Abstract:
BACKGROUND:Red blood cell and platelet microparticles (RBCm and PLTm, respectively) have drawn research attention as to their potential prothrombotic and vasoconstrictive effects in experimental settings. However, the relevance of circulating microparticles in clinical settings is largely undetermined. METHODS:Circulating microparticles were quantified with a flow cytometric method in blood samples from consecutive STEMI patients after primary PCI. A matched cohort of healthy volunteers was used to derive reference values for comparison. STEMI patients were followed for 6 months for a composite clinical endpoint. RESULTS:Fifty-one STEMI patients (age 59.8 ± 8.8 years) and 50 controls (age 56.2 ± 9.2 years; p=0.155) were enrolled. RBCm concentration was 18,198 ± 6062/μl in the reference cohort versus 33,740 ± 21,169/μl in STEMI patients (p<0.001). RBCm count was not correlated to total RBCs (standardized beta 0.018; p=0.861). PLTm did not differ between groups (17,529 ± 16,292/μl in STEMI patients versus 14,372 ± 6211/μl in controls; p=0.203). RBCm c-statistic was 0.832 (95% confidence interval 0.720 to 0.944), while PLTm prognostic value was not statistically significant (c-statistic 0.614, 95% confidence interval 0.444 to 0.784). In the multivariate analysis, RBCm concentration was independently associated with the occurrence of the clinical endpoint, after adjustment for age, ejection fraction, serum creatinine and presence of diabetes (adjusted p=0.034). CONCLUSIONS:The present study demonstrates for the first time that erythrocyte microparticles are elevated in patients with STEMI treated with primary PCI, with levels approximately double those measured in a reference population of healthy volunteers, and their concentrations appear to be positively associated with adverse clinical events.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Giannopoulos G,Oudatzis G,Paterakis G,Synetos A,Tampaki E,Bouras G,Hahalis G,Alexopoulos D,Tousoulis D,Cleman MW,Stefanadis C,Deftereos Sdoi
10.1016/j.ijcard.2014.07.022subject
Has Abstractpub_date
2014-09-01 00:00:00pages
145-50issue
1eissn
0167-5273issn
1874-1754pii
S0167-5273(14)01214-5journal_volume
176pub_type
杂志文章abstract:BACKGROUND:Current clinical guidelines recommend ultrafiltration (UF) for patients with acute decompensated heart failure (ADHF) who are unresponsive or resistant to diuretics. We systematically reviewed the latest randomized evidence on the efficacy and safety of UF in ADHF. METHODS:MEDLINE, EMBASE and the Cochrane d...
journal_title:International journal of cardiology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.ijcard.2014.01.069
更新日期:2014-03-15 00:00:00
abstract:BACKGROUND:Aortic stenosis (AS) is an active disease, but the determinants of AS progression remain largely unknown. Low levels of Fetuin-A, a powerful inhibitor of ectopic calcification, have been linked to ectopic calcium tissue deposition but its role in AS progression has not been clearly evaluated. METHODS:In our...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.03.070
更新日期:2018-08-15 00:00:00
abstract::We describe a rare case of a sporadiac form of multiple myxoma and highlight the unusual combination of left atrial and right ventricular tumors. Transoesophageal echocardiography proved superior to precordial imaging in detecting all four masses (two in left atrium and two in right ventricle). ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(93)90063-m
更新日期:1993-12-31 00:00:00
abstract:BACKGROUND:Stem cells have a low expansion rate and are difficult to maintain in vitro. To overcome the problems of cardiovascular regeneration, we developed a novel method of stem cell cultivation in culture vessels with amine and carboxyl coatings. METHODS AND RESULTS:We isolated cardiac stem/progenitor cells from i...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2012.09.065
更新日期:2013-09-20 00:00:00
abstract:BACKGROUND AND OBJECTIVES:ATP-binding cassette transporter 1 (ABCA1) is a trans-membrane protein responsible for the efflux of cholesterol and phospholipids across the cell membrane, an essential step in the reverse cholesterol transport system. This study investigates the effect of five non-synonymous SNPs of ABCA1 ge...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2005.12.020
更新日期:2007-01-31 00:00:00
abstract::A case of congenitally divided left atrium detected on cross-sectional echocardiography is described. Simultaneous Doppler examination helped to diagnose the obstructive nature of the partition within the left atrium by locating a turbulent high velocity (2.2 meters/second) diastolic signal. The diagnosis was confirme...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(88)90221-5
更新日期:1988-11-01 00:00:00
abstract::We observed a patient with ventricular septal rupture occurring 33 days after a blunt chest trauma. The presumed mechanism was interventricular septal dissection and formation of a pseudoaneurysm that ruptured after a delay. Echocardiography enabled a non-invasive diagnosis and follow-up of the patient. ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(94)90189-9
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND:An involvement of neutrophil extracellular traps (NETs) in the aortic stenosis (AS) pathogenesis is unknown. METHODS:We enrolled 50 patients, median age 66.5 years with isolated severe AS, after aortic valve replacement and 20 healthy sex/age-matched controls. Autopsy-derived aortic valves from 5 healthy do...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2019.03.047
更新日期:2019-07-01 00:00:00
abstract::We report a patient with a significant residual left-to-right shunt who underwent surgical repair for traumatic VSD. This 13-year-old boy was stabbed with a pair of scissors through his heart. After initial life-saving surgery with lacerated left ventricular wall repair and VSD closure, residual VSD was noted. Six mon...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2006.11.184
更新日期:2008-02-29 00:00:00
abstract::Long-QT syndrome is a clinically and genetically heterogeneous syndrome characterized by lengthening of the QT interval and increased dispersion of the ventricular repolarization on surface electrocardiogram and a propensity to malignant ventricular arrhythmias, torsade de pointes and ventricular fibrillation, which m...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2003.04.018
更新日期:2004-05-01 00:00:00
abstract::As a result of advances in pediatric care, the majority of patients born with congenital heart disease (CHD) survive into adulthood [1]. Effective transfer and transition programs assure that patients with CHD remain in follow-up and receive continuous holistic care. Unfortunately, adult patients with CHD carry residu...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2018.10.078
更新日期:2019-03-15 00:00:00
abstract:BACKGROUND:In-stent stenosis is characterized by a prolonged proliferation and inflammatory reactions around the stent struts. Potentially the antiproliferative and lipid-lowering effects of atorvastatin can synergistically limit neointima formation after stenting. METHODS:Palmaz-Schatz stents were placed in the iliac...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(02)00588-0
更新日期:2003-09-01 00:00:00
abstract::Swyer-James (MacLeod's) syndrome is a rare entity that is characterized by the hyperlucent appearance of one or more lobes of one lung, diminished ipsilateral hilar shadow and hardly visible arterial structure on chest radiography. Ventricular septal defect is the most common childhood congenital heart defect and, if ...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2006.04.042
更新日期:2006-10-26 00:00:00
abstract::There is concern about adverse effects on renal function in patients with prolonged cardiac intervention procedures, when contrast media is used. To investigate this further we studied changes in renal function in 104 patients (79 male, 25 female; mean age 59.2, SD 9.8) undergoing routine elective percutaneous translu...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(99)00063-7
更新日期:1999-07-31 00:00:00
abstract:BACKGROUND:Previous studies have shown that air pollution particulate matter (PM) is associated with an increased risk for myocardial infarction. The effects of air pollution on the risk of ST-elevation myocardial infarction (STEMI), in particular the role of gaseous air pollutants such as NO2 and O3 and the susceptibi...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2016.07.191
更新日期:2016-11-15 00:00:00
abstract:BACKGROUND:Limb electrodes for the 12 lead ECG are routinely placed on the torso during exercise stress testing or when limbs are clinically inaccessible. It is unclear whether such electrode modification produces ECG changes in healthy male or female subjects that are clinically important according to the 2009 AHA, AC...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2010.07.013
更新日期:2011-10-20 00:00:00
abstract:BACKGROUND:Many patients fail to receive β-blockers before cardiac resynchronization therapy defibrillator (CRT-D) implantation, or receive them at a suboptimal dose, and require optimization after implantation. We assessed the effectiveness of a structured program for β-blocker titration in CRT-D patients followed up ...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2017.02.015
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Patients with Fabry disease (FD) develop progressive left ventricular hypertrophy (LVH). In screening studies in patients with LVH, the prevalence of FD ranges from 0 to 12%. This variability is attributable to different factors like diverging inclusion and exclusion criteria, the evaluation of selected popu...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.ijcard.2012.06.069
更新日期:2013-09-10 00:00:00
abstract::We report a case of extensive exfoliative dermatitis in a patient appearing 3 days after intracoronary administration of non-ionic contrast medium Iodixanol (Visipaque) during the primary percutaneous coronary intervention. The patient presented with acute myocardial infarction and has never exposed to any X-ray contr...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2006.11.179
更新日期:2008-02-29 00:00:00
abstract::Microvolt T-wave alternans (TWA) testing involves measuring variation in the morphology of the T-wave on an every other beat basis. The magnitude of the variation observed is typically on the order of a few microvolts. Thus in order to detect microvolt TWA, specialized recording and signal processing methods must be e...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2005.06.049
更新日期:2006-05-24 00:00:00
abstract::A 50-year-old woman who developed severe angina pectoris 67 months following radiation therapy of the left side of the chest for adenocarcinoma of the left breast is reported. Angiographic studies showed an isolated severe stenosis in the left anterior descending coronary artery. Successful percutaneous transluminal c...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(88)90323-3
更新日期:1988-07-01 00:00:00
abstract::A 44-year-old woman with hypertension was admitted because of recent onset chest pain. Coronary angiography revealed an anomalous right coronary artery originating as a separate branch from the left anterior descending artery. Associated with the present case all published case reports were thoroughly investigated and...
journal_title:International journal of cardiology
pub_type: 信件,评审
doi:10.1016/j.ijcard.2007.04.121
更新日期:2008-07-04 00:00:00
abstract:BACKGROUND:In the SURVIVE trial, including 1327 acute heart failure patients, no statistically significant difference between levosimendan and dobutamine in the 180-day all-cause mortality was seen. Country-specific differences in outcome were, however, present. In the Finnish sub-population in fact, mortality was sign...
journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijcard.2016.04.064
更新日期:2016-07-15 00:00:00
abstract::Left ventricular non-compaction (LVNC) is a rare disorder that results in multiple deep trabeculations within the left ventricular myocardium. It is thought to be due in part, to an arrest of myocardial development but more recent evidence suggests that some cases may actually be acquired while other isolated cases ha...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2009.07.003
更新日期:2010-04-15 00:00:00
abstract:BACKGROUND:Ischemic coronary artery disease (CAD) is a major cause for morbidity and mortality resulting in a continuously increasing number of diagnostic interventions. We have validated a new hybrid imaging method using minimized radiation dose for rapid non-invasive prediction of invasive coronary angiography (CA) f...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2010.08.023
更新日期:2011-11-17 00:00:00
abstract::A novel cardiac syndrome of left ventricular apical ballooning (Takotsubo cardiomyopathy-ampulla cardiomyopathy) involves reversible left ventricular apical ballooning (during systole) of acute onset with chest pain, electrocardiographic changes, and minimal elevation of cardiac enzymes resembling acute myocardial inf...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2004.05.070
更新日期:2005-07-10 00:00:00
abstract:BACKGROUND:Noninvasive assessment of coronary plaque is important for coronary risk stratification. Whereas integrated backscatter intravascular ultrasound (IB-IVUS) has proven effective for analysis of the tissue components of coronary plaque, plaque assessment by 64-slice multidetector computed tomography (MDCT) has ...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ijcard.2010.04.002
更新日期:2011-05-19 00:00:00
abstract::Cerebral haemorrhage in anticoagulated patients with mechanical valvular prosthesis poses an uncommon but difficult management problem. Four such patients are presented: one patient had delayed haemorrhagic transformation of a preexisting cerebral infarct, one probably had de novo haemorrhage complicating hypertension...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(91)90005-a
更新日期:1991-03-01 00:00:00
abstract::The exercise electrocardiogram is a commonly used non-invasive method for detection of electrocardiogram (ECG) changes secondary to myocardial ischemia. Studies showed the importance of the patient's motivation to reach the estimated submaximal heart rate. The purpose of this study was to test whether the patient's mo...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2008.04.074
更新日期:2009-08-21 00:00:00
abstract:BACKGROUND:Right ventricular (RV) failure due to increased pressure load causes significant morbidity and mortality in patients with congenital heart diseases and pulmonary arterial hypertension. It is unknown whether renin-angiotensin-aldosterone-system (RAAS) inhibition (the cornerstone of left ventricular failure tr...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2013.08.102
更新日期:2013-11-05 00:00:00