当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF CARDIOLOGY期刊下所有文献 > Non-red blood cell transfusion as a risk factor for mortality following percutaneous coronary intervention.

Non-red blood cell transfusion as a risk factor for mortality following percutaneous coronary intervention.

Abstract：

BACKGROUND:Bleeding following percutaneous coronary intervention (PCI) is common and may lead to transfusion and death. Although previous work has examined the effect of red blood cell (RBC) transfusion in patients with coronary disease, no study had investigated whether transfusion of non-RBC components was associated with mortality following PCI. METHODS:All subjects transfused in the 10 days following PCI were identified using the British Columbia Cardiac and Central Transfusion Registries. Patients undergoing cardiac surgery following PCI were excluded as transfusion was assumed to be due to surgical related bleeding. Transfusion products were categorised as RBC and non-RBC comprising platelets, plasma and cryoprecipitate. Blood product use was compared according to thirty day mortality using multivariate regression and propensity adjustment for confounding variables. RESULTS:From a total of 32,580 patients who underwent PCI, 952 patients received at least 1 blood product within 10 days of PCI. Non-RBC transfusion occurred more commonly in the cohort of transfused patients dying within 30 days (p<0.001). After adjustment for baseline risk, transfusion of plasma/cryoprecipitate (HR 5.17; 95% C.I. 2.87-9.32, p<0.001) and platelets (HR 2.13; 95% C.I. 1.10-4.13, p=0.03) was associated with increased 30 day mortality. In a propensity risk adjusted model, transfusion of plasma/cryoprecipitate and RBC transfusion volume remained as significant predictors of 30-day mortality (p<0.001). CONCLUSIONS:Transfusion following PCI appears to be associated with an increased risk of death within 30 days. We now report that transfusion with plasma rich non-RBC products may confer an additional mortality risk to patients undergoing PCI.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Robinson SD,Janssen C,Fretz EB,Chase AJ,Siega AD,Carere RG,Fung A,Simkus G,Hilton JD,Berry B,Klinke WP

doi

10.1016/j.ijcard.2010.12.013

subject

Has Abstract

pub_date

2012-05-31 00:00:00

pages

169-73

issue

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(10)01054-5

journal_volume

157

pub_type

杂志文章

在线工具

Non-red blood cell transfusion as a risk factor for mortality following percutaneous coronary intervention.