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Sex and age differences and outcomes in acute coronary syndromes.

Abstract：

BACKGROUND:There is conflicting information about sex differences in presentation, treatment, and outcome after acute coronary syndromes (ACS) in the era of reperfusion therapy and percutaneous coronary intervention. The aim of this study was to examine presentation, acute therapy, and outcomes of men and women with ACS with special emphasis on their relationship with younger age (≤65years). METHODS:From January 2010 to June 2015, we enrolled 5140 patients from 3 primary PCI capable hospitals. Patients were registered according to the International Survey of Acute Coronary Syndrome in Transitional Countries (ISACS-TC) registry protocol (ClinicalTrials.gov: NCT01218776). The primary outcome was the incidence of in-hospital mortality. RESULTS:The study population was constituted by 2876 patients younger than 65years and 2294 patients older. Women were older than men in both the young (56.2±6.6 vs. 54.1±7.4) and old (74.9±6.4 vs. 73.6±6.0) age groups. There were 3421 (66.2%) patients with ST elevation ACS (STE-ACS) and 1719 (33.8%) patients without ST elevation ACS (NSTE-ACS). In STE-ACS, the percentage of patients who failed to receive reperfusion was higher in women than in men either in the young (21.7% vs. 15.8%) than in the elderly (35.2% vs. 29.6%). There was a significant higher mortality in women in the younger age group (age-adjusted OR 1.52, 95% CI: 1.01-2.29), but there was no sex difference in the older group (age-adjusted OR 1.10, 95% CI: 0.87-1.41). Significantly sex differences in mortality were not seen in NSTE-ACS patients. CONCLUSIONS:In-hospital mortality from ACS is not different between older men and women. A higher short-term mortality can be seen only in women with STEMI and age of 65 or less.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Vasiljevic-Pokrajcic Z,Mickovski N,Davidovic G,Asanin M,Stefanovic B,Krljanac G,Radosavljevic-Radovanovic M,Radovanovic N,Lasica R,Milanović S,Bjekić J,Majstorovic-Stakic M,Trifunovic D,Karadzic A,Rajic D,Milosevic A,Zdra

doi

10.1016/j.ijcard.2016.06.217

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

S27-31

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(16)31231-1

journal_volume

217 Suppl

pub_type

临床试验,杂志文章

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Sex and age differences and outcomes in acute coronary syndromes.