当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF CARDIOLOGY期刊下所有文献 > Circadian heart rate and blood pressure variability considered for research and patient care.

Circadian heart rate and blood pressure variability considered for research and patient care.

Abstract：

OBJECTIVES:To review mechanisms of circadian variations in heart rate variability (HRV) and blood pressure variability (BPV) and mortality and morbidity due to cardiovascular diseases (CVD). METHODS:Results from 7-day/24-h HRV and BPV are interpreted by gender and age-specified reference values in the context of a Medline search. RESULTS:Abnormal HRV and BPV measured around the clock for 7 days provides information on the risk of subsequent morbid events in subjects without obvious heart disease and without abnormality outside the conventional (in the sense of chronobiologically unquantified) physiological range. Meditation, beta-blockers, ACE inhibitors, n-3 fatty acids and estrogens may have a beneficial influence on HRV, but there is no definitive outcome-validated therapy. Low HRV has been associated with a risk of arrhythmias and arrhythmic death, unstable angina, myocardial infarction, progression of heart failure and atherosclerosis. BPV may be characterized by treatable circadian-hyper-amplitude-tension (CHAT), which can be transient '24-h CHAT' or '7-day-CHAT', MESOR-hypertension and/or an unusually-timed (odd) circadian acrophase (ecphasia), all associated with an increased risk of stroke, stroke death, myocardial infarction, and kidney disease. CONCLUSIONS:Precise insight into the patho-physiology in time of HRV and BPV is needed with development of a consensus on best measures of HRV for clinical purposes and to determine when a 7-day record interpreted chronobiologically suffices and when it does not, for detection within as well as outside the conventional normal range, for diagnostic clinical practice and to direct therapy of risk greater than that associated with hypertension, smoking or any other risk factor.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Singh RB,Cornélissen G,Weydahl A,Schwartzkopff O,Katinas G,Otsuka K,Watanabe Y,Yano S,Mori H,Ichimaru Y,Mitsutake G,Pella D,Fanghong L,Zhao Z,Rao RS,Gvozdjakova A,Halberg F

doi

10.1016/s0167-5273(02)00308-x

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

9-28; discussion 29-30

issue

eissn

0167-5273

issn

1874-1754

pii

S016752730200308X

journal_volume

pub_type

杂志文章,评审

在线工具

Circadian heart rate and blood pressure variability considered for research and patient care.