-dimer levels was observed. Computed tomographic findings ranged from massive acute pulmonary embolism to a segmental or sub-segmental pattern; furthermore, thrombosis of sub-segmental pulmonary arteries within lung infiltrates were occasionally seen, suggesting local mechanisms. Six out of 7 patients were treated with unfractionated or low molecular weight heparin with clinical benefit within few days; one patient needed systemic thrombolysis (death from hemorrhagic complication).

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Faggiano P,Bonelli A,Paris S,Milesi G,Bisegna S,Bernardi N,Curnis A,Agricola E,Maroldi R

doi

10.1016/j.ijcard.2020.04.028

subject

Has Abstract

pub_date

2020-08-15 00:00:00

pages

129-131

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(20)31901-X

journal_volume

313

pub_type

杂志文章

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