Abstract:
BACKGROUND:Elevated catecholamines are known to be cardiotoxic, but their potential injurious effects on skeletal muscles are largely unknown. We have investigated whether isoprenaline induces in vivo myocyte necrosis in rat soleus muscle, and characterised the time-course, dose-response, spatial distribution and adrenoceptor involvement of its myotoxicity, in comparison with effects on cardiomyocytes in the same animals. MATERIAL AND METHODS:Myocyte necrosis in response to subcutaneous isoprenaline was detected in vivo using a monoclonal anti-myosin antibody. Secondary immunoperoxidase staining (in vitro) facilitated the localisation of the damage and quantitative image analysis. RESULTS:Using this sensitive technique we report a novel observation that isoprenaline induces significant myocyte necrosis (5-10%) in the soleus muscle. This toxic damage was initiated at lower doses of isoprenaline than in the myocardium (1 vs. 10 microg kg(-1) s.c.), and peaked earlier (at 12 vs. 18 h post injection). Damage was distributed throughout the soleus muscle, whereas cardiomyocyte necrosis was most marked in left ventricular subendocardium where it was approximately 10 and three times greater than in the subepicardium and atria, respectively. Using selective adrenoceptor (AR) antagonism, we found that isoprenaline myotoxicity was mediated via beta(2)-AR in the soleus and via beta(1)-AR in the myocardium. CONCLUSION:The results show that the myopathic effects of isoprenaline are not confined to the heart. The involvement of skeletal muscle with different characteristics and mechanisms may have important implications in elucidating and treating the generalised myopathic processes seen in heart failure patients who have elevated levels of circulating catecholamines.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Ng Y,Goldspink DF,Burniston JG,Clark WA,Colyer J,Tan LBdoi
10.1016/s0167-5273(02)00369-8subject
Has Abstractpub_date
2002-12-01 00:00:00pages
299-309issue
2-3eissn
0167-5273issn
1874-1754pii
S0167527302003698journal_volume
86pub_type
杂志文章abstract:OBJECTIVE:Determining the adherence to ACC/AHA/ESC 2006 guidelines and its influence on the survival of patients with atrial fibrillation. METHODS:Prospective observational study of patients discharged during 2007 from an Internal Medicine department with a main or secondary diagnose of atrial fibrillation. The stroke...
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pub_type: 杂志文章
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更新日期:2014-09-20 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2007-04-25 00:00:00
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更新日期:2008-10-30 00:00:00
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pub_type: 杂志文章
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更新日期:2011-08-04 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
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journal_title:International journal of cardiology
pub_type: 杂志文章,评审
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更新日期:2011-01-21 00:00:00
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更新日期:2016-04-01 00:00:00
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更新日期:1992-04-01 00:00:00
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更新日期:2017-12-15 00:00:00
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更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2020-01-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1996-04-19 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:1986-03-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2017-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2017-02-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2016-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.ijcard.2012.03.115
更新日期:2013-08-20 00:00:00
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更新日期:2019-01-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2015.03.064
更新日期:2015-07-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2017-08-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2012.05.034
更新日期:2013-09-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2016-11-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2006.03.040
更新日期:2007-03-20 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2019.11.127
更新日期:2020-03-01 00:00:00