Abstract:
:The host takes use of pattern recognition receptors (PRRs) to defend against pathogen invasion or cellular damage. Among microorganism-associated molecular patterns detected by host PRRs, nucleic acids derived from bacteria or viruses are tightly supervised, providing a fundamental mechanism of host defense. Pathogenic DNAs are supposed to be detected by DNA sensors that induce the activation of NFκB or TBK1-IRF3 pathway. DNA sensor cGAS is widely expressed in innate immune cells and is a key sensor of invading DNAs in several cell types. cGAS binds to DNA, followed by a conformational change that allows the synthesis of cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) from adenosine triphosphate and guanosine triphosphate. cGAMP is a strong activator of STING that can activate IRF3 and subsequent type I interferon production. Here we describe recent progresses in DNA sensors especially cGAS in the innate immune responses against pathogenic DNAs.
journal_name
Protein Celljournal_title
Protein & cellauthors
Xia P,Wang S,Gao P,Gao G,Fan Zdoi
10.1007/s13238-016-0320-3subject
Has Abstractpub_date
2016-11-01 00:00:00pages
777-791issue
11eissn
1674-800Xissn
1674-8018pii
10.1007/s13238-016-0320-3journal_volume
7pub_type
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