当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF CARDIOLOGY期刊下所有文献 > Office blood pressure is a predictor of aortic elastic properties and urinary protein excretion in subjects with white coat hypertension.

Office blood pressure is a predictor of aortic elastic properties and urinary protein excretion in subjects with white coat hypertension.

Abstract：

BACKGROUND:White coat hypertension (WCH) is related to target organ damage and increased cardiovascular risk. Arterial elastic properties and urinary protein excretion are determinants of cardiovascular performance and predictors of outcomes. We investigated whether office blood pressure (BP) is a better determinant of arterial and renal function than the ambulatory BP in WCH patients. METHODS:We studied 440 consecutive untreated non-diabetic patients with WCH (office BP >140/90 mmHg, mean daytime ambulatory BP <135/85 mmHg). Arterial function was evaluated with carotid-femoral pulse wave velocity (cfPWV), an index of aortic stiffness, and aortic augmentation index (AIx), a composite marker of aortic stiffness and wave reflections. In 24-hour urine, albumin excretion and albumin/creatinine ratio (ACR) were measured as markers of glomerular function and urinary α1-microglobulin was measured as a marker of renal tubular function. RESULTS:In univariate analysis, office systolic BP correlated significantly with cfPWV (r=0.245, P<0.001), AIx (r=0.31, P<0.001), albumin (r=0.134, P=0.005), ACR (r=0.199, P<0.001) and α1-microglobulin (r=0.118, P=0.013). In contrast, mean ambulatory systolic BP did not correlate with arterial function or urinary proteins (all P>0.5). Hierarchical multilevel linear regression analysis showed that office systolic BP is an independent determinant of cfPWV (P=0.050), AIx (P=0.029), albumin (P=0.002) and ACR (P=0.001) and has a borderline association with α1-microglobulin (P=0.088). CONCLUSIONS:In non-diabetic WCH individuals, office systolic BP is an independent predictor of aortic elastic properties and urinary protein excretion, whereas ambulatory BP is not. This finding suggests that office BP may be a marker of cardiovascular risk in subjects with WCH.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Aznaouridis K,Vlachopoulos C,Masoura K,Pietri P,Vyssoulis G,Ioakeimidis N,Stefanadis C,Tousoulis D

doi

10.1016/j.ijcard.2015.10.078

subject

Has Abstract

pub_date

2016-01-15 00:00:00

pages

98-103

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(15)30644-6

journal_volume

203

pub_type

杂志文章

在线工具

Office blood pressure is a predictor of aortic elastic properties and urinary protein excretion in subjects with white coat hypertension.