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Left ventricular diastolic function in hypertension: a 4 year follow-up study.

Abstract：

:In order to assess the long term effects of antihypertensive treatment on left ventricular diastolic function, 26 hypertensive patients were followed up for a mean of 4.25 years with two-dimensional and Doppler echocardiography. A significant reduction in left ventricular mass index was first apparent after 9 months of therapy (mean (S.D.) 124 (22) vs. 114 (18) g/m2, P < 0.01), and this was maintained over the 4.25 year period (124 (22) vs. 117 (17) g/m2, p < 0.05). At 9 months there was no change in either isovolumic relaxation time (108 (26) vs. 108 (17) ms, P = N.S.) or left ventricular filling as assessed by peak flow velocity E/A ratio (0.94 (0.22) vs. 0.95 (0.27), P = N.S.). However, after 4.25 years there was a significant improvement in IVRT (108 (26) vs. 83 (11) ms, P < 0.01) with a trend towards an improved peak flow velocity E/A ratio, although this did not reach statistical significance (0.95 (0.27) vs. 1.02 (0.26), P = N.S.). Of the 14 patients who had an abnormal isovolumic relaxation time at baseline, 12 normalised and 2 improved. These findings suggest that left ventricular diastolic dysfunction in hypertension may be reversed by prolonged antihypertensive treatment.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Mayet J,Shahi M,Poulter NR,Sever PS,Foale RA,Thom SA

doi

10.1016/0167-5273(95)02367-6

subject

Has Abstract

pub_date

1995-06-30 00:00:00

pages

181-8

issue

2

eissn

0167-5273

issn

1874-1754

pii

0167527395023676

journal_volume

50

pub_type

杂志文章

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