Abstract:
:The anti-ischemic properties of the new cardioselective beta-adrenoreceptor antagonist celiprolol were investigated in an open study of 12 men (mean age: 58 +/- 6.6 years) with exercise-induced angina pectoris. After all previous anti-anginal medication had been withdrawn for at least 5 half-lives, the patients received placebo, single doses of nitroglycerin buccal spray, sublingual nifedipine, celiprolol alone, and then in association with nitroglycerin and nifedipine. Exercise tests were performed on a bicycle ergometer, with continuous electrocardiographic monitoring. Significantly more work was completed after treatment with celiprolol than at baseline (5280 +/- 2500 versus 4005 +/- 1792 kpm; P less than 0.01). There were further improvements in work completed after the addition of nitroglycerin and nifedipine. Celiprolol reduced the mean resting heart rate from a baseline value of 77.1 beats/min to 69.2 beats/min (P less than 0.01). In contrast, nifedipine induced tachycardia (82.6 beats/min). At rest, all treatments significantly reduced systolic blood pressure, but only nifedipine significantly reduced diastolic blood pressure. At the completion of the exercise protocol, celiprolol reduced the maximal systolic and diastolic blood pressure (P less than 0.05) with further decreases after the addition of nifedipine. The double product was significantly decreased by celiprolol compared with control, nitroglycerin and nifedipine. There was a further improvement of the double product after the addition of nitroglycerin to celiprolol, but the further increase after addition of nifedipine was not significant. In conclusion, it is clear that celiprolol, both alone and in combination with nitroglycerin or nifedipine, can significantly increase the work capacity of patients with exercise-induced angina pectoris and significantly reduce myocardial oxygen consumption.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Douard H,Koch M,Laporte T,Abella ML,Provendier O,Broustet JPdoi
10.1016/0167-5273(89)90163-0subject
Has Abstractpub_date
1989-10-01 00:00:00pages
63-8issue
1eissn
0167-5273issn
1874-1754pii
0167-5273(89)90163-0journal_volume
25pub_type
临床试验,杂志文章abstract:INTRODUCTION:Atrial fibrillation (AF) often converts to and from atrial tachycardia (AT), but it is undefined if these rhythms are mechanistically related in such patients. We tested the hypothesis that critical sites for AT may be related to regional AF sources in patients with both rhythms, by mapping their locations...
journal_title:International journal of cardiology
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(95)02427-x
更新日期:1995-10-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2007.06.020
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journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2010.04.006
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journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
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更新日期:2003-04-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
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journal_title:International journal of cardiology
pub_type: 信件
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journal_title:International journal of cardiology
pub_type: 杂志文章
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pub_type: 信件
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journal_title:International journal of cardiology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,meta分析
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